Timothy N. C. Wells
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View article: Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with <i>Plasmodium falciparum</i>
Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with <i>Plasmodium falciparum</i> Open
Inhibiting the inflammatory response to malaria offers a promising strategy to improve clinical outcomes and overcome immunoregulatory barriers that hinder development of antiparasitic immunity. We conducted a double-blind, randomized, pla…
View article: Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV-2 Papain-like Protease (PL<sup>pro</sup>) Inhibitors
Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV-2 Papain-like Protease (PL<sup>pro</sup>) Inhibitors Open
The COVID-19 pandemic, caused by SARS-CoV-2, has led to more than 760 million infections and 6.9 million deaths worldwide. While vaccines have played a crucial role in controlling the disease, emerging viral variants pose a threat to their…
View article: Adjunctive ruxolitinib attenuates inflammation and enhances antiparasitic immunity in human volunteers experimentally infected with<i>Plasmodium falciparum</i>
Adjunctive ruxolitinib attenuates inflammation and enhances antiparasitic immunity in human volunteers experimentally infected with<i>Plasmodium falciparum</i> Open
Inhibiting the host inflammatory response to malaria represents a potential strategy to improve clinical outcomes and inhibit immunoregulatory pathways that underlie suboptimal development of antiparasitic immunity. Ruxolitinib is a JAK 1/…
View article: Chemoprevention of malaria with long-acting oral and injectable drugs: an updated target product profile
Chemoprevention of malaria with long-acting oral and injectable drugs: an updated target product profile Open
Malaria is preventable, but the burden of disease remains high with over 249 million cases and 608,000 deaths reported in 2022. Historically, the most important protective interventions have been vector control and chemopreventive medicine…
View article: PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies
PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies Open
The urgent need for safe, efficacious, and accessible drug treatments to treat coronavirus disease 2019 (COVID‐19) prompted a global effort to evaluate drug repurposing opportunities. Pyronaridine and amodiaquine are both components of app…
View article: A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity
A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity Open
Background Infection with parasitic nematodes (helminths), particularly those of the order Strongylida (such as Haemonchus contortus ), can cause significant and burdensome diseases in humans and animals. Widespread drug (anthelmintic) res…
View article: Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans
Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans Open
Global challenges with treatment failures and/or widespread resistance in parasitic worms against commercially available anthelmintics lend impetus to the development of new anthelmintics with novel mechanism(s) of action. The free-living …
View article: Bacpath 16
Bacpath 16 Open
This year, the 16th ASM Bacterial Pathogens (Bacpath) conference was held in Brisbane between 27 and 30 September 2022 using venues located at the University of Queensland and the Emporium Hotel near South Bank Parklands.After a year's del…
View article: Crowdsourcing/Winter Operations Dashboard Upgrade
Crowdsourcing/Winter Operations Dashboard Upgrade Open
INDOT has recently completed the deployment of Parsons telematics-based dash-cameras, automatic vehicle locator (AVL) positions, and spreader rate monitoring across their winter operations fleet. The motivation of this study was to develop…
View article: The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication
The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication Open
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever, a disabling disease that can cause long-term severe arthritis. Since the last large CHIKV outbreak in 2015, the reemergence of the virus represents a serious public hea…
View article: The Pandemic Response Box─Accelerating Drug Discovery Efforts after Disease Outbreaks
The Pandemic Response Box─Accelerating Drug Discovery Efforts after Disease Outbreaks Open
The current Covid-19 pandemic has underlined the need for a more coordinated and forward-looking investment in the search for new medicines targeting emerging health care threats. Repositioning currently approved drugs is a popular approac…
View article: Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in <i>Mycobacterium abscessus</i>
Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in <i>Mycobacterium abscessus</i> Open
A search for alternative Mycobacterium abscessus treatments led to our interest in the two-component regulator DosRS, which, in Mycobacterium tuberculosis , is required for the bacterium to establish a state of nonreplicating, drug-toleran…
View article: A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity
A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity Open
Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus contortus, are particularly important. The excessive use of …
View article: Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium <i>in vitro</i>
Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium <i>in vitro</i> Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in late 2019, has caused a worldwide pandemic with unprecedented economic and societal impact. Currently, several vaccines are available, and multitudes of …
View article: Intelligent Sidewalk De-icing and Pre-treatment with Connected Campus Maintenance Vehicles
Intelligent Sidewalk De-icing and Pre-treatment with Connected Campus Maintenance Vehicles Open
Salt brine is routinely used by transportation agencies to pre-treat critical infrastructure such as bridges, ramps, and underpasses in advance of winter storms.Traditional manual techniques of the operator turning on and off the brine con…
View article: A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria Open
Background For uncomplicated Plasmodium falciparum malaria, highly efficacious single-dose treatments are expected to increase compliance and improve treatment outcomes, and thereby may slow the development of resistance. The efficacy and …
View article: Development of an Intelligent Snowplow Truck that Integrates Telematics Technology, Roadway Sensors, and Connected Vehicle
Development of an Intelligent Snowplow Truck that Integrates Telematics Technology, Roadway Sensors, and Connected Vehicle Open
The Indiana Department of Transportation (INDOT) manages and maintains over 28,000 miles of roadways. Maintenance of the roadways includes pavement repair in the summer as well as snow removal and de-icing in the winter. The prioritization…
View article: Identification of Chlorophyll a-b Binding Protein AB96 as a novel TGFβ1 binding agent
Identification of Chlorophyll a-b Binding Protein AB96 as a novel TGFβ1 binding agent Open
The discovery of compounds and proteins from plants has greatly contributed to modern medicine, especially in malaria where both quinine and artemisinin have been the cornerstone of therapeutics. Here we describe the first known plant-deri…
Reassessing therapeutic antibodies for neglected and tropical diseases Open
In the past two decades there has been a significant expansion in the number of new therapeutic monoclonal antibodies (mAbs) that are approved by regulators. The discovery of these new medicines has been driven primarily by new approaches …
View article: A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria
A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria Open
Reaching the overall goal of eliminating malaria requires halting disease transmission. One approach to blocking transmission is to prevent passage of the parasite to a mosquito, by preventing formation or transmission of gametocytes. An a…
View article: High proportion of multiple copies of <i>Plasmodium falciparum Plasmepsin-2</i> gene in African isolates: Is piperaquine resistance emerging in Africa?
High proportion of multiple copies of <i>Plasmodium falciparum Plasmepsin-2</i> gene in African isolates: Is piperaquine resistance emerging in Africa? Open
Emergence of Plasmodium falciparum resistance to antimalarial drugs is currently the primary rationale supporting the development of new and well-tolerated drugs. In 2014-2015, a phase 2b clinical study was conducted to evaluate the effica…