Nabeel Nabulsi
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View article: Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT
Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT Open
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View article: Optimized reference region and the effect on test-retest reliability and detection of Parkinson’s disease with [<sup>11</sup>C]UCB-J
Optimized reference region and the effect on test-retest reliability and detection of Parkinson’s disease with [<sup>11</sup>C]UCB-J Open
[ 11 C]UCB-J is a radioligand targeting synaptic vesicle glycoprotein 2A, used to image synaptic density. For quantification, a small-volume centrum semiovale area was previously optimized as a [ 11 C]UCB-J reference region (CS2mL); howeve…
View article: Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study
Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study Open
The endocannabinoid system (ECS) plays a critical role in fear learning and maintenance and may, therefore, be implicated in the pathophysiology of posttraumatic stress disorder (PTSD). The exact role of cannabinoid receptor 1 (CB1R), a ke…
View article: Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease
Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease Open
INTRODUCTION Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated association…
View article: A novel approach for modeling <i>in vivo</i> enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase
A novel approach for modeling <i>in vivo</i> enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase Open
PET imaging allows the study of enzyme concentration and activity in vivo . The enzyme natural turnover , relevant for drug development, can be estimated if a suicide inhibitor drug is used. The main aim of this study was to develop a mo…
View article: Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study
Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study Open
Background The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD). Positron emission tomography (PET) studi…
View article: Network-based Molecular Constraints on in vivo Synaptic Density Alterations in Schizophrenia
Network-based Molecular Constraints on in vivo Synaptic Density Alterations in Schizophrenia Open
Converging neuroimaging, genetic, and post-mortem evidence highlights the fundamental role of synaptic density reductions in schizophrenia pathogenesis. However, the brain-wide spatial pattern of these alterations and the mechanisms underl…
View article: Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study
Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study Open
Background The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD). Positron emission tomography (PET) studi…
View article: Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [<sup>11</sup>C]UCB-J PET
Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [<sup>11</sup>C]UCB-J PET Open
Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using S…
View article: Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia Open
Dynamic brain immune function in individuals with posttraumatic stress disorder is rarely studied, despite evidence of peripheral immune dysfunction. Positron emission tomography brain imaging using the radiotracer [ 11 C]PBR28 was used to…
View article: Synaptic loss and its association with symptom severity in Parkinson’s disease
Synaptic loss and its association with symptom severity in Parkinson’s disease Open
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD…
View article: First-in-Human Study of<sup>18</sup>F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding
First-in-Human Study of<sup>18</sup>F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding Open
PET imaging of synaptic vesicle glycoprotein 2A allows for noninvasive quantification of synapses. This first-in-human study aimed to evaluate the kinetics, test-retest reproducibility, and extent of specific binding of a recently develope…
View article: Imaging a putative marker of brain cortisol regulation in alcohol use disorder
Imaging a putative marker of brain cortisol regulation in alcohol use disorder Open
This is the first in vivo examination of 11β-HSD1 availability in individuals with AUD. Our data suggest higher brain availability of the cortisol-regenerating enzyme 11β-HSD1 in people with AUD (vs. controls), and that higher vmPFC 11β-HS…
View article: Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights
Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights Open
[18F]FE-PE2I PET is a promising alternative to single positron emission computed tomography–based dopamine transporter (DAT) imaging in Parkinson’s disease. While the excellent discriminative power of [18F]FE-PE2I PET has been established,…
View article: Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study
Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study Open
Background In rodents, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive 11-dehydrocorticosterone to the active hormone corticosterone. Dysregulation of intracellular glucocorticoid action is implicated in …
View article: Evaluating infusion methods and simplified quantification of synaptic density <i>in vivo</i> with [<sup>11</sup>C]UCB-J and [<sup>18</sup>F]SynVesT-1 PET
Evaluating infusion methods and simplified quantification of synaptic density <i>in vivo</i> with [<sup>11</sup>C]UCB-J and [<sup>18</sup>F]SynVesT-1 PET Open
For some positron emission tomography studies, radiotracer is administered as bolus plus continuous infusion (B/I) to achieve a state of equilibrium. This approach can reduce scanning time and simplify data analysis; however, the method mu…
View article: Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease
Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease Open
This data-driven approach defined specific spatial patterns of synaptic density correlated with unique participant characteristics within the AD group. Our findings reinforce synaptic density as a robust biomarker of disease presence and s…
View article: Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults
Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults Open
Background: Centanafadine is an inhibitor of reuptake transporters for norepinephrine (NET), dopamine (DAT) and serotonin (SERT). Aims: This phase 1, adaptive-design positron emission tomography study investigated the occupancy time course…
View article: Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates Open
Purpose Currently, there are multiple active clinical trials involving poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of glioblastoma. The noninvasive quantification of baseline PARP expression using positron emission tomog…