N. Sadekar
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View article: Update to RIFM fragrance ingredient safety assessment, 3-octanone, CAS registry number 106-68-3
Update to RIFM fragrance ingredient safety assessment, 3-octanone, CAS registry number 106-68-3 Open
View article: Use of NAMs in a weight of evidence approach to evaluate the safety via the inhalation route of acetylated vetiver oil, in spray products
Use of NAMs in a weight of evidence approach to evaluate the safety via the inhalation route of acetylated vetiver oil, in spray products Open
Acetylated Vetiver Oil (AVO) is a fragrance ingredient. We evaluated the systemic and local toxicity of AVO via inhalation from use of cosmetic spray products. Systemic exposure after inhalation was calculated using a deterministic 2-Box m…
View article: Inhalation dosimetry and dose-response analysis of diacetyl, 2, 3-pentanedione, and acetoin using respiratory tract vapor uptake models
Inhalation dosimetry and dose-response analysis of diacetyl, 2, 3-pentanedione, and acetoin using respiratory tract vapor uptake models Open
Dose-response assessment of inhaled vapors demonstrates the utility of dosimetry models for interspecies extrapolation and chemical comparisons and how their use is an important part of risk characterization as non-animal alternatives are …
View article: A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods
A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods Open
There is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However, defined methodologies are absent for predicting local respiratory effects from inhalation exposure to irritants. The cur…
View article: Use and limitations of clinical data in the identification and classification of low molecular weight chemicals (LMWCs) as respiratory sensitizers: recommendations for improvement
Use and limitations of clinical data in the identification and classification of low molecular weight chemicals (LMWCs) as respiratory sensitizers: recommendations for improvement Open
While progress has been made in recent years, there are still no suitable and accepted in silico, in vitro, or in vivo models that can be used to accurately predict whether a chemical substance has the intrinsic proper…
View article: Responses of an In Vitro Coculture Alveolar Model for the Prediction of Respiratory Sensitizers (ALIsens®) Following Exposure to Skin Sensitizers and Non-Sensitizers
Responses of an In Vitro Coculture Alveolar Model for the Prediction of Respiratory Sensitizers (ALIsens®) Following Exposure to Skin Sensitizers and Non-Sensitizers Open
In recent years, a global increase in allergy incidence following chemical exposure has been observed. While the process of skin sensitization is well characterized through the adverse outcome pathway (AOP) framework, the immunological mec…
View article: Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) - State of the science and next steps
Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) - State of the science and next steps Open
View article: RIFM fragrance ingredient safety assessment, isopropyl 2-methylbutyrate, CAS Registry Number 66576-71-4
RIFM fragrance ingredient safety assessment, isopropyl 2-methylbutyrate, CAS Registry Number 66576-71-4 Open
View article: RIFM fragrance ingredient safety assessment, phenylacetic acid, CAS Registry Number 103-82-2
RIFM fragrance ingredient safety assessment, phenylacetic acid, CAS Registry Number 103-82-2 Open
View article: RIFM fragrance ingredient safety assessment, carvyl propionate, CAS Registry Number 97-45-0
RIFM fragrance ingredient safety assessment, carvyl propionate, CAS Registry Number 97-45-0 Open
View article: RIFM fragrance ingredient safety assessment, 8-nonenal, CAS Registry number 39770-04-2
RIFM fragrance ingredient safety assessment, 8-nonenal, CAS Registry number 39770-04-2 Open
View article: RIFM fragrance ingredient safety assessment, 4-heptenal diethyl acetal, CAS Registry Number 18492-65-4
RIFM fragrance ingredient safety assessment, 4-heptenal diethyl acetal, CAS Registry Number 18492-65-4 Open
View article: RIFM fragrance ingredient safety assessment, ethyl 3,7-dimethylocta-2,6-dienoate, CAS Registry Number 13058-12-3
RIFM fragrance ingredient safety assessment, ethyl 3,7-dimethylocta-2,6-dienoate, CAS Registry Number 13058-12-3 Open
View article: RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS Registry Number 73018-51-6
RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS Registry Number 73018-51-6 Open
View article: RIFM fragrance ingredient safety assessment, myrcenyl acetate, CAS Registry Number 1118-39-4
RIFM fragrance ingredient safety assessment, myrcenyl acetate, CAS Registry Number 1118-39-4 Open
View article: RIFM fragrance ingredient safety assessment, cedrol, CAS Registry Number 77-53-2
RIFM fragrance ingredient safety assessment, cedrol, CAS Registry Number 77-53-2 Open
View article: RIFM fragrance ingredient safety assessment, eugenyl phenylacetate, CAS Registry Number 10402-33-2
RIFM fragrance ingredient safety assessment, eugenyl phenylacetate, CAS Registry Number 10402-33-2 Open
View article: RIFM fragrance ingredient safety assessment, 5-cyclotetradecen-1-one, 3-methyl-,(5E)-, CAS Registry Number 259854-70-1
RIFM fragrance ingredient safety assessment, 5-cyclotetradecen-1-one, 3-methyl-,(5E)-, CAS Registry Number 259854-70-1 Open
View article: RIFM fragrance ingredient safety assessment, phenethyl formate, CAS Registry Number 104-62-1
RIFM fragrance ingredient safety assessment, phenethyl formate, CAS Registry Number 104-62-1 Open
View article: RIFM fragrance ingredient safety assessment, phenylethyl isoamyl ether, CAS Registry Number 56011-02-0
RIFM fragrance ingredient safety assessment, phenylethyl isoamyl ether, CAS Registry Number 56011-02-0 Open
View article: RIFM fragrance ingredient safety assessment, phenethyl benzoate, CAS Registry Number 94-47-3
RIFM fragrance ingredient safety assessment, phenethyl benzoate, CAS Registry Number 94-47-3 Open
View article: RIFM fragrance ingredient safety assessment, hexadecanolide, CAS Registry Number 109-29-5
RIFM fragrance ingredient safety assessment, hexadecanolide, CAS Registry Number 109-29-5 Open
View article: RIFM fragrance ingredient safety assessment, tetrahydro-4-methyl-2-propyl-2H-pyran-4-yl acetate, CAS Registry Number 131766-73-9
RIFM fragrance ingredient safety assessment, tetrahydro-4-methyl-2-propyl-2H-pyran-4-yl acetate, CAS Registry Number 131766-73-9 Open
View article: RIFM fragrance ingredient safety assessment, isoeugenyl ethyl ether, CAS Registry Number 7784-67-0
RIFM fragrance ingredient safety assessment, isoeugenyl ethyl ether, CAS Registry Number 7784-67-0 Open
View article: RIFM fragrance ingredient safety assessment, octyl isobutyrate, CAS Registry Number 109-15-9
RIFM fragrance ingredient safety assessment, octyl isobutyrate, CAS Registry Number 109-15-9 Open
View article: Update to RIFM fragrance ingredient safety assessment, 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-4-en-2-ol, CAS Registry Number 67801-20-1
Update to RIFM fragrance ingredient safety assessment, 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-4-en-2-ol, CAS Registry Number 67801-20-1 Open
View article: RIFM fragrance ingredient safety assessment, 3-methyl-5-phenylpent-2-enenitrile, CAS registry number 93893-89-1
RIFM fragrance ingredient safety assessment, 3-methyl-5-phenylpent-2-enenitrile, CAS registry number 93893-89-1 Open
View article: RIFM fragrance ingredient safety assessment, 2,10-Tetradecadienenitrile, (2E,10Z)-, CAS Registry Number 1958026-97-5
RIFM fragrance ingredient safety assessment, 2,10-Tetradecadienenitrile, (2E,10Z)-, CAS Registry Number 1958026-97-5 Open
View article: RIFM fragrance ingredient safety assessment, 4-ethylguaiacol, CAS Registry Number 2785-89-9
RIFM fragrance ingredient safety assessment, 4-ethylguaiacol, CAS Registry Number 2785-89-9 Open
View article: RIFM fragrance ingredient safety assessment, methyl N-methylanthranilate, CAS Registry Number 85-91-6
RIFM fragrance ingredient safety assessment, methyl N-methylanthranilate, CAS Registry Number 85-91-6 Open