Nicola A. Hanania
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View article: Hyperglycemia, Receptor for Advanced Glycation End-Products, and Small Airways Dysfunction in Asthma
Hyperglycemia, Receptor for Advanced Glycation End-Products, and Small Airways Dysfunction in Asthma Open
View article: Comorbidities as treatable traits of chronic airway diseases
Comorbidities as treatable traits of chronic airway diseases Open
Chronic airway diseases, including asthma, chronic obstructive pulmonary disease, and bronchiectasis, are increasingly recognized as heterogeneous conditions influenced not only by airway pathology but also by a wide range of extrapulmonar…
View article: Established and Emerging Asthma Biomarkers with a Focus on Biologic Trials: A Narrative Review
Established and Emerging Asthma Biomarkers with a Focus on Biologic Trials: A Narrative Review Open
Chronic airway inflammation with variable airflow obstruction is clinical asthma, and it arises from distinct molecular and pathological mechanisms called endotypes. Biomarkers allow for precise endotype characterization and have been used…
View article: Type 2 inflammation biomarkers and their association with response to dupilumab in COPD (BOREAS): an analysis of a randomised, placebo-controlled, phase 3 trial
Type 2 inflammation biomarkers and their association with response to dupilumab in COPD (BOREAS): an analysis of a randomised, placebo-controlled, phase 3 trial Open
Sanofi and Regeneron Pharmaceuticals.
View article: Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort
Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort Open
Frailty is associated with respiratory exacerbations and mortality in individuals with Chronic Obstructive Pulmonary Disease (COPD). Among those with a smoking history and normal spirometry, frailty's association with respiratory outcomes …
View article: COVID-19, asthma, and biological therapies: What we need to know
COVID-19, asthma, and biological therapies: What we need to know Open
View article: Burden of Oral Corticosteroid Use in Severe Asthma: Challenges and Opportunities
Burden of Oral Corticosteroid Use in Severe Asthma: Challenges and Opportunities Open
Over the past 70 years, oral corticosteroids (OCS) have played an important role in the management of acute and chronic asthma; however, their use is associated with an increased incidence of adverse events, chronic diseases such as osteop…
View article: Comparative effectiveness of inhaled fluticasone propionate/salmeterol and budesonide/formoterol fixed-dose combinations in asthma control – a retrospective United States database analysis
Comparative effectiveness of inhaled fluticasone propionate/salmeterol and budesonide/formoterol fixed-dose combinations in asthma control – a retrospective United States database analysis Open
FP/SAL and BUD/FOR were similarly effective for asthma control in real-world settings, while FP/SAL was generally associated with greater medication adherence, a key factor for long-term control.
View article: A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease
A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease Open
Importance Individuals at risk for chronic obstructive pulmonary disease (COPD) but without spirometric airflow obstruction can have respiratory symptoms and structural lung disease on chest computed tomography. Current guidelines recommen…
View article: The Emerging Biomarkers in Chronic Obstructive Pulmonary Disease: A Narrative Review
The Emerging Biomarkers in Chronic Obstructive Pulmonary Disease: A Narrative Review Open
The burden of chronic obstructive pulmonary disease (COPD) is increasing, especially for women in low-to-middle income countries. Biomarkers provide ever-increasing diagnostic precision for COPD and show promise for primary, secondary, and…
View article: Asthma in the Biologics Era: Should Oral Corticosteroid Therapy Be Relegated to History?
Asthma in the Biologics Era: Should Oral Corticosteroid Therapy Be Relegated to History? Open
View article: Inflammatory and clinical risk factors for asthma attacks (ORACLE2): a patient-level meta-analysis of control groups of 22 randomised trials
Inflammatory and clinical risk factors for asthma attacks (ORACLE2): a patient-level meta-analysis of control groups of 22 randomised trials Open
View article: Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area
Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area Open
View article: The Direct and Indirect Role of IgE on Airway Epithelium in Asthma
The Direct and Indirect Role of IgE on Airway Epithelium in Asthma Open
Asthma is a chronic airway inflammatory disorder, affecting over 350 million people worldwide, with allergic asthma being the most common form of the disease. Allergic asthma is characterized by a type 2 (T2) inflammatory response triggere…
View article: Post-Hoc Analyses Support Efficacy of Lebrikizumab in Patients With Moderate-to-Severe Uncontrolled Eosinophilic Asthma and Prior Exacerbations
Post-Hoc Analyses Support Efficacy of Lebrikizumab in Patients With Moderate-to-Severe Uncontrolled Eosinophilic Asthma and Prior Exacerbations Open
Introduction: Lebrikizumab, a novel, high-affinity monoclonal antibody selectively targeting interleukin-13, has demonstrated efficacy and safety in moderate-to-severe atopic dermatitis at higher doses than studied in asthma. Clinical tria…
View article: Clinical Characteristics of Patients With COPD and Comorbid Depression and Anxiety: Data From a National Multicenter Cohort Study
Clinical Characteristics of Patients With COPD and Comorbid Depression and Anxiety: Data From a National Multicenter Cohort Study Open
View article: Dupilumab Improves Health-Related Quality of Life and Respiratory Symptoms in Patients With COPD and Type 2 Inflammation: BOREAS and NOTUS
Dupilumab Improves Health-Related Quality of Life and Respiratory Symptoms in Patients With COPD and Type 2 Inflammation: BOREAS and NOTUS Open
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View article: Pragmatic Evaluation of an Improvement Program for People Living With Modifiable High-Risk COPD Versus Usual Care: Protocol for the Cluster Randomized PREVAIL Trial
Pragmatic Evaluation of an Improvement Program for People Living With Modifiable High-Risk COPD Versus Usual Care: Protocol for the Cluster Randomized PREVAIL Trial Open
UK trial: ISRCTN15819828; US trial: NCT05306743.
View article: Practical strategies for achieving system change in the US: lessons and insights from the CONQUEST quality improvement programme
Practical strategies for achieving system change in the US: lessons and insights from the CONQUEST quality improvement programme Open
Background: Quality improvement programmes (QIPs) are designed to enhance patient outcomes by systematically introducing evidence-based clinical practices. The CONQUEST QIP focuses on improving the identification and management of patients…
View article: Phosphodiesterase Inhibition as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease: Where We Have Been and What Lies Ahead
Phosphodiesterase Inhibition as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease: Where We Have Been and What Lies Ahead Open
Chronic obstructive pulmonary disease (COPD) is a highly prevalent inflammatory lung condition characterized by chronic respiratory symptoms and airflow obstruction that often leads to diminished quality of life. Nonpharmacologic managemen…
View article: Promoting Prevention and Targeting Remission of Asthma
Promoting Prevention and Targeting Remission of Asthma Open
View article: Clinical Characteristics of Patients With COPD and Comorbid Depression and Anxiety: Data From a National Multicenter Cohort Study
Clinical Characteristics of Patients With COPD and Comorbid Depression and Anxiety: Data From a National Multicenter Cohort Study Open
Depression and anxiety disorders meeting diagnostic criteria are relatively common comorbidities that substantially impair quality of life and are undertreated, highlighting a need to prioritize mental health as an integral part of compreh…
View article: ASSOCIATION OF INSULIN RESISTANCE WITH RADIOGRAPHIC LUNG ABNORMALITIES AND INCIDENT LUNG DISEASE: THE FRAMINGHAM OFFSPRING STUDY
ASSOCIATION OF INSULIN RESISTANCE WITH RADIOGRAPHIC LUNG ABNORMALITIES AND INCIDENT LUNG DISEASE: THE FRAMINGHAM OFFSPRING STUDY Open
ObjectiveInsulin resistance (IR) may be a risk factor for lung disease, but objective evidence is limited. We sought to define the relationship of longitudinal IR to radiographic imaging outcomes and examiner-identified incident lung disea…
View article: ASSOCIATION OF INSULIN RESISTANCE WITH RADIOGRAPHIC LUNG ABNORMALITIES AND INCIDENT LUNG DISEASE: THE FRAMINGHAM OFFSPRING STUDY
ASSOCIATION OF INSULIN RESISTANCE WITH RADIOGRAPHIC LUNG ABNORMALITIES AND INCIDENT LUNG DISEASE: THE FRAMINGHAM OFFSPRING STUDY Open
ObjectiveInsulin resistance (IR) may be a risk factor for lung disease, but objective evidence is limited. We sought to define the relationship of longitudinal IR to radiographic imaging outcomes and examiner-identified incident lung disea…
View article: Dupilumab reduces exacerbations and improves lung function in patients with chronic obstructive pulmonary disease and emphysema: Phase 3 randomized trial (BOREAS)
Dupilumab reduces exacerbations and improves lung function in patients with chronic obstructive pulmonary disease and emphysema: Phase 3 randomized trial (BOREAS) Open
Dupilumab efficacy was similar in patients with COPD and type 2 inflammation, with or without investigator-reported emphysema.
View article: Personalized COPD Care: The Future of Precision-Based Therapies
Personalized COPD Care: The Future of Precision-Based Therapies Open
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory illness characterized by long-standing respiratory symptoms and airflow limitation. It is a major contributor to respiratory disease-related deaths and currently ran…
View article: Asthma and Cardiovascular Diseases: Navigating Mutual Pharmacological Interferences
Asthma and Cardiovascular Diseases: Navigating Mutual Pharmacological Interferences Open
View article: Dynamic and prognostic proteomic associations with FEV<sub>1</sub>decline in chronic obstructive pulmonary disease
Dynamic and prognostic proteomic associations with FEV<sub>1</sub>decline in chronic obstructive pulmonary disease Open
Rationale Identification and validation of circulating biomarkers for lung function decline in COPD remains an unmet need. Objective Identify prognostic and dynamic plasma protein biomarkers of COPD progression. Methods We measured plasma …
View article: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area
Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area Open
View article: Chronic Obstructive Pulmonary Disease Exacerbations Increase the Risk of Subsequent Cardiovascular Events: A Longitudinal Analysis of the COPDGene Study
Chronic Obstructive Pulmonary Disease Exacerbations Increase the Risk of Subsequent Cardiovascular Events: A Longitudinal Analysis of the COPDGene Study Open
Background Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary disease (COPD). COPD exacerbations not only contribute to COPD progression but may also elevate the risk of CVD. This …