Explanipedia

Characterizing the Immune Response in Pig-to-Human Heart Xenografts Using a Multimodal Diagnostic System Open

Alessia Giarraputo, Erwan Morgand, Jeffrey Stern, Fariza Mezine, Guillaume Coutance , et al. · 2025

BACKGROUND: Porcine genome editing has revolutionized xenotransplantation, recently enabling the first pig-to-human heart xenotransplants. However, the xenoimmune response in heart xenografts remains largely unexplored. This study aimed to…

Spinal Cord Infarction as a Complication of VA-ECMO With Microaxial Flow Pump in Cardiogenic Shock Open

Arushi Singh, Syed Zain Ali, Kelly Drozdowicz, Amit Alam, Randal Goldberg , et al. · 2025

Contemporary MCS carries a small but significant risk of SCI which is often irreversible. More data are required to guide anticoagulation strategies for MCS and mitigate risk.

Clinical Heart Xenotransplantation: A Beat or Two Away? Open

Imad Aljabban, Jacqueline I. Kim, Ian Jaffe, Karen Khalil, Jeffrey Stern , et al. · 2025

Donor HLA-DQ reactive B cells clonally expand under chronic immunosuppression and include atypical CD21<sup>low</sup>CD27<sup>−</sup>B cells with high-avidity germline B-cell receptors Open

Steven Russum, Ismail Sayin, Jasmine Shwetar, Eleonore Baughan, Jong Cheol Jeong , et al. · 2024

Long-term allograft survival is limited by humoral-associated chronic allograft rejection, suggesting inadequate constraint of humoral alloimmunity by contemporary immunosuppression. Heterogeneity in alloreactive B cells and the incomplete…

Decreased bleeding and thrombotic complications on extracorporeal membrane oxygenation support following an updated anticoagulation protocol Open

Michael Dorsey, Katherine G. Phillips, Les James, Emily G. Kelley, Erica Duff , et al. · 2024

A modified heparin monitoring protocol defined by a lower therapeutic anti-factor Xa assay target and a set partial thromboplastin time cutoff correlated with decreases in bleeding/thrombotic complications in patients on extracorporeal mem…

Outcomes of Donation After Circulatory Death Heart Transplantation Using Normothermic Regional Perfusion Open

Akshay Kumar, Amit Alam, Michael Dorsey, Les James, Syed A. Hussain , et al. · 2024

Outcomes after DCD heart transplantation using TA-NRP remain encouraging with acceptable rates of rejection, PGD, CAV, and survival at 1 year.

Anatomical considerations and surgical technique of porcine cardiac xenotransplantation Open

Syed T. Hussain, Akshay Kumar, Justin Chan, Les James, Deane E. Smith , et al. · 2024

Cold Static Storage Combined with Intraoperative Cardioplegia Protection Strategy Yields Low Primary Graft Dysfunction Open

Morna J. Dorsey, L James, S. Chen, Michael Allison, S. Shrivastava , et al. · 2024

Pulsatile ECMO Open

Douglas E. Vincent, Nader Moazami, David A. D’Alessandro, John F. Fraser, Silver Heinsar , et al. · 2024

Ascending Aorta Smoke Masquerading as Massive Thrombus in a Patient Bridged from Venoarterial ECMO to Heart Transplantation Open

Angelish Kumar, Erin Flattery, Jincy Thankachen, T. Jan, Alex Reyentovich , et al. · 2024

Outcomes of lung and heart-lung transplants utilizing donor after circulatory death with thoracoabdominal normothermic regional perfusion Open

Stephanie H. Chang, Travis C. Geraci, Greta L. Piper, Justin Chan, Les James , et al. · 2024

Generation of Pulsatile Flow using Clinical Continuous Flow Pumps Open

Joav Birjiniuk, Deane E. Smith, Eugene A. Grossi, Aubrey C. Galloway, Nader Moazami · 2023

The mechanical challenges in generating pulsatile flow with continuous flow devices have precluded their widespread adoption in clinical practice. New pulsatile pumps are needed to achieve adequate physiologic pulsatility with improved sid…

Are exceptions justified in the current heart allocation system? Open

Maarten Coemans, Amrusha Musunuru, Les James, Deane E. Smith, Nader Moazami , et al. · 2023

Based on waitlist mortality over a longer study period than previous analyses, high-priority exceptions are appropriately placed in the current heart allocation system. The current allocation system requires a large fraction of candidates …

Profound Left Ventricular Remodeling Associated with LAMP2 Cardiomyopathy Open

Barry J. Maron, William C. Roberts, Carolyn Y. Ho, Carrie Kitner, Tammy S. Haas , et al. · 2023

Mutations in the X-linked lysosome-associated membrane protein gene (LAMP2) result in a storage disease known as LAMP2 cardiomyopathy, a morphologic phenocopy of sarcomeric hypertrophic cardiomyopathy.1, 2 LAMP2 mutations are associated wi…

Donation after circulatory death significantly reduces waitlist times while not changing post–heart transplant outcomes: A United Network for Organ Sharing Analysis Open

Hosam F. Ahmed, Kevin Kulshrestha, John T. Kennedy, Amalia Gomez-Guzman, Jason W. Greenberg , et al. · 2023

Table of Contents Open

Jennifer Frontera, Ariane Lewis, Les James, Kara Melmed, Brendan Parent , et al. · 2023

Extracorporeal hemoadsorption in critically ill COVID-19 patients on VV ECMO: the CytoSorb therapy in COVID-19 (CTC) registry Open

J.W. Awori Hayanga, T. Song, Lucian A. Durham, Lawrence Garrison, Deane E. Smith , et al. · 2023

HHV-6 Myocarditis Progressing to Ventricular Standstill Requiring Cardiac Transplant Open

Stephanie Golob, Haider Nazeer, Bernard Kadosh, Randal Goldberg, Navneet Narula , et al. · 2023

Extracorporeal Membrane Oxygenation Impact on Host Transcriptomic Response in Severe Coronavirus Open

Deane E. Smith, Chandra Goparaju, Harvey I. Pass, Les James, Marjan Alimi , et al. · 2023

The international experience of in-situ recovery of the DCD heart: a multicentre retrospective observational study Open

John Louca, Marco Öchsner, Ashish S. Shah, Jordan Hoffman, Alexandra Debose-Scarlett , et al. · 2023

Abstracts of the 23rd Annual State of the Art Winter Symposium Open

William C. Chapman, Facs Asts, Karim J. Halazun, Elizabeth A. Pomfret, Thomas Peters , et al. · 2023

peer reviewed

Donation after circulatory death heart transplantation using normothermic regional perfusion:The NYU Protocol Open

Les James, V. Reed LaSala, F.J. Hill, Jennie Ngai, Alex Reyentovich , et al. · 2022

The use of cardiopulmonary bypass for thoraco-abdominal normothermic regional perfusion is a burgeoning option for improving the quality of organs from donation after cardiac death donors. Meticulous intraoperative management of donation a…

Position Statement on Vascular Access Safety for Percutaneous Devices in AMI Complicated by Cardiogenic Shock Open

Abdulla A. Damluji, Behnam Tehrani, Shashank S. Sinha, Marc D. Samsky, Timothy D. Henry , et al. · 2022

Efficacy of proning in acute respiratory distress syndrome on extracorporeal membrane oxygenation Open

Stephanie H. Chang, Deane E. Smith, Julius A. Carillo, P Sommer, Travis C. Geraci , et al. · 2022

Rebuttal From Dr James et al Open

Les James, Brendan Parent, Nader Moazami, Deane E. Smith · 2022

Tocilizumab Accelerates Recovery in Patients With Severe COVID-19 Pneumonia on Venovenous Extracorporeal Membrane Oxygenation Open

Tyler Lewis, Serena Arnouk, Bridget Toy, Travis C. Geraci, Julius A. Carillo , et al. · 2022

Interleukin - 2 Receptor Antagonists Induction Therapy in Simultaneous Heart - Kidney Transplantation Open

A. Samra, C. Gidea, T. Malik, N. Sikand, Robert A. Montgomery , et al. · 2022

The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement Open

Steven R. Messé, Jessica Overbey, Vinod H. Thourani, Alan J. Moskowitz, Annetine C. Gelijns , et al. · 2022

One-Year Outcomes With Venovenous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Open

Deane E. Smith, Stephanie H. Chang, Travis C. Geraci, Les James, Zachary N. Kon , et al. · 2022

Commentary: Normothermic regional perfusion: Ethical issues in thoracic organ donation: An important discussion, but stop the press! Open

Deane E. Smith, Nader Moazami · 2022

Nader Moazami YOU? Author Swipe