Noriaki Ohuchi
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View article: Supplementary Table 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Supplementary Table 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
Supplementary Table 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
View article: Supplementary Figure 2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Supplementary Figure 2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
Supplementary Figure 2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
View article: Data from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Data from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Studies with tracking of single nanoparticles are providing new insights into the interactions and processes involved in the transport of drug carriers in living mice. Here, we report the tracking of a single particle quantum dot (Qdot) co…
View article: Supplementary Figure Legends 1-3 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Supplementary Figure Legends 1-3 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Supplementary Figure Legends 1-3 from In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
View article: Supplementary Figure 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Supplementary Figure 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
Supplementary Figure 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
View article: Supplementary Figure 2 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Supplementary Figure 2 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Supplementary Figure 2 from In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
View article: Supplementary Figure 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Supplementary Figure 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
Supplementary Figure 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
View article: Supplementary Figure Legends 1-2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Supplementary Figure Legends 1-2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
Supplementary Figure Legends 1-2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
View article: Supplementary Figure Legends 1-3 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Supplementary Figure Legends 1-3 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Supplementary Figure Legends 1-3 from In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
View article: Data from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Data from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
17β-Hydroxysteroid dehydrogenase type 12 (17β-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). 17β-HSD12 expression was also reported in breast carcinoma…
View article: Supplementary Figure 3 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Supplementary Figure 3 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Supplementary Figure 3 from In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
View article: Supplementary Figure Legends 1-2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Supplementary Figure Legends 1-2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
Supplementary Figure Legends 1-2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
View article: Supplementary Figure 2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Supplementary Figure 2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
Supplementary Figure 2 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
View article: Data from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Data from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
17β-Hydroxysteroid dehydrogenase type 12 (17β-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). 17β-HSD12 expression was also reported in breast carcinoma…
View article: Supplementary Table 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
Supplementary Table 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Open
Supplementary Table 1 from 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis
View article: Supplementary Figure 2 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Supplementary Figure 2 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Supplementary Figure 2 from In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
View article: Data from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Data from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Studies with tracking of single nanoparticles are providing new insights into the interactions and processes involved in the transport of drug carriers in living mice. Here, we report the tracking of a single particle quantum dot (Qdot) co…
View article: Supplementary Figure 1 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Supplementary Figure 1 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Supplementary Figure 1 from In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
View article: Supplementary Figure 3 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Supplementary Figure 3 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Supplementary Figure 3 from In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
View article: Supplementary Figure 1 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
Supplementary Figure 1 from <i>In vivo</i> Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice Open
Supplementary Figure 1 from In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
View article: Evidence of Ultrasound Screening in age 40-49
Evidence of Ultrasound Screening in age 40-49 Open
乳がん検診の目的は乳がん死亡率の減少であり，検診方法として政策に反映するためには死亡率減少のエビデンスが必須とされてきた。乳がんは発病からその予後が確定するまでの期間が比較的長期間にわたるため，科学的研究の成果の確定を待つことは，今現在検診を受けるべき世代が最新の医療技術による恩恵を受けられない懸念が生じる。令和になって早期発見，早期治療そのものを利益と考え，また低侵襲の治療や異常なしと判定された場合の安心感も利益に含める方向に有効性の概念が広がってきている。４０代の乳がん…
View article: Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography
Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography Open
NIPH Clinical Trial Identifier: UMIN000000757.
View article: TP53 signature diagnostic system using multiplex reverse transcription–polymerase chain reaction system enables prediction of prognosis of breast cancer patients
TP53 signature diagnostic system using multiplex reverse transcription–polymerase chain reaction system enables prediction of prognosis of breast cancer patients Open
Background TP53 status based on TP53 signature, a gene expression profile to determine the presence or absence of TP53 mutation, is an independent prognostic factor of breast cancer. The purpose of this study was to develop a simple diagno…
View article: Aiming for the best screening method
Aiming for the best screening method Open
マンモグラフィ検診は有効性の証明された唯一の検診方法であり，わが国でも２０００年から対策型検診として推奨され，２０年が経過した。マンモグラフィ検診では５０歳以上の年代と比較して４０歳代では検診精度が低下し，比較的不利益が大きいことが知られている。若年者でマンモグラフィの診断精度が低下する最大の理由は高濃度乳房であり，乳房構成に影響されることが少ない超音波検査はその解決策として期待されている。 ２００７年よりマンモグラフィ検診に超音波検査を追加した場合の有効性を評価する比較試…
View article: History and perspective of population-based breast cancer screening in Japan
History and perspective of population-based breast cancer screening in Japan Open
対策型がん検診の法基盤は健康増進法にあり健康増進事業として実施されている。がん検診の指針は，厚生労働省「がん検診のあり方に関する検討会」における議論を経て必要な見直しが行われている。 一方，わが国の乳がん検診の歴史は１９６０年代に遡り，１９８７年に第２次老人保健事業として問診および視触診による検診が開始された。この頃の世界の乳がん検診は，RCT で死亡率減少効果が示されたマンモグラフィ検診であった。日本でも１９９０年頃から評価研究が行われ，２０００年度から５０歳以上に，２０…
View article: The p21 levels have the potential to be a monitoring marker for ribociclib in breast cancer
The p21 levels have the potential to be a monitoring marker for ribociclib in breast cancer Open
Although cyclin-dependent kinase (CDK) 4/6 inhibitors have exhibited remarkable results for patients with estrogen receptor (ER)-positive breast cancer in clinical trials, the mechanism of CDK4/6 inhibitor resistance remains unclear. Thus,…
View article: Automated Quantification of Extranuclear ERα Using Phosphor-Integrated Dots for Predicting Endocrine Therapy Resistance in HR+/HER2− Breast Cancer
Automated Quantification of Extranuclear ERα Using Phosphor-Integrated Dots for Predicting Endocrine Therapy Resistance in HR+/HER2− Breast Cancer Open
In addition to genomic signaling, Estrogen receptor alpha (ERα) is associated with cell proliferation and survival through extranuclear signaling contributing to endocrine therapy (ET) resistance. However, the relationship between extranuc…
View article: The impact of J-START for dense breast
The impact of J-START for dense breast Open
高濃度乳房ではマンモグラフィによる乳癌検診の精度が低下することが知られており，社会問題としてクローズアップされている。その対応として追加検査の必要性などが取り沙汰されているが，その候補となる超音波検査に関しても，検診で思考した場合の死亡率減少効果に関するエビデンスは存在しない。J―START は高濃度乳房に特化した研究ではないが，４０歳代の比較的高濃度乳房が多い世代を対象としており，高濃度乳房と乳癌検診，超音波検査に関する多くの知見が得られている。 今回宮城県対がん協会でJ…
View article: Automated Quantification of Extranuclear Oestrogen Receptor Alpha Using Phosphor-Integrated Dots for Predicting Endocrine Therapy Resistance in Hormone Receptor-Positive HER2-Negative Breast Cancer
Automated Quantification of Extranuclear Oestrogen Receptor Alpha Using Phosphor-Integrated Dots for Predicting Endocrine Therapy Resistance in Hormone Receptor-Positive HER2-Negative Breast Cancer Open
View article: Application of Large Electronic Medical Database for Detecting Undiagnosed Patients in the General Population
Application of Large Electronic Medical Database for Detecting Undiagnosed Patients in the General Population Open
Clinical application of accumulated medical big data is a hot topic in medical informatics. Not only for suggesting possible diagnoses in each individual, large medical database can be possibly used for detecting undiagnosed patients in th…