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View article: A prospective investigation of early-onset colorectal cancer risk factors–pooled analysis of three large-scale European cohorts
A prospective investigation of early-onset colorectal cancer risk factors–pooled analysis of three large-scale European cohorts Open
Adiposity, physical inactivity, smoking, and alcohol consumption are risk factors for EOCRC. Risk factors were largely similar between EOCRC and LOCRC, except for adiposity, with stronger EOCRC association in men.
View article: Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes
Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes Open
Background Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-charact…
View article: Europa Clipper Magnetometer Boom Deployment: A First Look at the Magnetometer Observations of the Spacecraft and the Interplanetary Magnetic Field
Europa Clipper Magnetometer Boom Deployment: A First Look at the Magnetometer Observations of the Spacecraft and the Interplanetary Magnetic Field Open
The online version contains supplementary material available at 10.1007/s11214-025-01238-7.
View article: Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study
Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study Open
Background Physical activity is associated with lower colorectal cancer (CRC) risk, but its association with molecular subtypes defined by genetic and epigenetic alterations of the disease is unclear. Such information may enhance the under…
View article: Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis
Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis Open
Introduction There is convincing evidence that overall adiposity increases the risks of several cancers. Whether the distribution of adiposity plays a similar role is unclear. Methods We used 2-sample Mendelian randomization (MR) to examin…
View article: Genetic risk factors modulate the association between physical activity and colorectal cancer
Genetic risk factors modulate the association between physical activity and colorectal cancer Open
Background Physical activity (PA) is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene–PA interaction an…
View article: Assessing genotype−phenotype correlations in colorectal cancer with deep learning: a multicentre cohort study
Assessing genotype−phenotype correlations in colorectal cancer with deep learning: a multicentre cohort study Open
German Federal Ministry of Health, Max-Eder-Programme of German Cancer Aid, German Federal Ministry of Education and Research, German Academic Exchange Service, and the EU.
View article: TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method
TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method Open
Background Red and/or processed meat are established colorectal cancer (CRC) risk factors. Genome-wide association studies (GWAS) have reported over 200 variants associated with CRC risk. We used functional annotation data to identify subs…
View article: Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes
Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes Open
Genome-wide association studies have suggested numerous colorectal cancer (CRC) susceptibility genes, but their causality and therapeutic potential remain unclear. To prioritise causal associations between gene expression/splicing and CRC …
View article: Supplementary Table 3 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 3 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 3 shows the number of cancer cases and controls in the Mendelian randomization study of genetic liability to allergic diseases and asthma-related phenotypes and risk of colorectal cancer.
View article: Supplementary Table 5 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 5 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 5 shows the Mendelian randomization estimates for the potential causal effect of genetic liability to allergic diseases on white blood cells.
View article: Supplementary Table 4 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 4 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 4 shows the genome-wide significant variants related to (a) allergic diseases (asthma, hay fever, or eczema), (b) early-onset asthma, (c) later-onset asthma, (d) atopic asthma, and (e) hay fever or eczema and their asso…
View article: Supplementary Table 1 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 1 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 1 shows summary-level genetic association data of genetic liability to allergic diseases and colorectal cancer.
View article: Data from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Data from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Background:The tumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer r…
View article: Supplementary Table 2 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 2 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 2 shows the genetic variant overlap (same variants or variants in LD R2>0.001 between exposures) for the three exposures tested in our Mendelian randomization analyses (i.e., genetic liability to allergic diseases and t…
View article: Supplementary Figure 1 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Figure 1 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Figure 1 shows the graphical representation of the hypothesized mediating role of white blood cells in the association between allergic diseases and colorectal cancer risk.
View article: Supplementary Table 7 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 7 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 7 shows the Mendelian randomization estimates for the potential causal effect of genetic liability to allergic diseases and asthma on colorectal cancer risk; leave one genetic variant out sensitivity analyses.
View article: Supplementary Table 6 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 6 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 6 shows the Mendelian randomization estimates for the potential causal effect of white blood cells on colorectal cancer risk.
View article: Table S11 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S11 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between ABSI, colorectal cancer, and its molecular subtypes stratifying by early and later-onset.
View article: Data from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Data from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Background:Waist circumference (WC) and its allometric counterpart, “a body shape index” (ABSI), are risk factors for colorectal cancer; however, it is uncertain whether associations with these body measurements are limited to specific mol…
View article: Table S8 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S8 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between A Body Shape Index (ABSI), distal colon cancer, and its molecular subtypes.
View article: Supplementary figure S1 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary figure S1 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary figure S1: Total variation in the metabolomics data and its sources before and after the normalization procedure Panel A shows the overall variability and its sources before the normalization procedure and panel B shows the o…
View article: Table S7 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S7 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between A Body Shape Index (ABSI), proximal colon cancer, and its molecular subtypes.
View article: Supplementary figure S3 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary figure S3 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary figure S3: The contribution to the metabolic signature of each identified metabolite This graph shows the loadings of the metabolites contributing to the metabolomic signature. Higher bars correspond to larger contribution of…
View article: Table S12 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S12 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between waist circumference, colorectal cancer, and its molecular subtypes after conducting multiple imputation.
View article: Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary table S6: Associations of physical activity with the metabolites analysed in the EPIC study without BMI adjustment.
View article: Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary table S6: Associations of physical activity with the metabolites analysed in the EPIC study without BMI adjustment.
View article: Table S5 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S5 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between waist circumference, distal colon cancer, and its molecular subtypes.