Nadia Abdelouahab
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View article: A stepwise approach to designing and delivering the SCHeLTI trial community-family-mother-child obesity prevention intervention
A stepwise approach to designing and delivering the SCHeLTI trial community-family-mother-child obesity prevention intervention Open
This paper describes the methods for the development and implementation of the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI) intervention, part of a World Health Organization-supported effort to prevent childhood obesity thr…
View article: Prospective harmonisation of four international randomised controlled trials in Canada, China, India and South Africa: the Healthy Life Trajectories Initiative
Prospective harmonisation of four international randomised controlled trials in Canada, China, India and South Africa: the Healthy Life Trajectories Initiative Open
Objectives The Healthy Life Trajectories Initiative (HeLTI) is an international multistudy consortium that supports the development and integration of four randomised controlled trials (RCTs) conducted in South Africa, India, China and Can…
View article: Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study
Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age—Results from the 3D Cohort Study Open
Introduction: Approximately 5.5% of pregnant women take antidepressants. Studies on prenatal exposure to antidepressants reported no association with child cognition, and inconsistent results with motor function and language development. A…
View article: In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes: A Prospective Birth Cohort Study
In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes: A Prospective Birth Cohort Study Open
Pregnant individuals are exposed to acetaminophen and caffeine, but it is unknown how these exposures interact with the developing gut microbiome. We aimed to determine whether acetaminophen and/or caffeine relate to the childhood gut micr…
View article: The relationship between persistent organic pollutants and Attention Deficit Hyperactivity Disorder phenotypes: Evidence from task-based neural activity in an observational study of a community sample of Canadian mother-child dyads
The relationship between persistent organic pollutants and Attention Deficit Hyperactivity Disorder phenotypes: Evidence from task-based neural activity in an observational study of a community sample of Canadian mother-child dyads Open
View article: Pregnancy and Neonatal Outcomes With Levothyroxine Treatment in Women With Subclinical Hypothyroidism Based on New Diagnostic Criteria: A Systematic Review and Meta-Analysis
Pregnancy and Neonatal Outcomes With Levothyroxine Treatment in Women With Subclinical Hypothyroidism Based on New Diagnostic Criteria: A Systematic Review and Meta-Analysis Open
Background Subclinical hypothyroidism (SCH) during pregnancy has been associated with multiple adverse maternal and neonatal outcomes. However, the potential benefits of levothyroxine (LT4) supplementation remain controversial. Variations …
View article: In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels
In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels Open
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic po…
View article: In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels
In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels Open
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic po…
View article: The association between prenatal concentrations of polybrominated diphenyl ether and child cognitive and psychomotor function
The association between prenatal concentrations of polybrominated diphenyl ether and child cognitive and psychomotor function Open
Background: Previous studies suggest a negative association between prenatal polybrominated diphenyl ethers (PBDEs) exposure and child cognitive and psychomotor development. However, the timing of the relationship between PBDE exposure and…
View article: Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): a multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity
Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): a multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity Open
Introduction Childhood overweight and obesity (OWO) is a primary global health challenge. Childhood OWO prevention is now a public health priority in China. The Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI), one of four tria…
View article: Blood manganese and cognitive and motor skills at age 6-7 in Canadian cohort GESTE
Blood manganese and cognitive and motor skills at age 6-7 in Canadian cohort GESTE Open
Background: Increasing evidence suggests that high exposure to manganese (Mn) may impair brain development. In Canada, Mn exposure comes from several environmental sources and the most common is drinking water. Our objective was to examine…
View article: SCHeLTI Platform: an Intervention Support System Tailored for a Randomized Controlled Trial (Preprint)
SCHeLTI Platform: an Intervention Support System Tailored for a Randomized Controlled Trial (Preprint) Open
BACKGROUND With the rapid development of eHealth technologies, the convenient exchange of health-related electronic data can promote interactive exchange of information between healthcare providers (HCPs) and patients, making the communic…
View article: miRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus
miRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus Open
Context Underlying mechanisms leading to gestational diabetes mellitus (GDM) are still under investigation, and it is unclear whether the placenta plays a role in triggering glucose intolerance or if its functions are modified in response …
View article: Associations of prenatal exposure to polybrominated diphenyl ethers and polychlorinated biphenyls with long-term gut microbiome structure: a pilot study
Associations of prenatal exposure to polybrominated diphenyl ethers and polychlorinated biphenyls with long-term gut microbiome structure: a pilot study Open
Background: The gut microbiome is influenced by early-life exposures, but—despite potentially enormous implications for child health—is understudied in environmental epidemiology. This pilot study is one of the first to explore in utero ex…
View article: Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort
Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort Open
View article: Association Between Meconium Acetaminophen and Childhood Neurocognitive Development in GESTE, a Canadian Cohort Study
Association Between Meconium Acetaminophen and Childhood Neurocognitive Development in GESTE, a Canadian Cohort Study Open
Acetaminophen is the only over-the-counter pain reliever that is not contraindicated during pregnancy, but recent studies have questioned whether acetaminophen is safe for the fetus, particularly the developing brain. This prospective birt…
View article: Advanced Neonatal Medicine in China: A National Baseline Database
Advanced Neonatal Medicine in China: A National Baseline Database Open
Previous surveys of neonatal medicine in China have not collected comprehensive information on workforce, investment, health care practice, and disease expenditure. The goal of the present study was to develop a national database of neonat…
View article: Univariate predictors of maternal concentrations of environmental chemicals: The MIREC study
Univariate predictors of maternal concentrations of environmental chemicals: The MIREC study Open
Our results demonstrated that inequitable distribution of exposure to chemicals among populations within a country can occur. Sociodemographic and lifestyle factors are an important component of a thorough risk assessment as they can impac…
View article: Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE
Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE Open