Nancy Foldvary‐Schaefer
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View article: Impact of Caregiver Status on Academic Achievements and Family-Work Conflict
Impact of Caregiver Status on Academic Achievements and Family-Work Conflict Open
Although the caregiving burden did not directly affect academic productivity, it significantly increased FWC in US academic neurology faculty surveyed. Female CG faculty disproportionately shouldered domestic and household responsibilities…
View article: Weight changes during treatment with low-sodium oxybate in two phase 3 clinical studies in participants with narcolepsy or idiopathic hypersomnia
Weight changes during treatment with low-sodium oxybate in two phase 3 clinical studies in participants with narcolepsy or idiopathic hypersomnia Open
Open-label LXB was associated with modest weight loss in participants with narcolepsy with cataplexy or idiopathic hypersomnia.
0818 Discrepancy Between Clinical Phenotyping and ICSD-3 Criteria Contributes to Misdiagnosis in Central Disorders of Hypersomnolence Open
Introduction Central Disorders of Hypersomnolence (CDH) are classified primarily by polysomnography-multiple sleep latency test (PSG-MSLT). Lack of biomarkers, variable MSLT results in disorders other than narcolepsy type 1 (NT1) and inacc…
View article: 0852 Subjective Sleep Quality with Low-Sodium Oxybate Treatment in Idiopathic Hypersomnia: Results from the DUET Study
0852 Subjective Sleep Quality with Low-Sodium Oxybate Treatment in Idiopathic Hypersomnia: Results from the DUET Study Open
Introduction Jazz DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) is a phase 4, prospective, multicenter, single-arm, multiple-cohort, open-label study (NCT05875974) evaluating the effectiveness of low-s…
1236 Impact of Medication Use on REM Sleep Without Atonia: Differentiating Medication Effect from Depression Diagnosis Open
Introduction REM Sleep without Atonia (RSWA) is the polysomnographic biomarker of REM Sleep Behavior Disorder (RBD). RSWA is associated with serotonergic (SSRIs/SNRIs) antidepressants (ADs). The effects of other ADs and depression on RSWA …
1358 The Cleveland Clinic Hypersomnia CarePath: Preliminary Results of Adherence and Safety Monitoring Open
Introduction Patients with CNS disorders of hypersomnolence (CDH) are at increased risk of cardiovascular and other health comorbidities that require frequent monitoring, particularly in the setting of controlled substance use. A 2019-2021…
1099 Sleep Apnea-Specific Hypoxic Burden as a Predictor of Incident Heart Failure Compared to Traditional Measures Open
Introduction Apnea hypopnea index (AHI) is the prevailing measure of obstructive sleep apnea (OSA) presence and severity. Despite numerous consequences, AHI calculation measures only frequency of respiratory events. Measures which characte…
View article: 0853 Sleep Architecture with Low-Sodium Oxybate Treatment in Idiopathic Hypersomnia: Results from the DUET Study
0853 Sleep Architecture with Low-Sodium Oxybate Treatment in Idiopathic Hypersomnia: Results from the DUET Study Open
Introduction Jazz DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) is a phase 4, prospective, multicenter, single-arm, multiple-cohort, open-label study (NCT05875974) evaluating the effectiveness of low-s…
0801 Polysomnographic Characteristics Differentiating the Central Disorders of Hypersomnolence Open
Introduction Central Disorders of Hypersomnolence (CDH) are classified primarily by polysomnography-multiple sleep latency test (PSG-MSLT). Lack of biomarkers and variable MSLT results in disorders other than narcolepsy type 1 (NT1) contri…
1143 Innovations in Time Series Data Integration in a Polysomnographic Foundational Model Informing Risk Groups Open
Introduction Despite the abundance of polysomnography (PSG) data, the limited summary metrics used in existing approaches may not provide the most informative insights for clinical decision-making. We hypothesized that a new data-driven cl…
0870 Shift Work Disorder Prevalence and Associated Characteristics Using the Mobile Application SLEEP by Cleveland Clinic™ Open
Introduction Shift Work Disorder (SWD) arises from recurring work schedules overlapping typical sleep times. SWD is associated with increased risks of medical and psychiatric disorders with estimated prevalence of 2-5%, likely to be undere…
1096 Age- and Sex-Specific Relationship of Sleep Apnea-Specific Heart Rate Response and Atrial Fibrillation Incidence Open
Introduction Autonomic dysfunction (AD) is implicated in sleep apnea and atrial fibrillation (AF), however age- and sex-specific interactions are unclear. We hypothesize age- and sex-specific differences in sleep apnea-specific heart rate …
0410 Cardiovascular Disease Incidence Differs by Patient Cluster Based on Raw Polysomnography Data Foundational Model Open
Introduction Traditional sleep measures are not consistently associated with incident cardiovascular events in observational studies. We hypothesized deep learning approaches could uniquely identify distinct patient groups with varying car…
Polysomnographic sleep architectural disruption associated with atrial fibrillation development Open
Study Objectives To examine the unclear, inconsistent role of sleep architectural disruption in atrial fibrillation (AF) development. Methods Patients (age ≥ 18 years) who underwent in-laboratory sleep studies at Cleveland Clinic 2000–2015…
View article: Perceptions of Lactation Experience Among Neurology Faculty and Impact of Lactation Time on Academic Achievement at U.S. Academic Medical Centers
Perceptions of Lactation Experience Among Neurology Faculty and Impact of Lactation Time on Academic Achievement at U.S. Academic Medical Centers Open
Objective: To investigate the perceptions of lactation experiences of neurology faculty and the impact of lactation time on academic achievement. Materials and Methods: This was a cross-sectional study utilizing a survey administered acros…
Who Should Talk to Patients and How About Whether They Have Access to Sufficient, Quality Sleep? Open
Primary care clinicians are well-equipped to screen for sleep concerns, help some patients, and refer patients whose sleep troubles are more complex to specialists. Poor sleep affects nearly every organ system and influences many morbidity…
View article: Sleep disorders associated with cranial radiation—A systematic review
Sleep disorders associated with cranial radiation—A systematic review Open
Background Radiation is the standard-of-care treatment for primary brain tumors (PBTs) but may have profound effects on sleep that have not yet been fully characterized. This systematic review aims to further our understanding of radiation…
Seizure Timing and Circadian Patterns: A Comprehensive Bibliographic Review Open
Epilepsy's cyclic nature, increasingly quantified through advancements in continuous electroencephalography (cEEG), reveals robust seizure cycles including circadian, multidien, and circannual rhythms. Understanding these cycles' mechanism…
View article: Analysis of Faculty Gender and Race in Scholarly Achievements in Academic Neurology
Analysis of Faculty Gender and Race in Scholarly Achievements in Academic Neurology Open
Background: Intersection of gender and race and/or ethnicity in academic medicine is understudied; we aim to understand these factors in relation to scholarly achievements for neurology faculty. Methods: Faculty from 19 US neurology depart…
View article: Clinical considerations in the treatment of idiopathic hypersomnia
Clinical considerations in the treatment of idiopathic hypersomnia Open
Idiopathic hypersomnia typically is a chronic and potentially debilitating neurologic sleep disorder, and is characterized by excessive daytime sleepiness. In addition to excessive daytime sleepiness, idiopathic hypersomnia symptoms can in…
0570 Impact of a Sleep Apnea Management Group Clinic on PAP Adherence and PROs: A Randomized Controlled Trial Open
Introduction Positive airway pressure (PAP) is the mainstay treatment for obstructive sleep apnea (OSA), yet suboptimal adherence limits treatment effectiveness. We examined the impact of a sleep apnea management (SAM) clinic, an innovativ…
1176 Extended Polysomnography Confirms Idiopathic Hypersomnia Diagnoses: A Case Series Open
Introduction Idiopathic hypersomnia (IH) is often underdiagnosed since at least 30-40% have normal mean sleep latency tests (MSLT) and test-retest reproducibility is poor. We report two cases of IH with multiple normal sleep evaluations di…
Neighborhood Disadvantage Association with Sleep Apnea and Longitudinal Cardiovascular Events in a Large Clinical Cohort Open
Background The association between neighborhood socioeconomic disadvantage and poor cardiovascular outcomes is well established; however, less is known about its interplay with obstructive sleep apnea. Methods Adult cardiovascular disease-…
Low-Sodium Oxybate Improved Symptoms in Adults with Narcolepsy with Cataplexy: A Plain Language Summary of Publication Open
What is this summary about? This plain language summary describes a clinical study that looked at the effects of a medicine called low-sodium oxybate (or LXB; XYWAV® [calcium, magnesium, potassium, and sodium oxybates]) in adults with narc…
Sleep‐Disordered Breathing, Hypoxia, and Pulmonary Physiologic Influences in Atrial Fibrillation Open
Background We leverage a large clinical cohort to elucidate sleep‐disordered breathing and sleep‐related hypoxia in incident atrial fibrillation (AF) development given the yet unclear contributions of sleep‐related hypoxia and pulmonary ph…
0820 Integrated Polysomnographic and Sleep Symptom-Based Cluster Subtypes Associated with Incident Atrial Fibrillation Open
Introduction While sleep disorders are implicated in atrial fibrillation (AF), the interplay and overlap of these disorders in AF risk remains unclear and a risk stratification challenge. Sleep-based clusters associated with AF can account…