Noriaki Takeda
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View article: Recent advances in diagnostic and therapeutic strategies for management of dizzy patients in Japan
Recent advances in diagnostic and therapeutic strategies for management of dizzy patients in Japan Open
The present review summarized the recent advances in diagnostic and therapeutic strategies for management of dizzy patients in Japan. Standardization of diagnosis, examination, and treatment of vestibular disorders and nationwide epidemiol…
View article: Effects of zinc supplementation in combination with difructose, an enhancer of intestinal zinc absorption, on serum zinc concentration and ratio of apo-/holo-activities of angiotensin-converting enzyme in patients with refractory taste impairment
Effects of zinc supplementation in combination with difructose, an enhancer of intestinal zinc absorption, on serum zinc concentration and ratio of apo-/holo-activities of angiotensin-converting enzyme in patients with refractory taste impairment Open
The present findings suggest that malabsorption of zinc in the intestine is the primary cause of zinc deficiency in patients with refractory taste impairment. J. Med. Invest. 72 : 156-160, February, 2025.
View article: Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor
Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor Open
Previously, we have shown that pyrogallol alleviated nasal symptoms and suppressed IL-9 gene up-regulation in allergy model rats by inhibiting calcineurin/NFAT signaling. As pyrogallol has antioxidative activity, it may be responsible for …
View article: A Case of Radiation-Induced Meningioma of the Cerebellopontine Angle in a Young Man Presenting with Disequilibrium
A Case of Radiation-Induced Meningioma of the Cerebellopontine Angle in a Young Man Presenting with Disequilibrium Open
We report the case of a 15-year-old young man who presented with disequilibrium and leftward spontaneous nystagmus. Since the video head impulse test at the initial visit showed right lateral semicircular canal hypofunction, the patient wa…
View article: A Case of Downbeat Nystagmus Induced by Carbamazepine Intoxication
A Case of Downbeat Nystagmus Induced by Carbamazepine Intoxication Open
We report the case of a 33-year-old man who presented with disequilibrium and downbeat nystagmus. Balance testing showed failure of visual suppression of caloric nystagmus with insufficient optokinetic nystagmus responses, suggesting centr…
View article: Comparison of the efficacy of the Epley maneuver and repeated Dix–Hallpike tests for eliminating positional nystagmus: A multicenter randomized study
Comparison of the efficacy of the Epley maneuver and repeated Dix–Hallpike tests for eliminating positional nystagmus: A multicenter randomized study Open
Background and objectives Patients with benign paroxysmal positional vertigo of the posterior canal (pc-BPPV) exhibit BPPV fatigue, where the positional nystagmus diminishes with the repeated performance of the Dix–Hallpike test (DHt). BPP…
View article: A Case of Cervical Gas Gangrene with Intractable Residual Pharyngeal Fistula That Was Closed Using a PGA Sheet
A Case of Cervical Gas Gangrene with Intractable Residual Pharyngeal Fistula That Was Closed Using a PGA Sheet Open
Gas gangrene is a progressive necrotizing soft tissue infection caused by bacteria. Cervical gas gangrene carries a poor prognosis, because of the risk of vital complications such as sepsis, disseminated intravascular coagulation, and desc…
View article: Outpatient ablation treatment with two doses of 30 mCi of radioactive iodine for non-low-risk papillary thyroid cancer
Outpatient ablation treatment with two doses of 30 mCi of radioactive iodine for non-low-risk papillary thyroid cancer Open
Outpatient ablation therapy with low-dose radioactive iodine (RAI) is applied to non-low-risk papillary thyroid cancer patients due to a chronic shortage of inpatient RAI treatment wards in Japan. We used the maximum dosage available for o…
View article: Risk factors of first bite syndrome after surgical resection of parapharyngeal space tumors
Risk factors of first bite syndrome after surgical resection of parapharyngeal space tumors Open
The present findings suggest that concomitant surgical settings of 1) sympathetic denervation of the parotid gland with ligation of the external carotid artery or injury of the sympathetic nerve plexus around the external carotid artery du…
View article: Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia
Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia Open
Propolis, a resinous substance produced by honeybees, has been used in folk medicine since ancient times due to its many biological benefits such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects. Pr…
View article: Efficacy of dual sublingual immunotherapy with Japanese cedar pollen and house dust mite allergens in patients with allergic rhinitis sensitized to multiple allergens
Efficacy of dual sublingual immunotherapy with Japanese cedar pollen and house dust mite allergens in patients with allergic rhinitis sensitized to multiple allergens Open
Objective In the present study, we examined the effects of dual sublingual immunotherapy (SLIT) with Japanese cedar pollen (JCP) and house dust mite (HDM) allergens on nasal symptoms during the peak pollen period (PPP) and in late fall (LF…
View article: A Novel Method of Assessment of the Zinc Nutrition Status and Zinc Deficiency-Induced Taste Impairment
A Novel Method of Assessment of the Zinc Nutrition Status and Zinc Deficiency-Induced Taste Impairment Open
We developed the ratio of the apo/holo activities of angiotensin-converting enzyme (ACE ratio) in the serum as an index of the zinc nutrition status. The zinc nutrition status in patients with taste impairment was estimated based on the di…
View article: Effects of sublingual immunotherapy with tablets or drops containing Japanese cedar pollen antigens on nasal symptoms and sleep disturbance in patients with Japanese cedar pollinosis
Effects of sublingual immunotherapy with tablets or drops containing Japanese cedar pollen antigens on nasal symptoms and sleep disturbance in patients with Japanese cedar pollinosis Open
It is suggested that SLIT with JCP tablets improved both nasal symptoms and sleep disturbances at peak pollen period in patients with Japanese cedar pollinosis. SLIT with JCP tablets for one year was more effective than SLIT with JCP drops…
View article: Auricular Stimulation with Capsaicin Ointment as Prophylaxis Against Aspiration Pneumonia
Auricular Stimulation with Capsaicin Ointment as Prophylaxis Against Aspiration Pneumonia Open
Dysphagia increases the risk of aspiration pneumonia. Cough reflex plays an important role in protecting the respiratory tract against inhalation of foreign particles. However, the sensitivity of the cough reflex is reduced in elderly subj…
View article: Development of a Phototherapy Device for Allergic Rhinitis Using LEDs Emitting Narrowband UVB
Development of a Phototherapy Device for Allergic Rhinitis Using LEDs Emitting Narrowband UVB Open
Narrowband ultraviolet B (NB-UVB) phototherapy has been used clinically for the treatment of atopic dermatitis (AD). Therefore, NB-UVB phototherapy could also be effective for the treatment of allergic rhinitis (AR), because AR is also a T…
View article: Clinical Statistics of Patients with Dizziness and Vertigo at Tokushima University Hospital
Clinical Statistics of Patients with Dizziness and Vertigo at Tokushima University Hospital Open
In the present study, we enrolled a total of 506 patients who visited the Department of Otolaryngology Head Neck Surgery, Tokushima University Hospital, complaining of vertigo or dizziness between January 2017 and December 2020. Patients w…
View article: Clinical Outcomes of Treatment for Tongue Cancer at Tokushima University Hospital
Clinical Outcomes of Treatment for Tongue Cancer at Tokushima University Hospital Open
In the present retrospective study, a total of 42 patients with tongue cancer who had received their primary treatment at the Department of Otolaryngology Head and Neck Surgery, Tokushima University Hospital, between January 2010 and Decem…
View article: Pathophysiology of Benign Paroxysmal Positional Vertigo
Pathophysiology of Benign Paroxysmal Positional Vertigo Open
Benign paroxysmal positional vertigo (BPPV) caused by a peripheral vestibular lesion is the most commonly encountered type of vertigo in clinical practice. BPPV has been classified according to the canal of origin, as posterior canal BPPV,…
View article: Role of α-Fodrin Autoantigen in Sjögren’s Syndrome
Role of α-Fodrin Autoantigen in Sjögren’s Syndrome Open
The α-Fodrin N-terminal portion (AFN) autoantigen is involved in T cell-medicated autoimmune responses in patients with Sjögren’s syndrome. The infiltration of autoreactive T cells and the cleavage products of AFN were found in the salivar…
View article: Development of New Vestibular Rehabilitation Methods Using Devices for Patients with Refractory Dizziness
Development of New Vestibular Rehabilitation Methods Using Devices for Patients with Refractory Dizziness Open
Vestibular rehabilitation is effective for providing relief from dizziness and improving imbalance in uncompensated patients with unilateral vestibulopathy. However, some patients are refractory to conventional vestibular rehabilitation. W…
View article: Early Identification of Children with Speech and Language Disorders by Advanced Infant Health Examinations and School Medical Checkups
Early Identification of Children with Speech and Language Disorders by Advanced Infant Health Examinations and School Medical Checkups Open
In Japan, infant health examinations and school medical checkups are well established and are useful for early identification of speech and language disorders in children. In Tokushima, we have well-developed advanced infant health examina…
View article: Defensive Role of Viral-Specific Nasal Secretory IgA Antibody Against Influenza Infection in Adults: Translational Research in the Development of Intranasal Vaccines
Defensive Role of Viral-Specific Nasal Secretory IgA Antibody Against Influenza Infection in Adults: Translational Research in the Development of Intranasal Vaccines Open
In order to clarify human mucosal and systemic immunity against influenza viral infection, we measured the anti-influenza viral-specific secretory IgA (s-IgA) titers in the nasal secretions and IgG titers in the serum of adults. We used a …
View article: Bernoulli Effect Producing Maneuver-Induced Pharyngeal Narrowing in Patients with Obstructive Sleep Apnea Syndrome
Bernoulli Effect Producing Maneuver-Induced Pharyngeal Narrowing in Patients with Obstructive Sleep Apnea Syndrome Open
We developed a new method to evaluate dynamic narrowing of the pharynx induced by the Bernoulli effect producing maneuver (BEPM) of forced inspiration through the nose with the mouth closed in patients with obstructive sleep apnea syndrome…
View article: Spatial Disorientation and Its Implication of Vertigo and Vertigo-Induced Vomiting
Spatial Disorientation and Its Implication of Vertigo and Vertigo-Induced Vomiting Open
Histamine H1 receptors are involved in the development of the symptoms and signs of motion sickness and vertigo-induced vomiting. In the development of motion sickness and vertigo-induced vomiting, a neural mismatch signal encoding spatial…
View article: Recent Advances in the Management and Clinical Outcomes of Treatment for Allergic Rhinitis at Tokushima University Hospital
Recent Advances in the Management and Clinical Outcomes of Treatment for Allergic Rhinitis at Tokushima University Hospital Open
Japanese cedar (JC) pollinosis is the most common form of allergic rhinitis (AR) in Japan, and its prevalence is only increasing. Now, more than one-third of Japanese people are estimated to suffer from JC pollinosis. Recently, sublingual …
View article: Molecular Mechanisms of Transcriptional Upregulation of the Histamine H<sub>1</sub> Receptor Gene in the Development of Allergic Rhinitis
Molecular Mechanisms of Transcriptional Upregulation of the Histamine H<sub>1</sub> Receptor Gene in the Development of Allergic Rhinitis Open
Histamine is a major chemical mediator involved in the development of allergic rhinitis, inducing the symptoms of allergic rhinitis through binding to the histamine H1 receptor (H1R). H1R is a rate-limiting molecule in histamine signaling,…