Hamidah Hussain
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View article: To study the burden of post tubercular obstructive airway diseases in patients visiting chest OPD at a tertiary level chest OPD in North India: a descriptive cross-sectional study
To study the burden of post tubercular obstructive airway diseases in patients visiting chest OPD at a tertiary level chest OPD in North India: a descriptive cross-sectional study Open
COPD and tuberculosis are on the rise in developing countries. There is evidence of post-tuberculosis lung function deterioration and the occurrence of obstructive airway diseases in such patient groups. Objectives: To study the burden and…
View article: Cutaneous leishmaniasis in Afghanistan
Cutaneous leishmaniasis in Afghanistan Open
Old World cutaneous leishmaniasis (OWCL) is a sand fly-transmitted skin infection caused by Leishmania species that extends from West Africa to China. Afghanistan probably has the highest burden of OWCL and is home chiefly to Leishmania tr…
View article: Age- and sex-specific care cascades to detect gaps in the care of children with tuberculosis in Bangladesh: a cohort study
Age- and sex-specific care cascades to detect gaps in the care of children with tuberculosis in Bangladesh: a cohort study Open
The largest gap observed for both sexes and among all ages was children who were not appropriately evaluated for TB despite screening positive. In our research, we highlight the value of identifying gaps in paediatric TB care to inform inn…
View article: Effects and Outcomes of Temporomandibular Joint Due to Wisdom Tooth Extraction
Effects and Outcomes of Temporomandibular Joint Due to Wisdom Tooth Extraction Open
Objective: To find out the effects and outcomes of temporomandibular joint due to wisdom tooth extraction. Study Design: A cross sectional study. Place and Duration of Study: University of Lahore Teaching Hospital and Lahore Dental Clinic,…
View article: Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis
Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis Open
Background Each year 25 000–32 000 children develop rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB), and many more require preventive treatment. Levofloxacin is a key component of RR/MDR-TB treatment and prevention, but the exi…
View article: Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study
Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study Open
Background: The United Nations high-level meeting (UNHLM) pledged to enroll 30 million in tuberculosis preventive treatment (TPT) by 2022, necessitating TPT expansion to all at tuberculosis (TB) risk. We assessed the uptake and completion …
View article: Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly IsoniazidRifapentine Regimen in Bangladesh: A CommunityBased Implementation Study
Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly IsoniazidRifapentine Regimen in Bangladesh: A CommunityBased Implementation Study Open
Background: The UNHLM pledged to enroll 30 million in TB preventive treatment (TPT) by 2022, necessitating TPT expansion to all at TB risk. We assessed uptake and completion of a 12-dose, weekly isoniazid-rifapentine (3HP) TPT regimen. Met…
View article: Two clinical prediction tools to inform rapid tuberculosis treatment decision-making in children
Two clinical prediction tools to inform rapid tuberculosis treatment decision-making in children Open
Background and Objectives In the absence of bacteriologic confirmation to diagnose tuberculosis (TB) in children, it is suggested that treatment should be initiated when sufficient clinical evidence of disease is available. However, it is …
View article: TB disease yield from household contact screening of tuberculosis index patients; a cohort study from Karachi, Pakistan
TB disease yield from household contact screening of tuberculosis index patients; a cohort study from Karachi, Pakistan Open
Nearly 40% of people affected by TB in Pakistan are not diagnosed each year. Guidelines recommend screening household contacts however, not all index patients or contacts are eligible. Therefore, many contacts who may have TB disease, rema…
View article: Scale-Up of Rifapentine and Isoniazid for Tuberculosis Prevention Among Household Contacts in 2 Urban Centers: An Effectiveness Assessment
Scale-Up of Rifapentine and Isoniazid for Tuberculosis Prevention Among Household Contacts in 2 Urban Centers: An Effectiveness Assessment Open
Background Scaling up a shorter preventive regimen such as weekly isoniazid and rifapentine (3HP) for 3 months is a priority for tuberculosis (TB) preventive treatment (TPT). However, there are limited data on 3HP acceptability and complet…
View article: Economic analysis of different throughput scenarios and implementation strategies of computer-aided detection software as a screening and triage test for pulmonary TB
Economic analysis of different throughput scenarios and implementation strategies of computer-aided detection software as a screening and triage test for pulmonary TB Open
Background Artificial Intelligence (AI) systems have demonstrated potential in detecting tuberculosis (TB) associated abnormalities from chest X-ray (CXR) images. Thus, they might provide a solution to radiologist shortages in high TB burd…
View article: Drug-Resistant Tuberculosis Treatment Outcomes among Children and Adolescents in Karachi, Pakistan
Drug-Resistant Tuberculosis Treatment Outcomes among Children and Adolescents in Karachi, Pakistan Open
Background: Significant data gaps exist for children and adolescents with drug-resistant (DR) TB, particularly from high TB incidence settings. This report provides a descriptive analysis of programmatic outcomes among children and adolesc…
View article: Tuberculosis care models for children and adolescents: a scoping review
Tuberculosis care models for children and adolescents: a scoping review Open
Strengthening decentralized services in facilities and communities can improve tuberculosis outcomes for children and adolescents. Further research is needed to identify optimal integrated and family-centred care approaches.
View article: Age-specific Clinical Presentation and Risk Factors for Extrapulmonary Tuberculosis Disease in Children
Age-specific Clinical Presentation and Risk Factors for Extrapulmonary Tuberculosis Disease in Children Open
Background: Clinical presentation for extrapulmonary tuberculosis (EPTB) in children can be variable and nonspecific, leading to delayed diagnosis, disease and death. We describe the age-specific clinical presentation and identify risk fac…
View article: Re-evaluating the merits of decentralization as a core strategy for effective delivery of drug-resistant tuberculosis care in Pakistan
Re-evaluating the merits of decentralization as a core strategy for effective delivery of drug-resistant tuberculosis care in Pakistan Open
Decentralized, person-centred models of care delivery for drug-resistant tuberculosis (DR-TB) continue to be under-resourced in high-burden TB countries. The implementation of such models—made increasingly urgent by the COVID-19 pandemic—a…
View article: Correction: Malik et al. Integrated Tuberculosis and COVID-19 Activities in Karachi and Tuberculosis Case Notifications. Trop. Med. Infect. Dis. 2022, 7, 12
Correction: Malik et al. Integrated Tuberculosis and COVID-19 Activities in Karachi and Tuberculosis Case Notifications. Trop. Med. Infect. Dis. 2022, 7, 12 Open
The authors wish to revise the second citation of reference [26] to [27] in the original article main text [...]
View article: Innovation and Evidence for Achieving TB Elimination in the Asia–Pacific Region
Innovation and Evidence for Achieving TB Elimination in the Asia–Pacific Region Open
The World Health Organization’s (WHO) END-TB strategy has set the world on course to climb the highest of medical mountains by 2035, with a targeted peak of reductions in TB deaths by 95%, TB cases by 90%, and no burdens of catastrophic ex…
View article: Effectiveness and Costs of Identification Pathways for Tuberculosis: Modelling the Impact of Dual Energy X-Ray Technology
Effectiveness and Costs of Identification Pathways for Tuberculosis: Modelling the Impact of Dual Energy X-Ray Technology Open
Background Existing screening methods for TB involve trade-offs among sensitivity, specificity and cost. Recent advances mean that dual-energy X-ray is more sensitive and only slightly more costly than conventional chest X-ray and could be…
View article: Age-specific effectiveness of a tuberculosis screening intervention in children
Age-specific effectiveness of a tuberculosis screening intervention in children Open
Objective To apply a cascade-of-care framework to evaluate the effectiveness—by age of the child—of an intensified tuberculosis patient-finding intervention. Design From a prospective screening program at four hospitals in Pakistan (2014–2…
View article: Integrated Tuberculosis and COVID-19 Activities in Karachi and Tuberculosis Case Notifications
Integrated Tuberculosis and COVID-19 Activities in Karachi and Tuberculosis Case Notifications Open
As the COVID-19 pandemic surged, lockdowns led to the cancellation of essential health services. As part of our Zero TB activities in Karachi, we adapted our approach to integrate activities for TB and COVID-19 to decrease the impact on di…
View article: Provision of Decentralized TB Care Services: A Detect–Treat–Prevent Strategy for Children and Adolescents Affected by TB
Provision of Decentralized TB Care Services: A Detect–Treat–Prevent Strategy for Children and Adolescents Affected by TB Open
In this review, we discuss considerations and successful models for providing decentralized diagnosis, treatment, and prevention services for children and adolescents. Key approaches to building decentralized capacity for childhood TB diag…
View article: Isoniazid or rifampicin preventive therapy with and without screening for subclinical TB: a modeling analysis
Isoniazid or rifampicin preventive therapy with and without screening for subclinical TB: a modeling analysis Open
Background Short-course, rifamycin-based regimens could facilitate scale-up of tuberculosis preventive therapy (TPT), but it is unclear how stringently tuberculosis (TB) disease should be ruled out before TPT use. Methods We developed a st…
View article: Triage of Persons With Tuberculosis Symptoms Using Artificial Intelligence–Based Chest Radiograph Interpretation: A Cost-Effectiveness Analysis
Triage of Persons With Tuberculosis Symptoms Using Artificial Intelligence–Based Chest Radiograph Interpretation: A Cost-Effectiveness Analysis Open
Background In settings without access to rapid expert radiographic interpretation, artificial intelligence (AI)–based chest radiograph (CXR) analysis can triage persons presenting with possible tuberculosis (TB) symptoms, to identify those…
View article: Cost-effectiveness of household contact investigation for detection of tuberculosis in Pakistan
Cost-effectiveness of household contact investigation for detection of tuberculosis in Pakistan Open
Objectives Despite WHO guidelines recommending household contact investigation, and studies showing the impact of active screening, most tuberculosis (TB) programmes in resource-limited settings only carry out passive contact investigation…
View article: Special Issue “Innovation and Evidence for Achieving TB Elimination in the Asia-Pacific Region”
Special Issue “Innovation and Evidence for Achieving TB Elimination in the Asia-Pacific Region” Open
The World Health Organization’s (WHO) END-TB strategy has set the world on course to climb the highest of medical mountains by 2035, with a targeted peak of reductions in TB deaths by 95%, TB cases by 90%, and no burden of catastrophic exp…
Integrating tuberculosis screening into antenatal visits to improve tuberculosis diagnosis and care: Results from a pilot project in Pakistan Open
TB screening is feasible and should be implemented during routine ANC visits in high-TB-burden settings. There is a need to explore a multi-faceted approach with inclusion of clinical examination and chest X-rays to diagnose TB in pregnant…
Ringing the alarm bell: Time to scale up drug-resistant tuberculosis preventive treatment Open
Preventing tuberculosis (TB) infection from progressing to TB disease is essential for a comprehensive strategy for TB elimination. Recent updates to international guidance underscore the benefits of TB preventive treatment for household c…