GSN Koteswara Rao
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View article: Comparative analysis of Mpox clades: epidemiology, transmission dynamics, and detection strategies
Comparative analysis of Mpox clades: epidemiology, transmission dynamics, and detection strategies Open
View article: Largest cholera outbreak since Jajarkot: Lessons from Birgunj, Nepal
Largest cholera outbreak since Jajarkot: Lessons from Birgunj, Nepal Open
View article: Fabrication and Characterization of Sulforaphane Loaded Magnetic Nanoparticles
Fabrication and Characterization of Sulforaphane Loaded Magnetic Nanoparticles Open
View article: Targeting protein misfolding in Alzheimer’s disease: The emerging role of molecular chaperones
Targeting protein misfolding in Alzheimer’s disease: The emerging role of molecular chaperones Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline and the accumulation of misfolded proteins, including amyloid-beta and hyperphosphorylated tau, which impair neuronal function and prom…
View article: H5N1 resurgence in Cambodia: A warning sign of global zoonotic vulnerability
H5N1 resurgence in Cambodia: A warning sign of global zoonotic vulnerability Open
View article: Electrochemical Impedance and Surface Charge Dynamics in Alkaline Oxygen Evolution on NIFE-Based Electrocatalysts
Electrochemical Impedance and Surface Charge Dynamics in Alkaline Oxygen Evolution on NIFE-Based Electrocatalysts Open
Nickel-based catalysts are widely explored for the oxygen evolution reaction (OER) in alkaline media, yet variations in reported activity and kinetic parameters remain a challenge. This study investigates NiFe-based electrocatalysts synthe…
View article: The emergence of oropouche fever: A potential new threat?
The emergence of oropouche fever: A potential new threat? Open
View article: Rising burden of human metapneumovirus: A call for global preparedness
Rising burden of human metapneumovirus: A call for global preparedness Open
View article: Ongoing hMPV outbreaks in China and other Asian countries
Ongoing hMPV outbreaks in China and other Asian countries Open
View article: <b>Optimization and Enhancement of Oral Bioavailability of Dabrafenib as Nanobubbles Using Quality by Design Approach</b>
<b>Optimization and Enhancement of Oral Bioavailability of Dabrafenib as Nanobubbles Using Quality by Design Approach</b> Open
Background: The use of Poly (lactic-co-glycolic acid) (PLGA) nanobubbles (NBs) aimed at functioning as a delivery system that encounter solubility issues for drugs like dabrafenib (DBF), which belonged to the Biopharmaceutical Classificati…
View article: Formulation optimization of chitosan surface coated solid lipid nanoparticles of griseofulvin: A Box-Behnken design and in vivo pharmacokinetic study
Formulation optimization of chitosan surface coated solid lipid nanoparticles of griseofulvin: A Box-Behnken design and in vivo pharmacokinetic study Open
Solid lipid nanoparticles (SLNs) are becoming increasingly favored for their robust biocompatibility and their capacity to enhance drug solubility, particularly for drugs with limited water solubility. This study delves into the effectiven…
View article: Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing
Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing Open
Background: The topical administration of anti-fungal drugs by Solid Lipid Nanoparticles (SLNs) has enormous potential. This study aimed to develop a topical 5-flucytosine-loaded SLNs gel to improve the efficacy of the well-known anti-fung…
View article: Microneedle technology- an insight into advancements, latest scholarly and patent data
Microneedle technology- an insight into advancements, latest scholarly and patent data Open
Microneedles (MN) have been used to deliver small molecular weight drugs, nucleotides, DNA, peptides, proteins, and even viruses that have been turned off. Over the past ten years, different kinds of MN have been made using several differe…
View article: QbD driven targeted pulmonary delivery of dexamethasone-loaded chitosan microspheres: Biodistribution and pharmacokinetic study
QbD driven targeted pulmonary delivery of dexamethasone-loaded chitosan microspheres: Biodistribution and pharmacokinetic study Open
View article: Investigation of Nootropic and Neuroprotective Activity of Myristica malabarica Bark Extracts on STZ induced Cognitive Impairment in Experimental Animals
Investigation of Nootropic and Neuroprotective Activity of Myristica malabarica Bark Extracts on STZ induced Cognitive Impairment in Experimental Animals Open
The present study aims to assess the Myristica malabarica Bark (MM) extracts in the diabetes-induced cognitive impaired rat model for its nootropic and neuroprotective activity. Memory enhancing activity was evaluated by Y maze and Morris …
View article: Anti-obesity and Antihyperlipidemic Activity of <i>Ougeinia oojeinensis</i> (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals
Anti-obesity and Antihyperlipidemic Activity of <i>Ougeinia oojeinensis</i> (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals Open
The present study was planned to assess the anti-obesity efficacy of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Ougeinia oojeinensis (Roxb.) belonging to the family Fabaceae. The soxhlation method was employed to …
View article: Anti-obesity and hypolipidemic activityofPithecellobium dulceagainst high-fatdiet-induced obesity in experimentalanimals
Anti-obesity and hypolipidemic activityofPithecellobium dulceagainst high-fatdiet-induced obesity in experimentalanimals Open
Pithecellobium dulce (PD) (Leguminosae) is conventionally used for many diseases. The objective of this present study intended to assess the anti-obese and hypolipidemic properties of petroleum ether (PEPD), ethyl acetate (EAPD), and metha…
View article: DMPK studies in rat model for comparative evaluation of bioavailability of alpha-mangostin and its formulated solid lipid nanoparticle using a validated LC-MS/MS method
DMPK studies in rat model for comparative evaluation of bioavailability of alpha-mangostin and its formulated solid lipid nanoparticle using a validated LC-MS/MS method Open
Garcinia mangostana L., contains the xanthone ?-mangostin, which is a bioactive secondary metabolite. The Caco-2 cell line transport of ?-mangostin was explored to see whether it could be used to study oral uptake. There has been little in…
View article: Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD
Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD Open
Cubosomes, which are modified cubic phase systems, are looking very promising as a method of delivering both hydrophilic and lipophilic drugs.Transdermal delivery of cubosomes is currently gaining more importance over conventional topical …
View article: Multi-Centered Retrospective Study for the Analysis of Efficacy of Antihypertensive Drugs in End Stage Renal Disease Patients: Pre-dialysis versus Post-Dialysis
Multi-Centered Retrospective Study for the Analysis of Efficacy of Antihypertensive Drugs in End Stage Renal Disease Patients: Pre-dialysis versus Post-Dialysis Open
Cardiac problems are the foremost reason for morbidity and mortality in patients with end-stage renal disease caused by hemodialysis. Many of these patients suffer from increased blood pressure, and acceptable control of blood pressure is …
View article: Development, characterization and optimization of solid lipid nanoparticles of alpha-mangostin by central composite design approach
Development, characterization and optimization of solid lipid nanoparticles of alpha-mangostin by central composite design approach Open
Statistical Optimization of Olanzapine Ternary Solid Dispersions with Pvp K 30 and Peg 20,000 by Response Surface MethodologyAnil Katharia, Ratendra Kumar, Rajiv Sharma, Yogendra Singh, Uday Veer Singh Teotia
View article: Applications of Carbon Dots (CDs) in Drug Delivery
Applications of Carbon Dots (CDs) in Drug Delivery Open
The star of the carbon nanomaterials industry is now carbon dots (C-Dots).C-Dots are a potential tool because of their applications in imaging, environmental, catalytic, biological, and energy fields thanks to their numerous distinctive ph…
View article: Sorafenib tosylate novel drug delivery systems: Implications of nanotechnology in both approved and unapproved indications
Sorafenib tosylate novel drug delivery systems: Implications of nanotechnology in both approved and unapproved indications Open
View article: A spotlight on alkaloid nanoformulations for the treatment of lung cancer
A spotlight on alkaloid nanoformulations for the treatment of lung cancer Open
Numerous naturally available phytochemicals have potential anti-cancer activities due to their vast structural diversity. Alkaloids have been extensively used in cancer treatment, especially lung cancers, among the plant-based compounds. H…
View article: Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization
Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization Open
Pulsatile drug delivery systems have drawn attention in contemporary research for designing chronotherapeutic systems. The current work aims to design pulsatile ketorolac tromethamine tablets using compression coating for delayed delivery …
View article: Pharmacological Evaluation of Nootropic and Neuroprotective Activity of Sesbania grandiflora extracts in streptozotocin-induced diabetic model of rats
Pharmacological Evaluation of Nootropic and Neuroprotective Activity of Sesbania grandiflora extracts in streptozotocin-induced diabetic model of rats Open
View article: The Race to Replace PDE5i: Recent Advances and Interventions to Treat or Manage Erectile Dysfunction: Evidence from Patent Landscape (2016–2021)
The Race to Replace PDE5i: Recent Advances and Interventions to Treat or Manage Erectile Dysfunction: Evidence from Patent Landscape (2016–2021) Open
For a few decades, globally, erectile dysfunction (ED) has become more prominent even in young adults and represents a mounting health concern causing a significant effect on men’s quality of life. There is an expectation that by the end o…
View article: In silico Analysis of Selected Phytocompounds of Cocculus hirsutus as Potent Inhibitors of Tau Aggregation in Alzheimer's Disease
In silico Analysis of Selected Phytocompounds of Cocculus hirsutus as Potent Inhibitors of Tau Aggregation in Alzheimer's Disease Open
In the current investigation, the selected phytocompounds of Cocculus hirsutus were screened for potent tau aggregation inhibitors for Alzheimer's disease through in silico molecular docking.Approximately 19 phytocompounds from Cocculus hi…
View article: Development, Statistical Optimization and Characterization of Fluvastatin Loaded Solid Lipid Nanoparticles: A 32 Factorial Design Approach
Development, Statistical Optimization and Characterization of Fluvastatin Loaded Solid Lipid Nanoparticles: A 32 Factorial Design Approach Open
The purpose of the present research work was to design, optimize, and evaluate fluvastatin-loaded solid lipid nanoparticles (FLV-SLNPs) using 32 factorial design for enhancing the bioavailability. Fluvastatin has several disadvantages, inc…
View article: Stability indicating Rp-UPLC method development and validation for the simultaneous estimation of fosnetupitant and palonosetron in bulk and injection dosage form
Stability indicating Rp-UPLC method development and validation for the simultaneous estimation of fosnetupitant and palonosetron in bulk and injection dosage form Open
A stability indicating UPLC method has been developed and validated for the simultaneous determination of fosnetupitant and palonosetron in bulk and in injection dosage form. This combination is used for the prevention of acute and delayed…