Naoki Okada
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View article: Clinical effects of the oral administration of Astragali Radix extract in patients with chronic kidney disease
Clinical effects of the oral administration of Astragali Radix extract in patients with chronic kidney disease Open
Background The decline in glomerular filtration rate is an unfortunate consequence of chronic kidney disease (CKD). People diagnosed with CKD are limited to managing the illness with a combination of lifestyle changes and pharmaceutical ag…
View article: Clinical Characteristics of Difficult‐To‐Treat Allergic Bronchopulmonary Aspergillosis and Its Prediction Score
Clinical Characteristics of Difficult‐To‐Treat Allergic Bronchopulmonary Aspergillosis and Its Prediction Score Open
Background and Objective Administration of oral corticosteroids and/or azole antifungals for 4–6 months remains the standard treatment for allergic bronchopulmonary aspergillosis (ABPA). This study investigated the clinical characteristics…
View article: HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells
HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells Open
Myeloid-derived suppressor cells (MDSCs) play a critical role in cancer progression and resistance, thus representing promising targets for immunotherapy. Despite the established role of histone deacetylases (HDACs) in epigenetic regulatio…
View article: Treatment of allergic bronchopulmonary aspergillosis with biologics
Treatment of allergic bronchopulmonary aspergillosis with biologics Open
View article: Adoptively Transferred Myeloid-Derived Suppressor Cells Decrease Influenza A Virus Infection Mortality in a Mouse Model
Adoptively Transferred Myeloid-Derived Suppressor Cells Decrease Influenza A Virus Infection Mortality in a Mouse Model Open
In humans, influenza A virus (IAV) causes mild to severe respiratory disease, posing a major threat to public health worldwide. Increasing evidence suggests that myeloid-derived suppressor cells (MDSCs) are involved in viral infection outc…
View article: Two Cases of Orthostatic Dysregulation Successfully Treated with Shakanzoto
Two Cases of Orthostatic Dysregulation Successfully Treated with Shakanzoto Open
View article: Clinical characteristics of allergic bronchopulmonary mycosis caused by <i>Schizophyllum commune</i>
Clinical characteristics of allergic bronchopulmonary mycosis caused by <i>Schizophyllum commune</i> Open
Background Allergic bronchopulmonary mycosis (ABPM) is an allergic disease caused by type I and type III hypersensitivity to environmental fungi. Schizophyllum commune , a basidiomycete fungus, is one of the most common fungi that causes n…
View article: A Case of Von Hippel-Lindau Disease With Recurrence of Paraganglioma and No Other Associated Symptoms: The Importance of Genetic Testing and Establishing Follow-Up Policies
A Case of Von Hippel-Lindau Disease With Recurrence of Paraganglioma and No Other Associated Symptoms: The Importance of Genetic Testing and Establishing Follow-Up Policies Open
View article: EXTH-53. VEGFR2-SPECIFIC CAR-T CELLS SHOW IMPROVED TUMOR INFILTRATION IN SYNGENEIC MOUSE GLIOMA MODELS
EXTH-53. VEGFR2-SPECIFIC CAR-T CELLS SHOW IMPROVED TUMOR INFILTRATION IN SYNGENEIC MOUSE GLIOMA MODELS Open
BACKGROUND Chimeric antigen receptor (CAR-)T cell therapy, a powerful immunotherapy against hematological malignancies, has so far limited efficiency in solid tumors. Also in glioblastoma, a major obstacle remains limited infiltration of C…
View article: Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice
Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice Open
Viral pneumonia is a global health burden with a high mortality rate, especially in the elderly and in patients with underlying diseases. Recent studies have found that myeloid-derived suppressor cells (MDSCs) are abundant in these patient…
View article: Variations in soil nutrient availabilities and foliar nutrient concentrations of trees between temperate monsoon karst and non‐karst forest ecosystems on Mount Ibuki in Japan
Variations in soil nutrient availabilities and foliar nutrient concentrations of trees between temperate monsoon karst and non‐karst forest ecosystems on Mount Ibuki in Japan Open
Plants growing on karst soils, which are characterized by high pH (>7.5–8.0) and low phosphorus availability, often exhibit phosphorus deficiency. However, little is known about the soil nutrient availabilities and foliar nutrient concentr…
View article: Front Cover: Porous Organic Salts Composed of Terphenyl Sulfonic Acid and Their Bottleneck Designability (Eur. J. Org. Chem. 30/2023)
Front Cover: Porous Organic Salts Composed of Terphenyl Sulfonic Acid and Their Bottleneck Designability (Eur. J. Org. Chem. 30/2023) Open
The Front Cover shows the porous organic salt with “gate-like” bottlenecks that exhibits gas separation properties depending on the size of the bottlenecks. Oxygen molecules (shown in red) are smaller than the gate size and can easily get …
View article: Allergic bronchopulmonary aspergillosis with atopic, nonatopic, and sans asthma—Factor analysis
Allergic bronchopulmonary aspergillosis with atopic, nonatopic, and sans asthma—Factor analysis Open
Background Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence or absence of asthma, either atopic or nonatopic. We have tried to explore the essential components in the pathogenesis of the disease, which are either con…
View article: Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice
Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice Open
Viral pneumonia is a global health burden with a high mortality rate, especially in the elderly and in patients with underlying diseases. Recent studies have found that myeloid-derived suppressor cells (MDSCs) are abundant in these patient…
View article: HDAC1-3 inhibition reduces CCR2 expression and immunosuppressive function of myeloid-derived suppressor cells
HDAC1-3 inhibition reduces CCR2 expression and immunosuppressive function of myeloid-derived suppressor cells Open
Myeloid-derived suppressor cells (MDSCs) play a critical role in cancer progression and resistance, making them significant targets for cancer immunotherapy. Although epigenetic regulation by histone deacetylases (HDACs) regulates cell fat…
View article: A Method to Evaluate and Eliminate Fungal Contamination in Household Air Conditioners
A Method to Evaluate and Eliminate Fungal Contamination in Household Air Conditioners Open
Background. Allergic fungal airway diseases, such as asthma and allergic bronchopulmonary mycosis (ABPM), are often difficult to manage with medical treatment alone; therefore, environmental fungal exposure should be accurately evaluated a…
View article: Real-world efficacy of anti-IL-5 treatment in patients with allergic bronchopulmonary aspergillosis
Real-world efficacy of anti-IL-5 treatment in patients with allergic bronchopulmonary aspergillosis Open
View article: A Case of Right Breast Cancer Diagnosed with Malignant Adenomyoepithelioma after Resection of the Metastases
A Case of Right Breast Cancer Diagnosed with Malignant Adenomyoepithelioma after Resection of the Metastases Open
症例は初診時56歳の女性．右乳癌に対して乳房全切除術およびセンチネルリンパ節生検を実施．病理組織診断はinvasive ductal carcinoma，（papillotubular），NG3，ER（-），PgR（-），Ki-67=20％，HER2（-）;pT1b （9mm），pN0，M0;Stage Iで，浸潤癌に隣接して腺筋上皮腫が認められた．術後補助療法なしで経過観察していた．術後4年後のCTで右肺S6に分葉状・多結節様腫瘍を認め，その4カ月後に他施設で胸腔鏡下右肺…
View article: Shrinking Behavior of Thermo-And Magnetic-Responsive Gels Under External Magnetic Fields
Shrinking Behavior of Thermo-And Magnetic-Responsive Gels Under External Magnetic Fields Open
View article: Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism
Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism Open
Myeloid-derived suppressor cells (MDSCs), which accumulate in tumor bearers, are known to suppress anti-tumor immunity and thus promote tumor progression. MDSCs are considered a major cause of resistance against immune checkpoint inhibitor…
View article: Binding and Efficacy of Anti-Robo4 CAR-T Cells against Solid Tumors
Binding and Efficacy of Anti-Robo4 CAR-T Cells against Solid Tumors Open
Chimeric antigen receptor expression T (CAR-T) cell therapy has been shown be efficacious against relapsed/refractory B-cell malignant lymphoma and has attracted attention as an innovative cancer treatment. However, cells of solid tumors a…
View article: <scp>IFN</scp>‐α/β‐mediated <scp>NK2R</scp> expression is related to the malignancy of colon cancer cells
<span>IFN</span>‐α/β‐mediated <span>NK2R</span> expression is related to the malignancy of colon cancer cells Open
Neurokinin 2 receptor (NK2R), a G protein‐coupled receptor for neurokinin A (NKA), a tachykinin family member, regulates various physiological functions including pain response, relaxation of smooth muscle, dilation of blood vessels, and v…
View article: Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF
Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF Open
Myeloid-derived suppressor cells (MDSCs) are major immunosuppressive cells that accumulate in tumor-bearing hosts. Since MDSCs suppress anti-tumor immunity and promote tumor progression, they are promising targets for cancer immunotherapy.…
View article: The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity
The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity Open
To improve the efficacy and safety of chimeric antigen receptor (CAR)-expressing T cell therapeutics through enhanced CAR design, we analysed CAR structural factors that affect CAR-T cell function. We studied the effects of disulphide bond…
View article: Transcutaneous Administration of Imiquimod Promotes T and B Cell Differentiation into Effector Cells or Plasma Cells
Transcutaneous Administration of Imiquimod Promotes T and B Cell Differentiation into Effector Cells or Plasma Cells Open
We are interested in promoting the development of transcutaneous immunization using microneedle technology and attempting to apply an adjuvant with transcutaneous immunization to improve the efficacy and reduce the amount of antigen and nu…
View article: Severe Post-COVID-19 Organizing Pneumonia during Cancer Immunochemotherapy
Severe Post-COVID-19 Organizing Pneumonia during Cancer Immunochemotherapy Open
A 44-year-old man developed coronavirus disease 2019 (COVID-19) pneumonia during immunochemotherapy consisting of carboplatin, paclitaxel, and pembrolizumab for non-small cell lung cancer. Low-grade fever, followed by mild hypoxemia, and f…
View article: 3. Overview of NTV Unilateral Broadcast Production for Tokyo 2020
3. Overview of NTV Unilateral Broadcast Production for Tokyo 2020 Open
View article: Adjuvant Activity of CpG-Oligonucleotide Administered Transcutaneously in Combination with Vaccination Using a Self-Dissolving Microneedle Patch in Mice
Adjuvant Activity of CpG-Oligonucleotide Administered Transcutaneously in Combination with Vaccination Using a Self-Dissolving Microneedle Patch in Mice Open
In this study, we investigated the mechanism of transcutaneous adjuvant activity of the CpG-oligonucleotide (K3) in mice. Transcutaneous immunization (TCI) with an ovalbumin-loaded self-dissolving microneedle patch (OVA-sdMN) and K3-loaded…
View article: Spinal rosette-forming glioneuronal tumor: First case in a young child
Spinal rosette-forming glioneuronal tumor: First case in a young child Open
View article: Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade
Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade Open