Naoya Wada
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View article: SARS-CoV-2 Main Protease Inhibitors Containing 5-Substituted Benzothiazole-2-carbonyl Moieties at the P1′ Site and Their Derivatives
SARS-CoV-2 Main Protease Inhibitors Containing 5-Substituted Benzothiazole-2-carbonyl Moieties at the P1′ Site and Their Derivatives Open
Development of anti-SARS-CoV-2 agents is still required because of the appearance of drug-resistant strains, and targeting the main protease (Mpro) of SARS-CoV-2 is a powerful way to develop therapeutics against COVID-19. To date, we have …
View article: Compact-size and high mode-scalability spatial-mode multiplexer using multiplexed volume holograms
Compact-size and high mode-scalability spatial-mode multiplexer using multiplexed volume holograms Open
A spatial mode multiplexer that uses multiplexed volume holograms provides a compact and high mode-scalability solution for multiplexing spatial modes in mode division multiplexing (MDM) transmission. In this approach, multiplexed volume h…
View article: Effects of β-Cryptoxanthin on Cisplatin-Treated Human Oral Mucosa-Derived Keratinocytes and Fibroblasts
Effects of β-Cryptoxanthin on Cisplatin-Treated Human Oral Mucosa-Derived Keratinocytes and Fibroblasts Open
Cisplatin (CDDP) is an anticancer drug that is frequently used to treat head and neck cancers; however, it may cause oral mucositis. The discontinuation of CDDP may be required for some patients with a severe status, and the control of ora…
View article: Time stretch with continuous-wave lasers
Time stretch with continuous-wave lasers Open
Ultrafast single-shot measurement techniques with high throughput are needed for capturing rare events that occur over short time scales. Such instruments unveil non-repetitive dynamics in complex systems and enable new types of spectromet…
View article: Anode Properties of Sb-Based Alloy Electrodes for K-Ion Batteries in an Ionic-Liquid Electrolyte
Anode Properties of Sb-Based Alloy Electrodes for K-Ion Batteries in an Ionic-Liquid Electrolyte Open
Maintaining the sustainability of society demands the strategic use of multipurpose rechargeable batteries. One promising option is K-ion batteries (KIBs), which are suitable as large stationary storage batteries and store renewable energy…
View article: Structure–Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties
Structure–Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties Open
The main protease (Mpro) of SARS-CoV-2 is an attractive target for the development of drugs to treat COVID-19. Here, we report the design, synthesis, and structure-activity relationship (SAR) studies of highly potent SARS-CoV-2 Mpro inhibi…
View article: Time Stretch with Continuous-Wave Lasers
Time Stretch with Continuous-Wave Lasers Open
A single-shot measurement technique for ultrafast phenomena with high throughput enables the capture of rare events within a short time scale, facilitating the exploration of rare ultrafast processes. Photonic time stretch stands out as a …
View article: Effects of low‐frequency outpatient pulmonary rehabilitation in preventing COPD exacerbations
Effects of low‐frequency outpatient pulmonary rehabilitation in preventing COPD exacerbations Open
【目的】慢性閉塞性肺疾患(以下,COPD)において,増悪予防は重要な疾病管理目標である.COPD増悪予防には呼吸リハビリテーションが推奨されているが,社会的背景などにより頻回な外来呼吸リハビリテーションが困難な実情がある.本研究では低頻度外来呼吸リハビリテーションのCOPD増悪予防効果を検証することとした.
View article: Potent and biostable inhibitors of the main protease of SARS-CoV-2
Potent and biostable inhibitors of the main protease of SARS-CoV-2 Open
Potent and biostable inhibitors of the main protease (Mpro) of SARS-CoV-2 were designed and synthesized based on an active hit compound 5h (2). Our strategy was based not only on the introduction of fluorine atoms into the inhibitor molecu…
View article: Performances of Conventional SOAs Versus QD-SOA in 1530-nm Upstream Transmission of 40 Gb/s Access Network
Performances of Conventional SOAs Versus QD-SOA in 1530-nm Upstream Transmission of 40 Gb/s Access Network Open
SOA is the key device for burst-mode upstream transmission of 40 Gb/s access network to extend distance and increase users. We evaluate two conventional SOAs and our QD-SOA in networks, consisting of 20-km Single Mode Fiber (SMF) and split…
View article: In-process measurement of a keyhole using a low-coherence interferometer with a high repetition rate
In-process measurement of a keyhole using a low-coherence interferometer with a high repetition rate Open
The shape of an instance hole (keyhole) created via a high-power laser was measured using a low-coherence interferometer with the following parameters: repetition rate, 10 MHz; center wavelength, 1550 nm; absolute spatial resolution, 10 µm…
View article: Effects of exercise during dialysis therapy on physical motor function and quality of life
Effects of exercise during dialysis therapy on physical motor function and quality of life Open
血液透析患者20例に対し透析中の運動療法を6か月間施行した．身体運動機能，栄養評価を介入前，3，6か月後に行い，統計解析はHolmの多重比較検定を用いた．Quality of life（QOL）は介入前後に評価し，Wilcoxon符号付順位和検定を用い比較した．いずれもp＜0.05を有意差ありと判定した．身体運動機能は介入3か月後に握力（非シャント肢），膝伸展筋力，足趾把持力，外転筋力，30秒立ち上がり試験，6分間歩行が向上し6か月後も維持または向上した．血中ヘモグロビン濃…
View article: High Capacity Converged Passive Optical Network and RoF-Based 5G+ Fronthaul Using 4-PAM and NOMA-CAP Signals
High Capacity Converged Passive Optical Network and RoF-Based 5G+ Fronthaul Using 4-PAM and NOMA-CAP Signals Open
© 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, cre…
View article: Impulse Response Measurement of Spooled and Twisted Few-Mode Multi-Core Fiber for Short-Range Optical Links
Impulse Response Measurement of Spooled and Twisted Few-Mode Multi-Core Fiber for Short-Range Optical Links Open
The impact of bending and twisting on the impulse response matrix is investigated using optical vector network analysis. The heterogeneous 36-core 3-mode fiber under test is spooled at bending radii of 8 cm to 50 cm and additionally up to …
View article: Experimental emulation of nonlinear distortion suppression by FrOFDM subcarriers
Experimental emulation of nonlinear distortion suppression by FrOFDM subcarriers Open
Fractional orthogonal frequency division multiplexing (FrOFDM) exhibits considerable flexibility in the axis of multiplexing and a medium characteristic between OFDM and Nyquist optical time division multiplexing. FrOFDM subcarrier effect …
View article: Optical Power Budget Enhancement in 50–90 Gb/s IM-DD PONs With NOMA-CAP and SOA-Based Amplification
Optical Power Budget Enhancement in 50–90 Gb/s IM-DD PONs With NOMA-CAP and SOA-Based Amplification Open
We report experimental results of a semiconductor optical amplifier (SOA) for optical amplification in a 50-90 Gb/s IM-DD optical access system using non-orthogonal multiple access multiplexing combined with multi-band carrierless amplitud…
View article: Low-coherence interferometer with 10 MHz repetition rate and compensation of nonlinear chromatic dispersion
Low-coherence interferometer with 10 MHz repetition rate and compensation of nonlinear chromatic dispersion Open
We developed a low-coherence interference measurement system using the time-stretch dispersive Fourier transformation technique and demonstrated 10 MHz measurements of the interference signal. We estimated the path length distribution by p…
View article: Characterization and Optical Compensation of LP01 and LP11 Intra-modal Nonlinearity in Few-Mode Fibers
Characterization and Optical Compensation of LP01 and LP11 Intra-modal Nonlinearity in Few-Mode Fibers Open
Intra-modal four-wave mixing (FWM) and all-optical compensation by optical phase conjugation is investigated over 2-spans of 3-mode fiber with the power of the generated FWM products reduced by 5 to 20 dB in different scenarios.
View article: Experimental Demonstration of Optical Multicast Packet Transmissions in Optical Packet/Circuit Integrated Networks
Experimental Demonstration of Optical Multicast Packet Transmissions in Optical Packet/Circuit Integrated Networks Open
We develop an SDN-based control for optical-multicast packet transmission and experimentally demonstrate multicast functionality by validating it using an application-layer network service for efficient content duplication in Optical Packe…
View article: Polarization Equalization in Optical Vector Network Analysis for SDM Fiber Characterization
Polarization Equalization in Optical Vector Network Analysis for SDM Fiber Characterization Open
Precise characterization of space division multiplexing fibers is a key requirement for their further development and deployment in the field. Optical vector network analysis allows to measure all linear parameters of such fibers in a sing…
View article: Master-slave carrier recovery for M-QAM multicore fiber transmission
Master-slave carrier recovery for M-QAM multicore fiber transmission Open
Master-slave carrier recovery is a digital signal processing technique that uses correlated phase noise in multi-channel receivers to eliminate redundant carrier recovery blocks. In this paper we experimentally investigate the performance …
View article: Corrections to “High Capacity Transmission With Few-Mode Fibers”
Corrections to “High Capacity Transmission With Few-Mode Fibers” Open
Presents corrections to the paper, “High capacity transmission with few-mode fibers,” (Rademacher, G.), Lightw. Technol., vol. 37, no. 2, pp. 425–432, Jan. 2019.
View article: Enhanced Modal Dispersion Estimation Enabled by Chromatic Dispersion Compensation in Optical Vector Network Analysis
Enhanced Modal Dispersion Estimation Enabled by Chromatic Dispersion Compensation in Optical Vector Network Analysis Open
Component characterization is fundamental for understanding the limits of optical devices, sub-systems, and transmission systems. With the introduction of space division multiplexing in optical fiber transmission systems, new impairments, …
View article: Demonstration of PAM4-OCDM system with electrical amplitude-level pre-tuning and post-equalization for data centers applications
Demonstration of PAM4-OCDM system with electrical amplitude-level pre-tuning and post-equalization for data centers applications Open
A PAM4-OCDM system with optical multi-/demultiplexing and electrical pre-/post-processing is proposed for short-reach applications. We experimentally demonstrate, for the first time, a power-efficient 4 OC x 10 GSymbol/s PAM4-OCDM system. …
View article: Wavelength division multiplexing of continuous variable quantum key distribution and 18.3 Tbit/s data channels
Wavelength division multiplexing of continuous variable quantum key distribution and 18.3 Tbit/s data channels Open
Quantum key distribution (QKD) can offer communication with unconditional security and is a promising technology to protect next generation communication systems. For QKD to see commercial success, several key challenges have to be solved,…
View article: Inter-Core Crosstalk Impact of Classical Channels on CV-QKD in Multicore Fiber Transmission
Inter-Core Crosstalk Impact of Classical Channels on CV-QKD in Multicore Fiber Transmission Open
Crosstalk-induced excess noise is experimentally characterized for continuous-variable quantum key distribution, spatially multiplexed with WDM PM-16QAM channels in a 19-core fiber. The measured noise-sources are used to estimate the secre…
View article: Chromatic Dispersion Analysis and Compensation in a Large Core-Count Few-Mode Multi-Core Fiber Based on Optical Vector Network Analysis
Chromatic Dispersion Analysis and Compensation in a Large Core-Count Few-Mode Multi-Core Fiber Based on Optical Vector Network Analysis Open
Chromatic dispersion in a large core-count 3-mode fiber is analyzed, observing up to 0.75 ps/(nm km) variations between mode groups. Furthermore, digital CD compensation is shown to relax the stringent path length matching required in such…