Namki Hong
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View article: Spine age derived from DXA vertebral fracture assessment images predicts incident fractures and mortality: the Manitoba Bone Mineral Density Registry
Spine age derived from DXA vertebral fracture assessment images predicts incident fractures and mortality: the Manitoba Bone Mineral Density Registry Open
Biological age may better predict health outcomes than chronological age by capturing individual heterogeneity in aging. We investigated whether accelerated spine aging, estimated from DXA vertebral fracture assessment (VFA) using deep lea…
View article: Challenges in Evaluation and Management in Tumor-Induced Osteomalacia: A Retrospective Institutional and Literature-Based Scoping Review in Korean Patients
Challenges in Evaluation and Management in Tumor-Induced Osteomalacia: A Retrospective Institutional and Literature-Based Scoping Review in Korean Patients Open
Background: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by hypophosphatemia and osteomalacia, resulting from excessive production of fibroblast growth factor 23 by mesenchymal tumors. Although various i…
View article: Entropy and Human Aging
Entropy and Human Aging Open
Entropy, a measure of disorder and randomness, is an essential feature of thermodynamics, chemistry, and information theory, but there has been little study of entropy in human aging. Entropy arises from random molecular interactions or ot…
View article: Serum Phosphorus Is a Fast and Highly Sensitive Marker Predictive of a Complete Cure of Tumor-Induced Osteomalacia
Serum Phosphorus Is a Fast and Highly Sensitive Marker Predictive of a Complete Cure of Tumor-Induced Osteomalacia Open
Background/Objectives: Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome caused by phosphaturic mesenchymal tumors (PMTs). FGF23, which is overproduced by PMTs, causes hypophosphatemia and osteomalacia, ultimately…
View article: Dual-energy X-ray absorptiometry based biofidelic finite element models for simulating falls to the hip: Impact of trochanteric soft tissue thickness on fracture risk
Dual-energy X-ray absorptiometry based biofidelic finite element models for simulating falls to the hip: Impact of trochanteric soft tissue thickness on fracture risk Open
Biofidelic finite element models built using image data captures population-based differences in hip fracture risk for the three main ethnic groups in Singapore. In the absence of 3D optical scans, predicting soft tissue shapes based on wh…
View article: Bisphosphonates as a Tacrolimus-Sparing Strategy in Kidney Transplantation: Insights from a Retrospective Analysis
Bisphosphonates as a Tacrolimus-Sparing Strategy in Kidney Transplantation: Insights from a Retrospective Analysis Open
The use of bisphosphonate was associated with favorable graft outcomes, even with low TTLs. Incorporating bisphosphonate into a conventional immunosuppressant regimen may potentially reduce tacrolimus requirement.
View article: SAT-771 Risk stratification of atypical parathyroid tumor using transcriptome sequencing
SAT-771 Risk stratification of atypical parathyroid tumor using transcriptome sequencing Open
Disclosure: H. Park: None. M. Kim: None. S. Jo: None. G. Kim: None. J. Jeong: None. N. Hong: None. S. Kim: None. Y. Rhee: None. Context: Atypical parathyroid tumors (APTs) are a rare subtype of parathyroid neoplasms characterized by diagno…
View article: OR10-04 Evaluation of the Efficacy of ZOledronic Acid Administered Once or Twice After Different Durations of DenosuMab Treatment in Postmenopausal Women with Osteoporosis (ZOOM): A Prospective, Single-Center, Open-Label, Parallel, Phase IV Study
OR10-04 Evaluation of the Efficacy of ZOledronic Acid Administered Once or Twice After Different Durations of DenosuMab Treatment in Postmenopausal Women with Osteoporosis (ZOOM): A Prospective, Single-Center, Open-Label, Parallel, Phase IV Study Open
Disclosure: J. Park: None. S. Cho: None. N. Hong: None. Y. Rhee: None. Objectives: This study evaluates the efficacy of zoledronic acid in preventing bone loss in postmenopausal women with osteoporosis who transitioned off denosumab after …
View article: SAT-787 Lower Muscle Area and Immunosuppressive Agents are Associated with Greater Bone Loss in Liver Transplant Recipients
SAT-787 Lower Muscle Area and Immunosuppressive Agents are Associated with Greater Bone Loss in Liver Transplant Recipients Open
Disclosure: S. Baek: None. J. Park: None. S. Cho: None. N. Hong: None. E. Min: None. J. Lee: None. D. Joo: None. Y. Rhee: None. Liver transplantation is a critical treatment for end-stage liver disease, but musculoskeletal complications si…
View article: Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality
Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality Open
Entropy, characterized by increased disorder throughout biological systems, can be quantified by homeostatic dysregulation (HD). One potential measure of HD is the dispersion of points from a normal value, approximated at the individual le…
View article: Epidemiology and clinical outcomes of clinically suspected multiple endocrine neoplasia type 1 in South Korea: a nationwide cohort study
Epidemiology and clinical outcomes of clinically suspected multiple endocrine neoplasia type 1 in South Korea: a nationwide cohort study Open
Background Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disorder characterized by multiorgan endocrine tumors, primarily affecting the parathyroid glands, pituitary, and pancreas. Despite its clinical significance, the e…
View article: Association Between Waist‐to‐Height Ratio Estimated Fat Mass Categories and Incident Fractures
Association Between Waist‐to‐Height Ratio Estimated Fat Mass Categories and Incident Fractures Open
Background Although obesity is a well‐known risk factor for various metabolic disorders, its impact on fracture risk remains uncertain. The inconsistency in findings may be due to the fact that most studies have relied solely on body mass …
View article: Transcriptome sequencing reveals distinct atypical parathyroid tumor subtypes
Transcriptome sequencing reveals distinct atypical parathyroid tumor subtypes Open
Atypical parathyroid tumors (APTs) are a rare subtype of parathyroid neoplasms characterized by diagnostic challenges and an uncertain prognosis. This study aimed to validate the subtypes of APTs using transcriptome sequencing. We applied …
View article: Comprehensive Evaluation of Treatment Patterns in Postmenopausal Patients with Osteoporosis without Fractures: Insights from Tertiary Care Institutions and Nationwide OMOP-CDM Data
Comprehensive Evaluation of Treatment Patterns in Postmenopausal Patients with Osteoporosis without Fractures: Insights from Tertiary Care Institutions and Nationwide OMOP-CDM Data Open
Background: Osteoporosis is a global health concern. Despite emerging treatment options for this condition, limited data are available on hospital practices in South Korea. This study addresses the need for a hospital network database that…
View article: Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study
Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study Open
Objectives The feasibility of dental implants in patients with osteoporosis remains controversial, with limited prospective studies on quantitative changes in bone mineral density (BMD) and bone turnover markers (BTMs). This study assessed…
View article: Spine age estimation using deep learning in lateral spine radiographs and DXA VFA to predict incident fracture and mortality
Spine age estimation using deep learning in lateral spine radiographs and DXA VFA to predict incident fracture and mortality Open
Background Spine age estimated from lateral spine radiographs and DXA vertebral fracture assessments (VFAs) could be associated with fracture and mortality risk. Methods In the VERTE-X cohort (n=10,341, age 40 or older; derivation set) and…
View article: Low Skeletal Muscle Radiodensity Predicts Response to CDK4/6 Inhibitors Plus Aromatase Inhibitors in Advanced Breast Cancer
Low Skeletal Muscle Radiodensity Predicts Response to CDK4/6 Inhibitors Plus Aromatase Inhibitors in Advanced Breast Cancer Open
Background Recent evidence indicates that a dysregulated host metabolism influences treatment outcomes in patients with breast cancer. We investigated the association of computed tomography (CT)‐derived body composition indices with therap…
View article: Digital Phenotyping of Rare Endocrine Diseases Across International Data Networks and the Effect of Granularity of Original Vocabulary
Digital Phenotyping of Rare Endocrine Diseases Across International Data Networks and the Effect of Granularity of Original Vocabulary Open
Our findings demonstrate the feasibility of developing digital phenotyping of rare endocrine diseases and highlight the importance of implementing SNOMED CT in routine clinical practice to provide granularity for research.
View article: Discriminatory Accuracy of Fracture Risk Assessment Tool in Asian Populations: A Systematic Review and Meta-Analysis
Discriminatory Accuracy of Fracture Risk Assessment Tool in Asian Populations: A Systematic Review and Meta-Analysis Open
Background: This review explores the discriminative ability of fracture risk assessment tool (FRAX) in major osteoporotic fracture (MOF) and hip fracture (HF) risk prediction and the densitometric diagnosis of osteoporosis in Asian populat…
View article: Association of Delayed Denosumab Dosing with Increased Risk of Fractures: A Population-Based Retrospective Study
Association of Delayed Denosumab Dosing with Increased Risk of Fractures: A Population-Based Retrospective Study Open
Background: Inhibitory effects of denosumab on bone remodeling are reversible and disappear once treatment is discontinued. Herein, we examined whether and to what extent delayed denosumab administration is also associated with fracture ri…
View article: Validating Machine Learning Models Against the Saline Test Gold Standard for Primary Aldosteronism Diagnosis
Validating Machine Learning Models Against the Saline Test Gold Standard for Primary Aldosteronism Diagnosis Open
In our discussion, we address both the strengths and limitations of our study. Although the machine learning models demonstrated superior performance in predicting primary aldosteronism, the generalizability of these findings may be limite…
View article: Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution
Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution Open
Current pharmacologic treatments for atherosclerosis do not completely protect patients; additional protection can be achieved by dietary modifications, such as a low-cholesterol/low-fat diet (LCLFD), that mediate plaque stabilization and …