Nicola Marchi
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View article: A Microfluidic Platform for Whole-Membrane Integrity Profiling in Live Neuronal Cells
A Microfluidic Platform for Whole-Membrane Integrity Profiling in Live Neuronal Cells Open
Structural and functional compromise of the cellular membrane are central mechanisms in the pathogenesis of numerous diseases, including neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. However, existing techniques …
View article: Neurophysiological and neuroinflammatory adaptations to seizure activity in aging
Neurophysiological and neuroinflammatory adaptations to seizure activity in aging Open
The pathophysiological impact of late-onset seizures on the brain is not well understood. Here, we investigated whether an initial pattern of generalized seizures (GS) with an electrographically defined ictal-interictal continuum, occurrin…
View article: Integrating cellular and soluble immune signatures of major depression with and without recent suicide attempts
Integrating cellular and soluble immune signatures of major depression with and without recent suicide attempts Open
View article: Bisphenol analogue exposure at low concentrations modifies heart-brain functions and transcriptomics in zebrafish larvae
Bisphenol analogue exposure at low concentrations modifies heart-brain functions and transcriptomics in zebrafish larvae Open
View article: Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations
Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations Open
View article: A Microfluidic Platform for Whole-Membrane Integrity Profiling in Live Neuronal Cells
A Microfluidic Platform for Whole-Membrane Integrity Profiling in Live Neuronal Cells Open
Structural and functional compromise of the cellular membrane are central mechanisms in the pathogenesis of numerous diseases, including neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. However, existing techniques …
View article: Publisher Correction: Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study
Publisher Correction: Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study Open
View article: Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study
Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study Open
Drug-resistant epilepsy (DRE) presents significant challenges in treatment and management. While seizure-related alterations in peripheral immune players are increasingly recognized, the involvement of the immune complement system remains …
View article: Bursts of brain erosion: seizures and age-dependent neurological vulnerability
Bursts of brain erosion: seizures and age-dependent neurological vulnerability Open
View article: Sex-Specific Complement and Cytokine Imbalances in Drug-Resistant Epilepsy: Biomarkers of Immune Vulnerability
Sex-Specific Complement and Cytokine Imbalances in Drug-Resistant Epilepsy: Biomarkers of Immune Vulnerability Open
Objective Drug-resistant epilepsy (DRE) poses significant challenges in treatment and management. While seizure-related alterations in peripheral immune players are increasingly recognized, the involvement of the complement system, central…
View article: Concordance between venous sinus pressure and intracranial pressure in patients investigated for idiopathic intracranial hypertension
Concordance between venous sinus pressure and intracranial pressure in patients investigated for idiopathic intracranial hypertension Open
View article: Prevalence, clinical presentation, and treatment-management of cerebral venous thrombosis associated with spontaneous intracranial hypotension: A combined case-series and systematic literature review approach
Prevalence, clinical presentation, and treatment-management of cerebral venous thrombosis associated with spontaneous intracranial hypotension: A combined case-series and systematic literature review approach Open
Background Cerebral venous thrombosis (CVT) is a rare complication of spontaneous intracranial hypotension (SIH). Therefore, its correct diagnosis and the corresponding optimal treatment-management identification remains challenging. Metho…
View article: Inflammation biomarkers in the intracranial blood are associated with outcome in patients with ischemic stroke
Inflammation biomarkers in the intracranial blood are associated with outcome in patients with ischemic stroke Open
Background Performing endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) allows a port of entry for intracranial biological sampling. Objective To test the hypothesis that specific immune players are molecular contri…
View article: Continuous low-level dietary exposure to glyphosate elicits dose and sex-dependent synaptic and microglial adaptations in the rodent brain.
Continuous low-level dietary exposure to glyphosate elicits dose and sex-dependent synaptic and microglial adaptations in the rodent brain. Open
View article: PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions
PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions Open
View article: Dual-Hit: Glyphosate exposure at NOAEL level negatively impacts birth and glia-behavioural measures in heterozygous shank3 mutants
Dual-Hit: Glyphosate exposure at NOAEL level negatively impacts birth and glia-behavioural measures in heterozygous shank3 mutants Open
View article: CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders
CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders Open
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting 70–90% of obese individuals. In humans, a lower NAFLD incidence is reported in pre-menopausal women, although the mechanisms a…
View article: Lower systemic nitric oxide bioactivity, cerebral hypoperfusion and accelerated cognitive decline in formerly concussed retired rugby union players
Lower systemic nitric oxide bioactivity, cerebral hypoperfusion and accelerated cognitive decline in formerly concussed retired rugby union players Open
Following retirement from sport, the chronic consequences of prior‐recurrent contact are evident and retired rugby union players may be especially prone to accelerated cognitive decline. The present study sought to integrate molecular, cer…
View article: High-speed optical mapping of heart and brain voltage activities in zebrafish larvae exposed to environmental contaminants
High-speed optical mapping of heart and brain voltage activities in zebrafish larvae exposed to environmental contaminants Open
Environmental contaminants represent a poorly understood ecotoxicological and health risk. Here, we advanced a high-speed optical mapping (OM) technique to non-invasively track voltage dynamics in living zebrafish larvae's heart and brain …
View article: Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories
Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories Open
View article: Lifelong exposure to high‐altitude hypoxia in humans is associated with improved redox homeostasis and structural–functional adaptations of the neurovascular unit
Lifelong exposure to high‐altitude hypoxia in humans is associated with improved redox homeostasis and structural–functional adaptations of the neurovascular unit Open
High‐altitude (HA) hypoxia may alter the structural–functional integrity of the neurovascular unit (NVU). Herein, we compared male lowlanders ( n = 9) at sea level (SL) and after 14 days acclimatization to 4300 m (chronic HA) in Cerro de P…
View article: Neurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with heart–brain dysfunctions in adulthood
Neurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with heart–brain dysfunctions in adulthood Open
Aim Retrospective studies suggest that mild traumatic brain injury (mTBI) in pediatric patients may lead to an increased risk of cardiac events. However, the exact functional and temporal dynamics and the associations between heart and bra…
View article: Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B Open
View article: Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury
Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury Open
View article: Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance - the case of S100B
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance - the case of S100B Open
Blood biomarkers of neurological diseases are often employed to rule out or confirm the presence of significant intracranial or cerebrovascular pathology or for the differential diagnosis of conditions with similar presentations (e.g., hem…
View article: Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways Open
Objective Although epilepsies and neurodegenerative disorders show pathophysiological similarities, their direct functional associations are unclear. Here, we tested the hypothesis that experimental seizures can induce tau hyperphosphoryla…
View article: Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging
Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging Open
The term neurovascular unit (NVU) describes the structural and functional liaison between specialized brain endothelium, glial and mural cells, and neurons. Within the NVU, the blood‐brain barrier (BBB) is the microvascular structure regul…
View article: Diagnostic Pharmacokinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance - the case of S100B
Diagnostic Pharmacokinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance - the case of S100B Open
Blood biomarkers of neurological diseases are often employed to rule out or confirm the presence of significant intracranial or cerebrovascular pathology or for the differential diagnosis of conditions with similar presentations (e.g., hem…
View article: Chronic Glucocorticoids Consumption Triggers and Worsens Experimental Alzheimer’s Disease-Like Pathology by Detrimental Immune Modulations
Chronic Glucocorticoids Consumption Triggers and Worsens Experimental Alzheimer’s Disease-Like Pathology by Detrimental Immune Modulations Open
Introduction: Among the risk factors identified in the sporadic forms of Alzheimer’s disease (AD), environmental and lifestyle elements are of growing interest. Clinical observations suggest that stressful events can anticipa…
View article: Experimental status epilepticus, COX‐2 and BDNF: Connecting the dots
Experimental status epilepticus, COX‐2 and BDNF: Connecting the dots Open
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