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View article: First Mid-infrared Detection and Modeling of a Flare from Sgr A*
First Mid-infrared Detection and Modeling of a Flare from Sgr A* Open
The time-variable emission from the accretion flow of Sgr A*, the supermassive black hole at the Galactic center, has long been examined in the radio-to-millimeter, near-infrared (NIR), and X-ray regimes of the electromagnetic spectrum. Ho…
View article: <i>CASCADES</i>, a novel <i>SOX2</i> super‐enhancer‐associated long noncoding <scp>RNA</scp>, regulates cancer stem cell specification and differentiation in glioblastoma
<i>CASCADES</i>, a novel <i>SOX2</i> super‐enhancer‐associated long noncoding <span>RNA</span>, regulates cancer stem cell specification and differentiation in glioblastoma Open
Glioblastoma is the most common primary malignant brain tumor in adults, with a median survival of just over 1 year. The failure of available treatments to achieve remission in patients with glioblastoma (GBM) has been attributed to the pr…
View article: The Evaporating Massive Embedded Stellar Cluster IRS 13 Close to Sgr A*. II. Kinematic Structure
The Evaporating Massive Embedded Stellar Cluster IRS 13 Close to Sgr A*. II. Kinematic Structure Open
The existence of two distinct and apparently unrelated populations of dusty stellar objects in the Nuclear Stellar Cluster of the Milky Way, namely IRS 13 and the S-cluster, are potentially prone to a general process describing the star fo…
View article: The JWST Galactic Center Survey -- A White Paper
The JWST Galactic Center Survey -- A White Paper Open
The inner hundred parsecs of the Milky Way hosts the nearest supermassive black hole, largest reservoir of dense gas, greatest stellar density, hundreds of massive main and post main sequence stars, and the highest volume density of supern…
View article: The Evaporating Massive Embedded Stellar Cluster IRS 13 Close to Sgr A*. I. Detection of a rich population of dusty objects in the IRS 13 cluster
The Evaporating Massive Embedded Stellar Cluster IRS 13 Close to Sgr A*. I. Detection of a rich population of dusty objects in the IRS 13 cluster Open
A detailed analysis of the Nuclear Stellar Cluster (NSC) concedes not only the existence of the Scluster with its fast-moving stars and the supermassive black hole (SMBH) Sgr A*. It also reveals an embedded region of gas and dust with an e…
View article: The Evaporating Massive Embedded Stellar Cluster IRS 13 Close to Sgr A*. I. Detection of a Rich Population of Dusty Objects in the IRS 13 Cluster
The Evaporating Massive Embedded Stellar Cluster IRS 13 Close to Sgr A*. I. Detection of a Rich Population of Dusty Objects in the IRS 13 Cluster Open
A detailed analysis of the nuclear star cluster not only concedes the existence of the S cluster, with its fast-moving stars and the supermassive black hole Sgr A*. It also reveals an embedded region of gas and dust with an exceptionally h…
View article: Supplemental Figure Legends from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Supplemental Figure Legends from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
PDF file - 95KB
View article: Supplemental Figures 1 - 9 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Supplemental Figures 1 - 9 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
PDF file - 432KB, Supplementary Figure 1: Validation of Temozolomide (TMZ) siRNA Screen. Supplementary Figure 2: Base Excision Repair correlates with IC50 of alkylating agents. Supplementary Figure 3: Loss of MPG promotes sensitivity to al…
View article: Data from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Data from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways …
View article: Supplemental Figure Legends from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Supplemental Figure Legends from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
PDF file - 95KB
View article: Data from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Data from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways …
View article: Supplemental Table 1 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Supplemental Table 1 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
PDF file - 96KB, Supplemental Table 1: Predicted phosphorylation sites for human MPG.
View article: Supplemental Methods from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Supplemental Methods from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
PDF file - 143KB
View article: Supplemental Methods from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Supplemental Methods from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
PDF file - 143KB
View article: Supplemental Figures 1 - 9 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Supplemental Figures 1 - 9 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
PDF file - 432KB, Supplementary Figure 1: Validation of Temozolomide (TMZ) siRNA Screen. Supplementary Figure 2: Base Excision Repair correlates with IC50 of alkylating agents. Supplementary Figure 3: Loss of MPG promotes sensitivity to al…
View article: Supplemental Table 1 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Supplemental Table 1 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents Open
PDF file - 96KB, Supplemental Table 1: Predicted phosphorylation sites for human MPG.
View article: Supplementary Figure S7 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S7 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S7. Foretinib reduces tumor growth in SHH medulloblastoma xenografts
View article: Supplementary Figure S7 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S7 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S7. Foretinib reduces tumor growth in SHH medulloblastoma xenografts
View article: Supplementary Figure S4 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S4 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S4. Prognostic impact of p-cMET status in SHH medulloblastomas
View article: Supplementary Figure S2 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S2 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S2. Biological pathways and processes associated with high cMET and low cMET SHH medulloblastomas
View article: Data from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Data from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Medulloblastoma is the most common malignant pediatric brain tumor, with metastases present at diagnosis conferring a poor prognosis. Mechanisms of dissemination are poorly understood and metastatic lesions are genetically divergent from t…
View article: Supplementary Figure S1 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S1 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S1. Subgroup-specific copy number aberrations in primary medulloblastomas
View article: Supplementary Figure S3 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S3 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S3. Clinicopathological correlations of SHH medulloblastomas according to p-cMET status
View article: Supplementary Table S1 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Table S1 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Table S1. Foretinib concentrations in mouse brain, mouse plasma and the brain-plasma ratio
View article: Supplementary Methods and Figure Legends from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Methods and Figure Legends from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Methods and Figure Legends
View article: Data from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Data from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Medulloblastoma is the most common malignant pediatric brain tumor, with metastases present at diagnosis conferring a poor prognosis. Mechanisms of dissemination are poorly understood and metastatic lesions are genetically divergent from t…
View article: Supplementary Figure S3 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S3 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S3. Clinicopathological correlations of SHH medulloblastomas according to p-cMET status
View article: Supplementary Figure S2 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S2 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S2. Biological pathways and processes associated with high cMET and low cMET SHH medulloblastomas
View article: Supplementary Figure S4 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S4 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S4. Prognostic impact of p-cMET status in SHH medulloblastomas
View article: Supplementary Figure S5 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Supplementary Figure S5 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma Open
Supplementary Figure S5. PDGFRÃ? pathway inhibition in foretinib treated Daoy and D425 medulloblastoma cells