Nikolay E. Polyakov
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View article: Photoinduced Formation of BODIPY Radical Cation in Meso‐Methyl‐BODIPY Photocage: Direct Evidence with Chemically Induced Dynamic Nuclear Polarization Technique
Photoinduced Formation of BODIPY Radical Cation in Meso‐Methyl‐BODIPY Photocage: Direct Evidence with Chemically Induced Dynamic Nuclear Polarization Technique Open
Light‐responsive molecules that can release drugs upon light absorption have attracted significant interest in chemistry and biology. BODIPY‐based photoremovable protecting groups, or photocages, have recently emerged as especially promisi…
View article: Special Issue “The Role of Carotenoids in Health and Disease”
Special Issue “The Role of Carotenoids in Health and Disease” Open
Carotenoids represent a ubiquitous and critically important class of natural isoprenoid pigments, synthesized de novo by plants, algae, and photosynthetic bacteria [...]
View article: Correction: Magin et al. Impact of Non-Covalent Interactions of Chiral Linked Systems in Solution on Photoinduced Electron Transfer Efficiency. Int. J. Mol. Sci. 2023, 24, 9296
Correction: Magin et al. Impact of Non-Covalent Interactions of Chiral Linked Systems in Solution on Photoinduced Electron Transfer Efficiency. Int. J. Mol. Sci. 2023, 24, 9296 Open
The journal’s Editorial Office and Editorial Board are jointly issuing a resolution and removal of the Journal Notice linked to this article [...]
View article: Novel Anthraquinone Derivatives and Their Complexes with Metal Ions with Anticancer Activity: Structure/Redox and Chelation Activity Correlations
Novel Anthraquinone Derivatives and Their Complexes with Metal Ions with Anticancer Activity: Structure/Redox and Chelation Activity Correlations Open
Background/Objectives: Some specific anthraquinone derivatives (AQs) are known to be used widely as effective chemotherapeutic agents in the treatment of cancer. However, their fundamental shortcoming is the high rate of cardiotoxicity obs…
View article: Lipid-mediated effect of glycyrrhizin on the properties of the transmembrane domain of the E-protein of the SARS-CoV-2 virus
Lipid-mediated effect of glycyrrhizin on the properties of the transmembrane domain of the E-protein of the SARS-CoV-2 virus Open
The interaction of glycyrrhizin with the transmembrane domain of the E-protein of the SARS-CoV-2 virus (E-protein Trans-Membrane domain, ETM) in a homogeneous aqueous solution and in a model lipid membrane was studied using the selective n…
View article: PREPARATION AND PHYSICOCHEMICAL PROPERTIES OF SUPRAMOLECULAR COMPLEXES OF ECDYSTERONE
PREPARATION AND PHYSICOCHEMICAL PROPERTIES OF SUPRAMOLECULAR COMPLEXES OF ECDYSTERONE Open
The supramolecular complexes of ecdysterone (20E), an active ingredient of many adaptogenic and anabolic drugs, with 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD) and disodium salt of glycyrrhizic acid (Na2GA) were prepared by mechanochemical…
View article: Increase of solubility and transmembrane permeability of niclosamide from its mechanochemically synthesized solid dispersions
Increase of solubility and transmembrane permeability of niclosamide from its mechanochemically synthesized solid dispersions Open
More than 4.5 billion people worldwide are affected by parasitic diseases, with helminth infections accounting for 99% of the total number. Niclosamide (NS) is a weakly acidic active pharmaceutical ingredient (API) used to treat helminth i…
View article: Increased Free Radical Generation during the Interaction of a Quinone-Quinoline Chelator with Metal Ions and the Enhancing Effect of Light
Increased Free Radical Generation during the Interaction of a Quinone-Quinoline Chelator with Metal Ions and the Enhancing Effect of Light Open
Schiff bases and similar molecules forming metal complexes may cause redox effects, which may also be influenced by light. Anthraquinones such as doxorubicin and idarubicin are widely used antitumor agents, which can generate reactive oxyg…
View article: The Endless World of Carotenoids—Structural, Chemical and Biological Aspects of Some Rare Carotenoids
The Endless World of Carotenoids—Structural, Chemical and Biological Aspects of Some Rare Carotenoids Open
Carotenoids are a large and diverse group of compounds that have been shown to have a wide range of potential health benefits. While some carotenoids have been extensively studied, many others have not received as much attention. Studying …
View article: Impact of Non-Covalent Interactions of Chiral Linked Systems in Solution on Photoinduced Electron Transfer Efficiency
Impact of Non-Covalent Interactions of Chiral Linked Systems in Solution on Photoinduced Electron Transfer Efficiency Open
It is well-known that non-covalent interactions play an essential role in the functioning of biomolecules in living organisms. The significant attention of researchers is focused on the mechanisms of associates formation and the role of th…
View article: Metal Complexes of Omadine (N-Hydroxypyridine-2-thione): Differences of Antioxidant and Pro-Oxidant Behavior in Light and Dark Conditions with Possible Toxicity Implications
Metal Complexes of Omadine (N-Hydroxypyridine-2-thione): Differences of Antioxidant and Pro-Oxidant Behavior in Light and Dark Conditions with Possible Toxicity Implications Open
Omadine or N-hydroxypyridine-2-thione and its metal complexes are widely used in medicine and show bactericidal, fungicidal, anticancer, and photochemical activity. The redox activity of omadine complexes with iron, copper, and zinc on lip…
View article: The Interaction of the Transmembrane Domain of SARS-CoV-2 E-Protein with Glycyrrhizic Acid in Lipid Bilayer
The Interaction of the Transmembrane Domain of SARS-CoV-2 E-Protein with Glycyrrhizic Acid in Lipid Bilayer Open
The interaction of the transmembrane domain of SARS-CoV-2 E-protein with glycyrrhizic acid in a model lipid bilayer (small isotropic bicelles) is demonstrated using various NMR techniques. Glycyrrhizic acid (GA) is the main active componen…
View article: Physicochemical Approaches to the Study of the Antioxidant Activity of Glycyrrhizin
Physicochemical Approaches to the Study of the Antioxidant Activity of Glycyrrhizin Open
The review presents an attempt to collect and systematize the available data on the antioxidant activity of glycyrrhizin obtained by various physicochemical methods and to stimulate further discussions on the mechanisms of its activity and…
View article: Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems
Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems Open
Natural bioactive compounds have recently emerged as a current strategy for Alzheimer’s disease treatment. Carotenoids, including astaxanthin, lycopene, lutein, fucoxanthin, crocin and others are natural pigments and antioxidants, and can …
View article: Photoinduced Processes in Lysine-Tryptophan-Lysine Tripeptide with L and D Tryptophan
Photoinduced Processes in Lysine-Tryptophan-Lysine Tripeptide with L and D Tryptophan Open
Optical isomers of short peptide Lysine-Tryptophan-Lysine (Lys-{L/D-Trp}-Lys) and Lys-Trp-Lys with an acetate counter-ion were used to study photoinduced intramolecular and intermolecular processes of interest in photobiology. A comparison…
View article: Transport reform in St. Petersburg in the context of a smart city development strategy
Transport reform in St. Petersburg in the context of a smart city development strategy Open
The paper evaluates the results of the transport reform in St. Petersburg. It has been established that the current trends in the development of the urban economy in the modern world are being implemented in line with a smart city developm…
View article: New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique
New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique Open
Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous ant…
View article: Preparation of DNC Solid Dispersion by a Mechanochemical Method with Glycyrrhizic Acid and Polyvinylpyrrolidone to Enhance Bioavailability and Activity
Preparation of DNC Solid Dispersion by a Mechanochemical Method with Glycyrrhizic Acid and Polyvinylpyrrolidone to Enhance Bioavailability and Activity Open
To exploit aqueous-soluble formulation and improve the anticoccidial activity of 4,4′-dinitrocarbanilide (DNC, active component of nicarbazin), this paper prepared DNC/GA/PVP K30 solid dispersion (SD) with glycyrrhizic acid (GA) and polyvi…
View article: Stereoselectivity of Interaction of Nonsteroidal Anti-Inflammatory Drug S-Ketoprofen with L/D-Tryptophan in Phospholipid Membranes
Stereoselectivity of Interaction of Nonsteroidal Anti-Inflammatory Drug S-Ketoprofen with L/D-Tryptophan in Phospholipid Membranes Open
The mechanisms of stereoselectivity of the interaction of chiral drugs with active sites of enzymes and cell receptors attract significant attention. The first reason is the difference in therapeutic activity of the enantiomers of the comm…
View article: Chiral Linked Systems as a Model for Understanding D-Amino Acids Influence on the Structure and Properties of Amyloid Peptides
Chiral Linked Systems as a Model for Understanding D-Amino Acids Influence on the Structure and Properties of Amyloid Peptides Open
In this review, we provide an illustration of the idea discussed in the literature of using model compounds to study the effect of substitution of L- for D-amino acid residues in amyloid peptides. The need for modeling is due to the inabil…
View article: Photoinduced Oxidation of Lipid Membranes in the Presence of the Nonsteroidal Anti-Inflammatory Drug Ketoprofen
Photoinduced Oxidation of Lipid Membranes in the Presence of the Nonsteroidal Anti-Inflammatory Drug Ketoprofen Open
The damage of cell membranes induced by photosensitive drugs has attracted the significant attention of researchers in various fields of medicine. Ketoprofen (KP) is known to be the most photosensitive among the nonsteroidal anti-inflammat…
View article: The Interplay of Ascorbic Acid with Quinones-Chelators—Influence on Lipid Peroxidation: Insight into Anticancer Activity
The Interplay of Ascorbic Acid with Quinones-Chelators—Influence on Lipid Peroxidation: Insight into Anticancer Activity Open
Ascorbic acid is a multifaceted compound that can perform both antioxidant and pro-oxidant activities in the redox reactions induced by transition metal ions, so its role in nature and especially in the human body is still the subject of d…
View article: Kidney autotransplantation: a method for treating ureteral lesions in urological and oncological practice
Kidney autotransplantation: a method for treating ureteral lesions in urological and oncological practice Open
The first successful kidney autotransplantation was performed in 1902. The technique has undergone several changes since then. The indications and surgical technique are presented in this literature review. Kidney autotransplantation is th…
View article: Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine
Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine Open
The antioxidant/pro-oxidant activity of drugs and dietary molecules and their role in the maintenance of redox homeostasis, as well as the implications in health and different diseases, have not yet been fully evaluated. In particular, the…
View article: Optical Configuration Effect on the Structure and Reactivity of Diastereomers Revealed by Spin Effects and Molecular Dynamics Calculations
Optical Configuration Effect on the Structure and Reactivity of Diastereomers Revealed by Spin Effects and Molecular Dynamics Calculations Open
The peculiarities of spin effects in photoinduced electron transfer (ET) in diastereomers of donor-acceptor dyads are considered in order to study the influence of chirality on reactivity. Thus, the spin selectivity—the difference between …