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View article: Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8
Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8 Open
After a peripheral nerve injury, Schwann cells (SCs), the myelinating glia of the peripheral nervous system, convert into repair cells that foster axonal regrowth, and then remyelinate or re-ensheath regenerated axons, thereby ensuring fun…
View article: HDAC8 controls hypoxia-induced conversion of sensory Schwann cells into repair cells
HDAC8 controls hypoxia-induced conversion of sensory Schwann cells into repair cells Open
Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), react to a PNS injury by converting into repair cells that foster axonal regrowth, and then remyelinate or re-ensheath regenerated axons, thereby ensuring fu…
View article: Repair oligodendrocytes demyelinating and disintegrating damaged axons after injury
Repair oligodendrocytes demyelinating and disintegrating damaged axons after injury Open
After a spinal cord injury, axons fail to regrow, which results in permanent loss of function 1 . This is in contrast with peripheral axons that can regrow efficiently after injury 2 . These differences are partly due to the different plas…
View article: Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease
Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease Open
Schwann cells, the myelinating glia of the peripheral nervous system, wrap axons multiple times to build their myelin sheath. Myelin is of paramount importance for axonal integrity and fast axon potential propagation. However, myelin is la…