Nader Shakibazad
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View article: Breaking the barrier: a guidelines-based review of antiangiogenesis drug resistance in pediatric cancer therapy
Breaking the barrier: a guidelines-based review of antiangiogenesis drug resistance in pediatric cancer therapy Open
The growth and metastatic potential of most solid and hematological tumors are angiogenesis-dependent. Antiangiogenic therapies have demonstrated clinical advantages in the treatment of numerous tumor types. Nevertheless, resistance to ant…
View article: Assessing glucose 6-phosphate dehydrogenase activity in children with acute lymphoblastic leukemia and its relationship to disease activity
Assessing glucose 6-phosphate dehydrogenase activity in children with acute lymphoblastic leukemia and its relationship to disease activity Open
The G6PD activity of RBC is higher in childhood ALL than in the control group. Moreover, the G6PD activity of RBC in the blastic phase of leukemia was higher than that of patients in remission.
View article: Association between Transfusion-Related Iron Overload and Liver Fibrosis in Survivors of Pediatric Leukemia: A Cross-Sectional Study
Association between Transfusion-Related Iron Overload and Liver Fibrosis in Survivors of Pediatric Leukemia: A Cross-Sectional Study Open
Transfusion-associated iron overload does not have a significant correlation with severe liver fibrosis. FibroScan® is not a sensitive tool for detecting early stages of fibrosis in survivors of pediatric leukemia.
View article: Cardioprotective effects of deferoxamine in acute and subacute cardiotoxicities of doxorubicin: a randomized clinical trial
Cardioprotective effects of deferoxamine in acute and subacute cardiotoxicities of doxorubicin: a randomized clinical trial Open
View article: The efficacy of <i>Allium ampeloprasum</i> L. in reducing neutrophil recovery time in childhood cancer with febrile neutropenia: a randomized, double-blind, placebo-controlled trial.
The efficacy of <i>Allium ampeloprasum</i> L. in reducing neutrophil recovery time in childhood cancer with febrile neutropenia: a randomized, double-blind, placebo-controlled trial. Open
A fresh, lyophilized extract from deciduous leaves of A. ampeloprasum L. can effectively shorten the ANC recovery time leading to an earlier release from the hospital. The trial was registered in the Iranian Registry of Clinical Tri…
View article: The protective role of deferoxamine in the prevention of doxorubicin-induced hepatic fibrosis in children: A randomized controlled clinical trial
The protective role of deferoxamine in the prevention of doxorubicin-induced hepatic fibrosis in children: A randomized controlled clinical trial Open
The protective role of deferoxamine in the prevention of doxorubicin-induced hepatic fibrosis in children: A randomized controlled clinical trial
View article: An evaluation of ascitic calprotectin for diagnosis of ascitic fluid infection in children with cirrhosis
An evaluation of ascitic calprotectin for diagnosis of ascitic fluid infection in children with cirrhosis Open
Background The most common infection in children with the hepatic disease with or without cirrhotic ascites is spontaneous bacterial peritonitis (SBP), which occurs in the absence of an evident intra-abdominal source of infection. The pres…
View article: Overview the Causes of Early Deaths and Advance Supportive Care in Children with Acute Lymphoblastic Leukemia: A Systematic Review
Overview the Causes of Early Deaths and Advance Supportive Care in Children with Acute Lymphoblastic Leukemia: A Systematic Review Open
Overview the Causes of Early Deaths and Advance Supportive Care in Children with Acute Lymphoblastic Leukemia: A Systematic Review
View article: Case series of bloody sweating; a scary event for families
Case series of bloody sweating; a scary event for families Open
View article: Evaluation of Microbial Resistance Pattern in Children with Urinary Tract Infection in Bushehr between 2017 and 2018
Evaluation of Microbial Resistance Pattern in Children with Urinary Tract Infection in Bushehr between 2017 and 2018 Open
Background and Aim: Urinary tract infection is one of the most common childhood illnesses that can lead to complications such as hypertension and kidney failure. The aim of this study was to evaluate microbial resistance and sensitivity an…
View article: Acute Renal Failure: A Rare Initial Presentation of Acute Lymphoblastic Leukemia
Acute Renal Failure: A Rare Initial Presentation of Acute Lymphoblastic Leukemia Open
Acute lymphoblastic leukemia has several presentations associated with bone marrow and extramedullary involvement. The unusual presentation may be due to the infiltration of leukemic cells in any organ. An 11-year-old girl presented with f…
View article: Parameters of tissue iron overload and cardiac function in patients with thalassemia major and intermedia
Parameters of tissue iron overload and cardiac function in patients with thalassemia major and intermedia Open
Background Noninvasive T2* magnetic resonance imaging (MRI) assessment can stratify the risk of subsequent cardiac dysfunction in β-thalassemia major (TM) and β-thalassemia intermedia (TI) patients. The normal level of N-terminal pro B-typ…
View article: The protective role of Deferoxamine in the prevention of hepatic fibrosis in children treated with Doxorubicin: a randomized controlled clinical trial
The protective role of Deferoxamine in the prevention of hepatic fibrosis in children treated with Doxorubicin: a randomized controlled clinical trial Open
Background: Hepatic fibrosis is an ominous sign which may follow treatment with Doxorubicin (DOX) chemotherapy. The aim of this study was investigating the protective effect of Deferoxamine (DFO) against hepatic fibrosis in treatment-naïve…
View article: Extramedullary manifestations in acute lymphoblastic leukemia in children: a systematic review and guideline-based approach of treatment.
Extramedullary manifestations in acute lymphoblastic leukemia in children: a systematic review and guideline-based approach of treatment. Open
The clinicians must become familiar with these extramedullary presentations of ALL in pediatrics to avoid the delayed diagnosis of this disease and increase the probable chance of survival by early detection.
View article: A novel frame-shift deletion in FANCF gene causing autosomal recessive Fanconi anemia: a case report
A novel frame-shift deletion in FANCF gene causing autosomal recessive Fanconi anemia: a case report Open
View article: Evaluation of intima-media thickness of common carotid artery in thalassemia patients compared to healthy individuals
Evaluation of intima-media thickness of common carotid artery in thalassemia patients compared to healthy individuals Open
View article: A Study of Intracoronary Injection of Hematopoietic Stem Cells in Pediatric Dilated Cardiomyopathy: Is It an Applicable Solution for Critically Ill Patients?
A Study of Intracoronary Injection of Hematopoietic Stem Cells in Pediatric Dilated Cardiomyopathy: Is It an Applicable Solution for Critically Ill Patients? Open
Background: Benefits of stem cell therapy on remodelling and cardiac function have been described in adults with dilated cardiomyopathy and acute myocardial infarction. Objectives: We investigated the effect of this treatment modality amon…
View article: Evaluation of intima-media thickness of common carotid artery in thalassemia patients compared to healthy individuals
Evaluation of intima-media thickness of common carotid artery in thalassemia patients compared to healthy individuals Open
Evaluation of intima-media thickness of common carotid artery in thalassemia patients compared to healthy individuals
View article: The Relationship of Birth Weight, Feeding and Gestational Age with Serum Copper and Zinc in Premature Neonates
The Relationship of Birth Weight, Feeding and Gestational Age with Serum Copper and Zinc in Premature Neonates Open
Introduction: Zinc and copper have a main role as nutrients in the growth and development of neonates. Aim: To evaluate the relationship of birth weight, feeding, and Gestational Age (GA) with serum copper and zinc in preterm neonates. Mat…
View article: Serum Folate and Vitamin B12 Levels in Survivors of Childhood Malignancy in Southern Iran
Serum Folate and Vitamin B12 Levels in Survivors of Childhood Malignancy in Southern Iran Open
Background: Folate and vitamin B12 have a number of biologic roles that make them important in hematological disorders and malignancy. In the present study, we have assessed serum folate and vitamin B12 levels and their associated variable…
View article: Simultaneous Occurrence of Multifocal Osteomyelitis in a Child with Acute Lymphoblastic Leukemia: A Rare Manifestation During the Maintenance Phase of Treatment
Simultaneous Occurrence of Multifocal Osteomyelitis in a Child with Acute Lymphoblastic Leukemia: A Rare Manifestation During the Maintenance Phase of Treatment Open
Introduction: Acute lymphoblastic leukemia (ALL) has various clinical manifestations due to bone marrow or extra medullary involvement. Osteomyelitis may occur as the first presentation or relapsing sign of ALL. Multifocal osteomyelitis in…
View article: Effect of ursodeoxycholic acid and vitamin E in the prevention of liver injury from methotrexate in pediatric leukemia
Effect of ursodeoxycholic acid and vitamin E in the prevention of liver injury from methotrexate in pediatric leukemia Open
Low-dose methotrexate does not cause significant liver fibrosis in pediatric leukemia. UDCA and vitamin E have minimal roles in hepatoprotection among pediatric patients with ALL.
View article: Buparvaquone Intoxication: Report of a Life-Threatening Thrombocytopenia in a Child and Review of Literature
Buparvaquone Intoxication: Report of a Life-Threatening Thrombocytopenia in a Child and Review of Literature Open
Drug induced thrombocytopenia is uncommon cause of life-threatening bleeding. The mechanisms may include bone marrow suppression or antibody-mediated platelet destruction. We report the case of a two-year-old boy with incedental ingestion …
View article: Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis
Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis Open
Cytomegalovirus (CMV) retinitis is one of the rare but debilitating presentations of the CMV infection in children with leukemia. Herein, we report a 12-year-old boy with acute myeloid leukemia complicated by rapid progressive visual loss …
View article: Neurological Crises after Discontinuation of Nitisinone (NTBC) Treatment in 3 Cases of Tyrosinemia
Neurological Crises after Discontinuation of Nitisinone (NTBC) Treatment in 3 Cases of Tyrosinemia Open
Tyrosinemia Type 1 is a hereditary disorder with liver, kidney and nervous system involvement. We report 3 children developed diaphragmatic paralysis requiring mechanical ventilation after discontinuation of NTBC treatment. In patients wit…
View article: Colonic basidiobolomycosis with liver involvement masquerading as gastrointestinal lymphoma: a case report and literature review
Colonic basidiobolomycosis with liver involvement masquerading as gastrointestinal lymphoma: a case report and literature review Open
Basidiobolomycosis is an unusual fungal skin infection that rarely involves the gastrointestinal tract. This study reported a 5-year-old boy with gastrointestinal basidiobolomycosis that had been misdiagnosed as gastrointestinal lymphoma. …
View article: Acquired Vitamin K Deficiency as Unusual Cause of Bleeding Tendency in Adults: A Case Report of a Nonhospitalized Student Presenting with Severe Menorrhagia
Acquired Vitamin K Deficiency as Unusual Cause of Bleeding Tendency in Adults: A Case Report of a Nonhospitalized Student Presenting with Severe Menorrhagia Open
We report a rare case of acquired vitamin K deficiency presenting with severe menorrhagia and without any gynecological problem. Partial thromboplastin time (59.2 seconds) and prothrombin time (33.1 seconds, INR: 5.97) were considerably pr…
View article: A Child with Left Femoral Pain and Limping
A Child with Left Femoral Pain and Limping Open
View article: Esthesioneuroblastoma Presenting with Bilateral Proptosis and Blindness in a Child: A Case Report
Esthesioneuroblastoma Presenting with Bilateral Proptosis and Blindness in a Child: A Case Report Open
Esthesioneuroblastoma is a rare malignant tumour of the olfactory epithelium. The most common symptom is related to unilateral nasal obstruction. It rarely presents with bilateral proptosis and blindness. We report a 21-month-old girl with…
View article: Evaluation of Metabolic Syndrome and Related Factors in Children Affected by Acute Lymphoblastic Leukemia.
Evaluation of Metabolic Syndrome and Related Factors in Children Affected by Acute Lymphoblastic Leukemia. Open
Being overweight is a complication of ALL treatment, which is associated with elevated blood leptin level and BMI Z-score. Therefore, MS criteria, such as BP, weight, and serum triglyceride level, should be taken into account in eac…