Nadia Haj Mohammad
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View article: A Novel TRG-N Prognostic Classification System for Esophageal Cancer Undergoing Neoadjuvant Therapy Followed by Esophagectomy
A Novel TRG-N Prognostic Classification System for Esophageal Cancer Undergoing Neoadjuvant Therapy Followed by Esophagectomy Open
Objective: To develop a new prognostic classification system centered on tumor regression grade (TRG) and ypN stage that can effectively stratify overall survival (OS) of esophageal cancer patients undergoing neoadjuvant therapy (NAT) foll…
View article: Adjuvant nivolumab after chemoradiotherapy and resection for patients with esophageal cancer: A real‐world matched comparison of overall survival
Adjuvant nivolumab after chemoradiotherapy and resection for patients with esophageal cancer: A real‐world matched comparison of overall survival Open
The Checkmate‐577 trial showed a significant disease‐free and a non‐significant overall survival benefit for nivolumab compared to placebo in esophageal or gastroesophageal junction (GEJ) cancer patients with residual disease after neoadju…
View article: Anifrolumab for Nonsystemic Cutaneous Lupus Erythematosus: Clinical Experience, Immunologic Insights, and Review of the Literature
Anifrolumab for Nonsystemic Cutaneous Lupus Erythematosus: Clinical Experience, Immunologic Insights, and Review of the Literature Open
Objective: Anifrolumab is approved for systemic lupus erythematosus (SLE). Its off-label use in non-systemic cutaneous lupus erythematosus (NSCLE) remains poorly characterized. We aimed to assess its effectiveness and safety in refractory …
View article: Gender-Based Patterns in Intracranial Aneurysm Site and Rupture Risk: A Single-Center Retrospective Cohort Study from the Caucasus region
Gender-Based Patterns in Intracranial Aneurysm Site and Rupture Risk: A Single-Center Retrospective Cohort Study from the Caucasus region Open
Background Intracranial aneurysms (IAs) are vascular abnormalities characterized by localized dilation of cerebral arteries, with a higher prevalence in females. Ruptured IAs can lead to subarachnoid hemorrhage, a life-threatening conditio…
View article: Impact of endoscopic ultrasonography with fine needle aspiration assessing clinical lymph node staging on radiotherapy treatment planning in esophageal cancer patients
Impact of endoscopic ultrasonography with fine needle aspiration assessing clinical lymph node staging on radiotherapy treatment planning in esophageal cancer patients Open
Summary Endoscopic ultrasound (EUS) combined with fine needle aspiration (FNA) can be of additional value to fluorine-18 labeled fluorodeoxyglucose positron emission tomography computed tomography (18FDG-PET-CT) for lymph node staging in e…
View article: STRONG II trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma – a single-arm multicentre phase II study
STRONG II trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma – a single-arm multicentre phase II study Open
Introduction For patients with perihilar cholangiocarcinoma (pCCA), surgical resection remains the sole treatment modality that can potentially result in cure. Unfortunately, the majority of patients present with unresectable tumours or ar…
View article: Patient preference trials in oncology: a scoping review and recommendations on reporting
Patient preference trials in oncology: a scoping review and recommendations on reporting Open
This review identified several challenges for PPTs in oncology. Future PPTs should take bias due to confounding and unequal group sizes arising from the preferential allocation into account and report on these issues, as these aspects are …
View article: Quality of Life Among Patients With Locally Advanced Pancreatic Cancer: A Prospective Nationwide Multicenter Study
Quality of Life Among Patients With Locally Advanced Pancreatic Cancer: A Prospective Nationwide Multicenter Study Open
Background: Health care providers of patients with cancer should discuss the impact of treatment, such as multiagent chemotherapy and surgery, on quality of life (QoL). However, in the era of shared decision-making, data on QoL in locally …
View article: Optimal timing for initiating first-line palliative systemic therapy in asymptomatic metastatic esophagogastric cancer: Insights from a European Delphi study
Optimal timing for initiating first-line palliative systemic therapy in asymptomatic metastatic esophagogastric cancer: Insights from a European Delphi study Open
In asymptomatic mEGC, immediate start of treatment is preferred by European experts. Consensus was established that treatment can be deferred for patients who prefer deferral and either have a pre-existent WHO/ECOG performance status of 2 …
View article: Real-world outcomes of the CROSS regimen in patients with resectable esophageal or gastro-esophageal junction adenocarcinoma: a nationwide cohort study in the Netherlands
Real-world outcomes of the CROSS regimen in patients with resectable esophageal or gastro-esophageal junction adenocarcinoma: a nationwide cohort study in the Netherlands Open
View article: Incomplete Neoadjuvant Chemoradiotherapy Negatively Impacts Pathological Complete Response and Overall Survival in Esophageal or Gastroesophageal Cancer
Incomplete Neoadjuvant Chemoradiotherapy Negatively Impacts Pathological Complete Response and Overall Survival in Esophageal or Gastroesophageal Cancer Open
View article: Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival
Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival Open
This study revealed that patients with impaired liver function treated with paclitaxel for breast and ovarian cancer in an advanced setting are at greater risk of developing hematological toxicity than patients with normal liver function a…
View article: Robotic thoracoscopic left paratracheal and cervical lymphadenectomy for recurrent esophageal adenocarcinoma: A case report
Robotic thoracoscopic left paratracheal and cervical lymphadenectomy for recurrent esophageal adenocarcinoma: A case report Open
View article: 785. MANAGEMENT OF ESOPHAGEAL CANCER WITH CONCURRENT CERVICAL NODE METASTASIS: A NATIONWIDE POPULATION-BASED COHORT STUDY
785. MANAGEMENT OF ESOPHAGEAL CANCER WITH CONCURRENT CERVICAL NODE METASTASIS: A NATIONWIDE POPULATION-BASED COHORT STUDY Open
Background In the Netherlands, the standard treatment of locally advanced, resectable esophageal cancer without metastasis is neoadjuvant chemoradiotherapy followed by esophagectomy. There is a small subset of patients that present with co…
View article: Tumor immune microenvironmental characteristics in Human Epidermal Growth Factor-2 (HER2) positive esophageal adenocarcinoma: A comparative analysis and biomarker study
Tumor immune microenvironmental characteristics in Human Epidermal Growth Factor-2 (HER2) positive esophageal adenocarcinoma: A comparative analysis and biomarker study Open
HER2 expression was associated with epithelial tumor characteristics. The HER2 positive TIME showed reduced immune cell infiltration but also lower expression of inhibitory signals associated with immune exhaustion, questioning the mechani…
View article: Endobronchial Ultrasonography to Assess and Evaluate Tracheobronchial Tree Invasion in cT4b Esophageal Cancer Patients Treated with Definitive Chemoradiotherapy: Assessment of Resectability
Endobronchial Ultrasonography to Assess and Evaluate Tracheobronchial Tree Invasion in cT4b Esophageal Cancer Patients Treated with Definitive Chemoradiotherapy: Assessment of Resectability Open
View article: Fecal, duodenal, and tumor microbiota composition of esophageal carcinoma patients, a longitudinal prospective cohort
Fecal, duodenal, and tumor microbiota composition of esophageal carcinoma patients, a longitudinal prospective cohort Open
Background The microbiome has been associated with chemotherapy and immune checkpoint inhibitor efficacy. How this pertains to resectable esophageal carcinoma is unknown. Our aim was to identify microbial signatures in resectable esophagea…
View article: Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival
Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival Open
Background: The anticancer drug paclitaxel is primarily metabolised in the liver. Previous studies indicated a correlation between impaired liver function and paclitaxel toxicity which may indicate dose reduction. Since evidence is limited…
View article: European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4)
European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4) Open
View article: Measurement of metabolite levels and treatment‐induced changes in hepatic metastases of gastro‐esophageal cancer using 7‐T phosphorus magnetic resonance spectroscopic imaging
Measurement of metabolite levels and treatment‐induced changes in hepatic metastases of gastro‐esophageal cancer using 7‐T phosphorus magnetic resonance spectroscopic imaging Open
Methods for early treatment response evaluation to systemic therapy of liver metastases are lacking. Tumor tissue often exhibits an increased ratio of phosphomonoesters to phosphodiesters (PME/PDE), which can be noninvasively measured by p…
View article: P02.07 Trial in progress: anti-PD1, capecitabine, and oxaliplatin for the first-line treatment of dMMR esophagogastric cancer (AuspiCiOus-dMMR): a proof-of-principle study (AuspiCiOus)
P02.07 Trial in progress: anti-PD1, capecitabine, and oxaliplatin for the first-line treatment of dMMR esophagogastric cancer (AuspiCiOus-dMMR): a proof-of-principle study (AuspiCiOus) Open
Background Doublet cytotoxic treatment demonstrates survival benefit over single drug therapies in patients with advanced esophagogastric cancer (EGC). Previous clinical data suggests an improved survival outcome in patients with microsate…
View article: Implementation of Best Practices in Pancreatic Cancer Care in the Netherlands
Implementation of Best Practices in Pancreatic Cancer Care in the Netherlands Open
Importance Implementation of new cancer treatment strategies as recommended by evidence-based guidelines is often slow and suboptimal. Objective To improve the implementation of guideline-based best practices in the Netherlands in pancreat…
View article: Assessing real-world representativeness of prospective registry cohorts in oncology: insights from patients with esophagogastric cancer
Assessing real-world representativeness of prospective registry cohorts in oncology: insights from patients with esophagogastric cancer Open
View article: 1575P Factors associated with uptake of adjuvant nivolumab in a nationwide esophageal cancer patient cohort
1575P Factors associated with uptake of adjuvant nivolumab in a nationwide esophageal cancer patient cohort Open
View article: Incidence, Stage, Treatment, and Survival of Noncardia Gastric Cancer
Incidence, Stage, Treatment, and Survival of Noncardia Gastric Cancer Open
Importance Gastric cancer is the fifth most common cancer worldwide, and investigating its incidence, characteristics, treatment, and outcomes over the past decades can help in selecting clinical strategies and future research directions. …
View article: Long-term health-related quality of life in patients with advanced esophagogastric cancer receiving first-line systemic therapy
Long-term health-related quality of life in patients with advanced esophagogastric cancer receiving first-line systemic therapy Open
View article: A population-based comparison of patients with metastatic esophagogastric carcinoma between Japan and the Netherlands
A population-based comparison of patients with metastatic esophagogastric carcinoma between Japan and the Netherlands Open
View article: Minimum and Optimal CA19-9 Response After Two Months Induction Chemotherapy in Patients With Locally Advanced Pancreatic Cancer
Minimum and Optimal CA19-9 Response After Two Months Induction Chemotherapy in Patients With Locally Advanced Pancreatic Cancer Open
Objective: This nationwide multicenter study aimed to define clinically relevant thresholds of relative serum CA19-9 response after 2 months of induction chemotherapy in patients with locally advanced pancreatic cancer (LAPC). Background: …
View article: Longitudinal immune monitoring of patients with resectable esophageal adenocarcinoma treated with Neoadjuvant PD-L1 checkpoint inhibition
Longitudinal immune monitoring of patients with resectable esophageal adenocarcinoma treated with Neoadjuvant PD-L1 checkpoint inhibition Open
The analysis of peripheral blood mononuclear cells (PBMCs) by flow cytometry holds promise as a platform for immune checkpoint inhibition (ICI) biomarker identification. Our aim was to characterize the systemic immune compartment in resect…
View article: Nationwide treatment and outcomes of intrahepatic cholangiocarcinoma
Nationwide treatment and outcomes of intrahepatic cholangiocarcinoma Open