N. Zwart
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View article: Folate‐Associated DNA Methylation and Chemotherapy‐Induced Toxicities in Patients With Colorectal Cancer
Folate‐Associated DNA Methylation and Chemotherapy‐Induced Toxicities in Patients With Colorectal Cancer Open
Patients with stage II‐III colorectal cancer (CRC) often receive fluoropyrimidine‐based chemotherapy, usually combined with other regimens, of which ∼50% experience severe chemotherapy‐induced toxicities. The B‐vitamin folate has been asso…
View article: Vitamin B6 status and chronic chemotherapy-induced peripheral neuropathy: a prospective cohort study among patients with non-metastatic colorectal cancer receiving oxaliplatin-based chemotherapy
Vitamin B6 status and chronic chemotherapy-induced peripheral neuropathy: a prospective cohort study among patients with non-metastatic colorectal cancer receiving oxaliplatin-based chemotherapy Open
Objective Chronic chemotherapy-induced peripheral neuropathy (CIPN) is a long-lasting side-effect of oxaliplatin. Vitamin B6 might play a role in the pathogenesis of CIPN. Therefore, we investigated associations between plasma vitamin B6 m…
View article: Folate, folic acid, and chemotherapy-induced toxicities: A systematic literature review
Folate, folic acid, and chemotherapy-induced toxicities: A systematic literature review Open
Folate metabolism is a target for various chemotherapeutic drugs. Folate and its synthetic variant folic acid are B-vitamins. To what extent these vitamins impact treatment tolerance in patients with cancer remains unclear. A systematic li…