Nadia Y. Megally Abdo
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View article: Antiproliferative and Antiprostate Cancer Activities of Heterocyclic Compounds Derived from Cyclohexane-1,4-dione
Antiproliferative and Antiprostate Cancer Activities of Heterocyclic Compounds Derived from Cyclohexane-1,4-dione Open
2-Amino-6-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (3) was prepared from the reaction of cyclohexane-1,4-dione with elemental sulfur and malononitrile in 1,4-dioxane and triethylamine as catalyst. The latter compound reacted …
View article: Uses of Cyclohexane-1,4-Dione in the synthesis of heterocyclic compounds incorporating Tetrahydrobenzo[b]Thiophene: Synthesis, characterization and cytotoxicity
Uses of Cyclohexane-1,4-Dione in the synthesis of heterocyclic compounds incorporating Tetrahydrobenzo[b]Thiophene: Synthesis, characterization and cytotoxicity Open
Tetrahydrobenzo[b]Thiophene derivatives are well known as pharmaceutically active compounds and many of them are used as anti-cancer drugs. The aim of this work is to synthesize Tetrahydrobenzo[b]Thiophene derivative as a key starting …
View article: Synthesis, cytotoxic and anti-proliferative activity of novel thiophene, thieno[2,3-b]pyridine and pyran derivatives derived from 4,5,6,7-tetrahydrobenzo[b]thiophene derivative
Synthesis, cytotoxic and anti-proliferative activity of novel thiophene, thieno[2,3-b]pyridine and pyran derivatives derived from 4,5,6,7-tetrahydrobenzo[b]thiophene derivative Open
Novel tetrahydrobenzo[b]thienopyrole derivatives are synthesized from 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene (1) through its reaction with α-chloroacetone to give the corresponding N-alkyl derivative 3. Compound 3 undergoes re…