Explanipedia

Trial design of bacteriophage therapy for nontuberculous mycobacteria pulmonary disease in cystic fibrosis: The POSTSTAMP study Open

Jerry A. Nick, Stacey L. Martiniano, Valerie K. Lovell, Brian Vestal, Katie R. Poch , et al. · 2025

Bacteriophages (phages) are viruses that selectively infect bacteria and have been utilized to treat Mycobacterium abscessus (Mab) with varying success. The POSTSTAMP study is an ongoing, multi-site phage therapy protocol for treatment-ref…

Divergent host humoral innate immune response to the smooth-to-rough adaptation of Mycobacterium abscessus in chronic infection Open

Emily A. Wheeler, P. Lenhart-Pendergrass, N. Rysavy, Katie R. Poch, Silvia M. Caceres , et al. · 2025

Mycobacterium abscessus is a nontuberculous mycobacterium emerging as a significant pathogen in individuals with chronic lung diseases, including cystic fibrosis and chronic obstructive pulmonary disease. Current therapeutics have poor eff…

Prospective Analysis of urINe LAM to Eliminate NTM Sputum Screening (PAINLESS) study: Rationale and trial design for testing urine lipoarabinomannan as a marker of NTM lung infection in cystic fibrosis Open

Kara Calhoun, Emily Armantrout, Katie R. Poch, Silvia M. Caceres, Valerie K. Lovell , et al. · 2025

Background Routine screening for nontuberculous mycobacterial (NTM) lung disease is dependent on sputum cultures. This is particularly challenging in the cystic fibrosis (CF) population due to reduced sputum production and low culture sens…

Prospective Analysis of urINe LAM to Eliminate NTM Sputum Screening (PAINLESS) study: Rationale and trial design for testing urine lipoarabinomannan as a marker of NTM lung infection in cystic fibrosis Open

Kara Calhoun, Emily Armantrout, Katie R. Poch, Silvia M. Caceres, Valerie K. Lovell , et al. · 2024

Background Routine screening for nontuberculous mycobacterial (NTM) lung disease is dependent on sputum cultures. This is particularly challenging in the cystic fibrosis (CF) population due to reduced sputum production and low culture sens…

206 IL-22 binding protein: a potential target for immunomodulation in cystic fibrosis Open

C. Bojanowski, L. Kikukawa, C. MacNamara Katherine, J. Bodnar, S. Lee , et al. · 2023

Systems serology in cystic fibrosis: Anti-Pseudomonas IgG1 responses and reduced lung function Open

Shiping Lu, Kong Chen, Kejing Song, Joseph M. Pilewski, Bronwyn M. Gunn , et al. · 2023

557 Relationship between metabolomic profiles and clinical outcomes after CFTR rescue Open

Milene T. Saavedra, Silvia M. Caceres, N. Rysavy, Katie R. Poch, Julie A. Reisz , et al. · 2023

211 Systems serology in cystic fibrosis: anti-Pseudomonas IgG1 responses and reduced lung function Open

Shiping Lu, B. Gunn, N. Rysavy, Katie R. Poch, Silvia M. Caceres , et al. · 2023

Prospective evaluation of nontuberculous mycobacteria disease in cystic fibrosis: The design of the PREDICT study Open

Stacey L. Martiniano, Silvia M. Caceres, Katie R. Poch, N. Rysavy, Valerie K. Lovell , et al. · 2023

ClinicalTrials.gov Identifier: NCT02073409.

Divergent host innate immune response to the smooth-to-rough<i>M. abscessus</i>adaptation to chronic infection Open

Emily A Wheeler, P. Lenhart-Pendergrass, N. Rysavy, Katie R. Poch, Silvia M. Caceres , et al. · 2023

Mycobacterium abscessus is a nontuberculous mycobacterium emerging as a significant pathogen for individuals with chronic lung disease, including cystic fibrosis and chronic obstructive pulmonary disease. Current therapeutics have poor eff…

Deficient Complement Opsonization Impairs Mycobacterium avium Killing by Neutrophils in Cystic Fibrosis Open

P. Lenhart-Pendergrass, Kenneth C. Malcolm, Emily A. Wheeler, N. Rysavy, Katie R. Poch , et al. · 2023

Mycobacterium avium is a member of a group of bacterial species termed nontuberculous mycobacteria (NTM) that cause lung disease in certain populations, including persons with cystic fibrosis (CF). NTM infections are challenging to diagnos…

Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway Open

Jerry A. Nick, Kenneth C. Malcolm, Katherine B. Hisert, Emily A. Wheeler, N. Rysavy , et al. · 2022

Specificity of Immunoglobulin Response to Nontuberculous Mycobacteria Infection in People with Cystic Fibrosis Open

Kenneth C. Malcolm, Emily A. Wheeler, Kara Calhoun, P. Lenhart-Pendergrass, N. Rysavy , et al. · 2022

Lung infections with nontuberculous mycobacteria (NTM), and particularly Mycobacterium abscessus , a pathogen with high antibiotic resistance, are of great concern due to poor clinical outcomes and challenging detection in people with cyst…

Blood mRNA biomarkers distinguish variable systemic and sputum inflammation at treatment initiation of inhaled antibiotics in cystic fibrosis: A prospective non-randomized trial Open

Silvia M. Caceres, Linda Sanders, N. Rysavy, Katie R. Poch, Caroline R. Jones , et al. · 2022

Inhaled antibiotics control chronic airway infection and maintain respiratory health in cystic fibrosis (CF). Given variation in patient responses to inhaled antibiotics, the ability to identify distinct responder phenotypes would facilita…

Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection Open

Jerry A. Nick, Rebekah M. Dedrick, Alice Gray, Eszter K. Vladar, Bailey E. Smith , et al. · 2022

451: CF plasma lacks components for effective killing of Mycobacterium abscessus Open

Kenneth C. Malcolm, Eleanor Wheeler, P. Lenhart-Pendergrass, Katie R. Poch, N. Rysavy , et al. · 2021

402: Single-cell expression analysis of circulating adaptive immune cells after highly effective modulator therapy Open

M. Saavedra, Brian Vestal, Sarah Leach, Katie R. Poch, Sara Cáceres , et al. · 2021

475: Effect ofmycobacteriophage-induced lysis on the population dynamics of treatment-refractory Mycobacterium abscessus in the CF airway Open

Jerry A. Nick, Rebekah M. Dedrick, Graham F. Hatfull, L. Elaine Epperson, N.A. Hasan , et al. · 2021

419: Opsonization promotes efficient Mycobacterium avium killing by human neutrophils Open

P. Lenhart-Pendergrass, Kenneth C. Malcolm, Eleanor Wheeler, N. Rysavy, Katie R. Poch , et al. · 2021

527: Blood mRNA biomarkers identify inflammatory phenotypes before inhaled antibiotic therapy Open

Sara Cáceres, Linda Sanders, N. Rysavy, Katie R. Poch, Christopher R. Jones , et al. · 2021

Opsonization Promotes Efficient Mycobacterium Avium Killing by Human Neutrophils Open

P. Lenhart-Pendergrass, Kenneth C. Malcolm, Emily A. Wheeler, N. Rysavy, Katie R. Poch , et al. · 2021

Introduction: Nontuberculous mycobacteria (NTM), including Mycobacterium avium, are clinically important pathogens in the cystic fibrosis (CF) population with 5-year prevalence rates of 20% and rising.Treatment regimens for NTM are prolong…

Mycobacterium abscessus Clearance by Neutrophils Is Independent of Autophagy Open

Kerstin Pohl, Xue A. Grimm, Silvia M. Caceres, Katie R. Poch, N. Rysavy , et al. · 2020

Mycobacterium abscessus , a rapidly growing nontuberculous mycobacterium, is increasingly prevalent in chronic lung disease, including cystic fibrosis, and infections are characterized by neutrophil-dominated environments. However, mechani…

N. Rysavy YOU? Author Swipe