Explanipedia

Sodium Cantharidate Suppresses Tongue Cancer Via Pi3k/Akt Pathway Open

Na Lu, Ke Zhou, H. Ma · 2025

Aim or purpose: This study aims to clarify the molecular mechanism of sodium cantharidate (SCA) against tongue squamous cell carcinoma (TSCC) through network pharmacology and experimental validation. Previous studies have indicated the pot…

Andrographolide prevents necroptosis by suppressing the generation of reactive oxygen species Open

Na Lu, Qing Li, Linghan Duan, Rong Xu, Yaping Li , et al. · 2025

Andrographolide (Andro), a natural product extracted from the Chinese traditional medicine herb Andrographis paniculata, has been applied for the treatment of diverse inflammatory diseases. However, its effects on necroptosis, a lyt…

GL‐V9 inhibits Caspase‐11 activation‐induced pyroptosis by suppressing ALOX12‐mediated lipid peroxidation to alleviate sepsis Open

Li Chen, Dongsheng Bai, Jiaying Du, Jiawei Zhao, Chen Zhou , et al. · 2025

Background and Purpose Sepsis, caused by pathogen infection, poses a serious threat to human life. While the link between sepsis and pyroptosis via Caspase‐11 non‐canonical inflammasome activation is known, effective treatments remain lack…

Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines Open

Qin Li, Nan Lin, Zuheng Wang, Yuexi Chen, Yuli Xie , et al. · 2025

Metabolomics Analysis of the Mechanism of Yuquan Capsules in the Treatment of T2DM Rats Using UPLC/MS Open

Mengli Zhang, Zhien Tan, Min Ou, Taiping Li, Xiaonan Yang , et al. · 2025

YQC has the capacity to enhance blood lipid and transaminase levels, suppress the expression of inflammatory factors, and foster the homeostatic progression of metabolic circulation in rats with T2DM.

Analysis of Gene Regulatory Network and Transcription Factors in Different Tissues of the Stropharia rugosoannulata Fruiting Body Open

Jia Lu, Jing Yan, Na Lu, Jiling Song, Jiayao Lin , et al. · 2025

Stropharia rugosoannulata is a mushroom that is rich in nutrients and has a pleasant flavor. Its cultivation area is expanding rapidly due to its simplicity and diversity. However, the developmental mechanism of the fruiting body, which co…

Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C‐Jun‐mediated IL‐8 Autocrine Open

Kai Zhao, Tifan Sun, Qiruo Sun, Zhenzhong Chen, Tiepeng Wang , et al. · 2024

Tumor necrosis factor receptor‐associated factor 4 (TRAF4), an E3 ubiquitin ligase, is frequently overexpressed in tumors. Although its cytoplasmic role in tumor progression is well‐documented, the precise mechanisms underlying its nuclear…

Mangiferin attenuates lipopolysaccharide-induced neuronal injuries in primary cultured hippocampal neurons Open

Hong-Ling Tan, Dan Liang, Na Lu, Junli Zhang, Shiyan Zhang , et al. · 2024

Mangiferin, a naturally occurring potent glucosylxanthone, is mainly isolated from the Mangifera indica plant and shows potential pharmacological properties, including anti-bacterial, anti-inflammation, and antioxidant in sepsis-ind…

A Rapid Self−Assembling Peptide Hydrogel for Delivery of TFF3 to Promote Gastric Mucosal Injury Repair Open

Jialei Chen, Jing Luo, Di Su, Na Lu, Jiawei Zhao , et al. · 2024

Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unex…

Transcriptome Analysis Reveals Key Genes and Pathways Associated with Heat Stress in Pleurotus pulmonarius Open

Weike Wang, Na Lu, Jiayao Lin, Liqin Lai, Guanping Chen · 2024

Pleurotus pulmonarius is a medium temperature edible mushroom, and its yield and quality are severely affected by high temperature. However, the molecular mechanism of Pleurotus pulmonarius response to heat stress remains unknown. In this …

Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis induction Open

Shuyi Wu, Henghua Li, Di Su, Na Lu · 2024

Drug delivery systems (DDSs) have been developed to carry an appropriate payload into the tumour’s area, accomplishing the goals of minimising potential bodily harm and enhancing therapeutic efficacy. Here, we fabricated a one-pot method f…

Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier Open

Dongsheng Bai, Jiawei Zhao, Runde Wang, Jiaying Du, Chen Zhou , et al. · 2023

Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment, significantly curtailing the efficacy of these treatments and, in some cases, resulting in fatal consequences. Despite identifying intestinal epithelia…

[Physicochemical properties of a novel chiral self-assembling peptide R-LIFE-1 and its controlled release to exosomes]. Open

Xinyi Luo, Di Su, Na Lu, Yuan Wan, Guicen Liu , et al. · 2023

This research aims to investigate the encapsulation and controlled release effect of the newly developed self-assembling peptide R-LIFE-1 on exosomes. The gelling ability and morphological structure of the chiral self-assembling peptide (C…

Data from TRAF4 Maintains Deubiquitination of Caveolin-1 to Drive Glioblastoma Stemness and Temozolomide Resistance Open