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View article: Social Isolation Induces Sex‐Specific Differences in Behavior and Gut Microbiota Composition in Stress‐Sensitive Rats
Social Isolation Induces Sex‐Specific Differences in Behavior and Gut Microbiota Composition in Stress‐Sensitive Rats Open
Background Social isolation (SI) is an established rat model of chronic stress. We applied this to the stress‐sensitive Wistar Kyoto (WKY) strain to explore brain‐to‐gut interactions associated with mood. Whether SI stress‐induced behavior…
View article: Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner
Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner Open
Although effects of stress-induced anxiety on the gastrointestinal tract and enteric nervous system (ENS) are well studied, how ENS dysfunction impacts behaviour is not well understood. We investigated whether ENS modulation alters anxiety…
View article: Novel insights into mechanisms of inhibition of colonic motility by loperamide
Novel insights into mechanisms of inhibition of colonic motility by loperamide Open
Background It is well known that opiates slow gastrointestinal (GI) transit, via suppression of enteric cholinergic neurotransmission throughout the GI tract, particularly the large intestine where constipation is commonly induced. It is n…
View article: A Diet Enriched with Lacticaseibacillus rhamnosus HN001 and Milk Fat Globule Membrane Alters the Gut Microbiota and Decreases Amygdala GABA a Receptor Expression in Stress-Sensitive Rats
A Diet Enriched with Lacticaseibacillus rhamnosus HN001 and Milk Fat Globule Membrane Alters the Gut Microbiota and Decreases Amygdala GABA a Receptor Expression in Stress-Sensitive Rats Open
Brain signalling pathways involved in subclinical anxiety and depressed mood can be modulated via the gut brain axis (GBA), providing the potential for diet and dietary components to affect mood. We investigated behavioural, physiological …
View article: Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model
Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model Open
Gastrointestinal (GI) motility is largely dependent upon activity within the enteric nervous system (ENS) and is an important part of the digestive process. Dysfunction of the ENS can impair GI motility as is seen in the case of constipati…
View article: Human resident gut microbe <i>Bacteroides thetaiotaomicron</i> regulates colonic neuronal innervation and neurogenic function
Human resident gut microbe <i>Bacteroides thetaiotaomicron</i> regulates colonic neuronal innervation and neurogenic function Open
Bt, common gut bacteria, is critical in regulating enteric neuronal and enteroendocrine cell populations, and neurogenic colonic activity. This highlights the potential use of this resident gut bacteria for maintaining healthy gut function.
View article: AWE-09 Characterization of neuronal innervation & its supporting structures in germ-free,conventional & germ-free-mice recolonized with bacteroides-thetaiotaomicron
AWE-09 Characterization of neuronal innervation & its supporting structures in germ-free,conventional & germ-free-mice recolonized with bacteroides-thetaiotaomicron Open
Introduction The enteric nervous system (ENS) is located throughout the length of the gastrointestinal (GI) tract as a series of interconnected ganglionated plexi. It has the unique ability to orchestrate GI behavior independently of the c…