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View article: Artificial intelligence in electrocardiogram signals for sudden cardiac death prediction: a systematic review and meta-analysis
Artificial intelligence in electrocardiogram signals for sudden cardiac death prediction: a systematic review and meta-analysis Open
This meta-analysis indicates that AI-based ECG analysis shows potential for SCD prediction. However, the summary estimates are derived from highly heterogeneous studies and should not be considered benchmarks for clinical performance. The …
View article: Acupuncture as an adjunctive therapy on embryo transfer day: a systematic review and meta-analysis of clinical pregnancy and live birth outcomes
Acupuncture as an adjunctive therapy on embryo transfer day: a systematic review and meta-analysis of clinical pregnancy and live birth outcomes Open
Background Acupuncture is frequently employed during the process of embryo transfer. Nevertheless, its precise function in enhancing the likelihood of successful clinical pregnancy or live birth remains ambiguous. Objective To evaluate the…
View article: A narrative review on the role of traditional Chinese medicine (TCM) in treating coronary artery disease
A narrative review on the role of traditional Chinese medicine (TCM) in treating coronary artery disease Open
Coronary artery disease is one of the leading types of cardiovascular disorders globally, and is a significant contributor to mortality. Its prevalence is increasing annually, underscoring the need for innovative therapeutic strategies to …
View article: Esketamine ameliorates post-stroke anxiety by modulating microglial HDAC3/NF-κB/COX1 inflammatory signaling in ischemic cortex
Esketamine ameliorates post-stroke anxiety by modulating microglial HDAC3/NF-κB/COX1 inflammatory signaling in ischemic cortex Open
Post-stroke anxiety (PSA) is a kind of affective disorder occurring after a stroke, with anxiety as the primary clinical manifestation. PSA's mechanism is unclear, and there are few prevention and treatment measures. Our previous study fou…
View article: Allometry of bud dynamic pattern and linkage between bud traits and ecological stoichiometry of <i>Nitraria tangutorum</i> under fertilizer addition
Allometry of bud dynamic pattern and linkage between bud traits and ecological stoichiometry of <i>Nitraria tangutorum</i> under fertilizer addition Open
Affected by the pressure and constraints of available resources, plant growth and development, as well as plant life history strategies, usually vary with environmental conditions. Plant buds play a crucial role in the life history of wood…
View article: Transcriptome Profiling and Chlorophyll Metabolic Pathway Analysis Reveal the Response of Nitraria tangutorum to Increased Nitrogen
Transcriptome Profiling and Chlorophyll Metabolic Pathway Analysis Reveal the Response of Nitraria tangutorum to Increased Nitrogen Open
To identify genes that respond to increased nitrogen and assess the involvement of the chlorophyll metabolic pathway and associated regulatory mechanisms in these responses, Nitraria tangutorum seedlings were subjected to four nitrogen con…
View article: Design and implementation of a smart Internet of Things chest pain center based on deep learning
Design and implementation of a smart Internet of Things chest pain center based on deep learning Open
The data input process for most chest pain centers is not intelligent, requiring a lot of staff to manually input patient information. This leads to problems such as long processing times, high potential for errors, an inability to access …
View article: Comparative and phylogenetic analysis based on chloroplast genome of Heteroplexis (Compositae), a protected rare genus
Comparative and phylogenetic analysis based on chloroplast genome of Heteroplexis (Compositae), a protected rare genus Open
Background Heteroplexis Chang is an endangered genus endemic to China with important ecological and medicinal value. However, due to the lack of genetic data, our conservation strategies have repeatedly been delayed by controversial phylog…
View article: WITHDRAWN: Ketamine alleviated blood-brain barrier damage and microglia over-activation induced by SIRS via restricting cecum damage and HMGB1 release
WITHDRAWN: Ketamine alleviated blood-brain barrier damage and microglia over-activation induced by SIRS via restricting cecum damage and HMGB1 release Open
Following systemic inflammatory response syndrome (SIRS), the brain is one of the most sensitive organs vulnerable to an external stressor. According to our previous study, ketamine had a protective effect on alleviating SIRS-associated ne…
View article: Cis-4-[18F]fluoro-L-proline PET/CT molecular imaging quantifying liver collagenogenesis: No existing fibrotic deposition in experimental advanced-stage alcoholic liver fibrosis
Cis-4-[18F]fluoro-L-proline PET/CT molecular imaging quantifying liver collagenogenesis: No existing fibrotic deposition in experimental advanced-stage alcoholic liver fibrosis Open
Background and purpose Heavy alcohol drinking-induced alcoholic fatty liver, steatohepatitis, and early-stage alcoholic liver fibrosis may progress to advanced-stage alcoholic liver fibrosis (AALF)/cirrhosis. The lack of non-invasive imagi…
View article: Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis
Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis Open
Stress is well known to contribute to the development of both neurological and psychiatric diseases. In the central nervous system, a role for STING (stimulator of interferon genes) in modulating immunological responses has been widely sug…
View article: Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial
Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial Open
Objective. To systematically assess the clinical efficacy of the Jie Yu Wan (JYW) formula in treating generalized anxiety disorder (GAD). Methods. A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) wa…
View article: Metabolic Pathways Involved in the Drought Stress Response of Nitraria tangutorum as Revealed by Transcriptome Analysis
Metabolic Pathways Involved in the Drought Stress Response of Nitraria tangutorum as Revealed by Transcriptome Analysis Open
Drought resistance in plants is controlled by multiple genes. To identify the genes that mediate drought stress responses and to assess the associated metabolic pathways in the desert shrub Nitraria tangutorum, we conducted a transcriptome…
View article: Genome Sequence of<i>Elaeagnus mollis</i>, the First Chromosome-Level Genome of the Family Elaeagnaceae
Genome Sequence of<i>Elaeagnus mollis</i>, the First Chromosome-Level Genome of the Family Elaeagnaceae Open
Elaeagnus mollis Diels (Elaeagnaceae) is a species of shrubs and/or dwarf trees that produces highly nutritious nuts with abundant oil and pharmaceutical properties. It is endemic to China but endangered. Therefore, to facilitate the prote…
View article: Development and novel design of clustery Graphene Oxide formed Conductive Silk hydrogel cell vesicle to Repair Myocardial Infarction: Investigation of its biological activity for cell delivery applications
Development and novel design of clustery Graphene Oxide formed Conductive Silk hydrogel cell vesicle to Repair Myocardial Infarction: Investigation of its biological activity for cell delivery applications Open
Cell delivery therapy is a talented and hopeful strategic approach to repair the damaged cardiac tissues after myocardial infarction. The biocompatible injectable hydrogel with bioactive nanomaterials with effective self-healing capability…
View article: From Patient-Controlled Analgesia to Artificial Intelligence-Assisted Patient-Controlled Analgesia: Practices and Perspectives
From Patient-Controlled Analgesia to Artificial Intelligence-Assisted Patient-Controlled Analgesia: Practices and Perspectives Open
Pain relief is a major concern for patients who have undergone surgery, and it is an eternal pursuit for anesthesiologists. However, postoperative pain management is far from satisfactory, though the past decades have witnessed great progr…
View article: Therapeutic Effect of Common Goldenrop Decoction Combined With Ramuli Cinnamomi Decoction in the Treatment of Patients with Insomnia during the Period of the Day from 11 PM to 3 AM
Therapeutic Effect of Common Goldenrop Decoction Combined With Ramuli Cinnamomi Decoction in the Treatment of Patients with Insomnia during the Period of the Day from 11 PM to 3 AM Open
Objective: To observe the clinical efficacy of common goldenrop decoction combined with ramuli cinnamomi decoction in the treatment of patients with insomnia during the period of the day from 11 PM to 3 AM. Methods: 80 patients with insomn…
View article: Computational insights into the binding pattern of mitochondrial calcium uniporter inhibitor through homology modeling, molecular dynamics simulation, binding free energy prediction and density functional theory calculation
Computational insights into the binding pattern of mitochondrial calcium uniporter inhibitor through homology modeling, molecular dynamics simulation, binding free energy prediction and density functional theory calculation Open
The mitochondrial calcium uniporter (MCU) is the critical protein of the inner mitochondrial membrane that is the primary mediator for calcium uptake into the mitochondrial matrix. Herein we built the optimal homology model of human MCU wh…
View article: <p>Pancreatic Ductal Adenocarcinoma: Machine Learning–Based Quantitative Computed Tomography Texture Analysis For Prediction Of Histopathological Grade</p>
Pancreatic Ductal Adenocarcinoma: Machine Learning–Based Quantitative Computed Tomography Texture Analysis For Prediction Of Histopathological Grade Open
Machine learning-based CT texture analysis accurately predicted histopathological differentiation grade of PDAC based on preoperative texture features, leading to maximization patient survival and achievement of personalized precision trea…
View article: Complete chloroplast genome sequence of <i>Hopea chinensis</i> (Dipterocarpaceae), a rare and critically endangered species
Complete chloroplast genome sequence of <i>Hopea chinensis</i> (Dipterocarpaceae), a rare and critically endangered species Open
Hopea chinensis (Dipterocarpaceae) is a rare and critically endangered species. Here, we first report and characterize its complete chloroplast genome sequence based on Illumina paired-end sequencing data. The complete plastid genome was 1…
View article: Complete chloroplast genome sequence of <i>Semiliquidambar cathayensis</i> (hamamelidaceae), a rare and endangered species endemic to China
Complete chloroplast genome sequence of <i>Semiliquidambar cathayensis</i> (hamamelidaceae), a rare and endangered species endemic to China Open
Semiliquidambar cathayensis (Hamamelidaceae) is a rare and endangered species endemic to China. Here, we first report and characterize the complete chloroplast genome sequence of S. cathayensis based on Illumina paired-end sequencing data.…
View article: Complete chloroplast genome sequence of <i>Annamocarya sinensis</i> (Juglandaceae), an endangered perennial plant
Complete chloroplast genome sequence of <i>Annamocarya sinensis</i> (Juglandaceae), an endangered perennial plant Open
Annamocarya sinensis (Juglandaceae) is a tertiary relict tree restricted to southeastern China and northern Vietnam. Here, we first report and characterize its complete chloroplast genome based on Illumina paired-end sequencing data. The c…
View article: Impact of IL-4 polymorphisms on head and neck cancer susceptibility in the Chinese Han population
Impact of IL-4 polymorphisms on head and neck cancer susceptibility in the Chinese Han population Open
Background: Head and neck cancer (HNC) is the sixth most frequent malignancy in the world.Interleukin 4 (IL-4) has been proved to be closely related to the occurrence and development of cancer.The objective of this research was to assess t…
View article: Impact of IL-4 polymorphisms on head and neck cancer susceptibility in the Chinese Han population
Impact of IL-4 polymorphisms on head and neck cancer susceptibility in the Chinese Han population Open
Background: Head and neck cancer (HNC) is the sixth most frequent malignancy in the world. Interleukin 4 (IL-4) has been proved to be closely related to the occurrence and development of cancer. The objective of this research was to assess…
View article: Complete chloroplast genome of <i>Euphorbia tirucalli</i> (Euphorbiaceae), a potential biofuel plant
Complete chloroplast genome of <i>Euphorbia tirucalli</i> (Euphorbiaceae), a potential biofuel plant Open
Euphorbia tirucalli is a highly drought-tolerant shrub with a potential as biofuel source, which has an important ecological and economic value. The complete chloroplast genome sequence of E. tirucalli was carried out using Illumina sequen…
View article: Complete chloroplast genome of <i>Caragana kozlowii</i>, an alpine shrub endemic to China
Complete chloroplast genome of <i>Caragana kozlowii</i>, an alpine shrub endemic to China Open
Endemic to the southeast boundary of Tibet plateau, the medicinal alpine shrub Caragana kozlowii is a threatened species. The genetic and molecular data about it is insufficient. In this paper, the complete chloroplast (cp) genome sequence…
View article: Complete chloroplast genome of <i>Euphorbia hainanensis</i> (Euphorbiaceae), a rare cliff top boskage endemic to China
Complete chloroplast genome of <i>Euphorbia hainanensis</i> (Euphorbiaceae), a rare cliff top boskage endemic to China Open
Euphorbia hainanensis is a rare cliff top boskage, which has an important ecological and economic value. In this study, we sequenced its complete chloroplast (cp) genome using Illumina sequencing platform. The cp genome of E. hainanensis i…