Nadia Keller
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View article: Characterization of a novel <i>covS</i> SNP identified in Australian group A <i>Streptococcus</i> isolates derived from the M1 <sub>UK</sub> lineage
Characterization of a novel <i>covS</i> SNP identified in Australian group A <i>Streptococcus</i> isolates derived from the M1 <sub>UK</sub> lineage Open
Group A Streptococcus (GAS) is a human-adapted pathogen responsible for a variety of diseases. The GAS M1 UK lineage has contributed significantly to the recently reported increases in scarlet fever and invasive infections. However, the ba…
View article: Investigating group A <i>Streptococcus</i> antibiotic tolerance in necrotizing fasciitis
Investigating group A <i>Streptococcus</i> antibiotic tolerance in necrotizing fasciitis Open
Group A Streptococcus (GAS) necrotizing fasciitis (NF) is a difficult-to-treat bacterial infection associated with high morbidity and mortality despite extensive surgery and targeted antibiotic treatment. Difficult-to-treat infections are …
View article: Group A<i>Streptococcus</i>antibiotic tolerance in necrotizing fasciitis
Group A<i>Streptococcus</i>antibiotic tolerance in necrotizing fasciitis Open
Objectives Group A Streptococcus (GAS) necrotizing fasciitis (NF) is a difficult-to-treat bacterial infection associated with high morbidity and mortality despite extensive surgery and targeted antibiotic treatment. Bacteria surviving prol…
View article: Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria
Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria Open
Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacter…
View article: Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection
Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection Open
Within intensive care unit settings, multidrug-resistant (MDR) Acinetobacter baumannii is a major cause of ventilator-associated pneumonia, and hospital-associated outbreaks are becoming increasingly widespread. Antibiotic treatment of A. …
View article: Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis
Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis Open
The hydroxyquinoline analog PBT2 breaks resistance to polymyxin class antibiotics in polymyxin-resistant Gram-negative bacteria.
View article: Improved Biodistribution and Extended Serum Half-Life of a Bacteriophage Endolysin by Albumin Binding Domain Fusion
Improved Biodistribution and Extended Serum Half-Life of a Bacteriophage Endolysin by Albumin Binding Domain Fusion Open
The increasing number of multidrug-resistant bacteria intensifies the need to develop new antimicrobial agents. Endolysins are bacteriophage-derived enzymes that degrade the bacterial cell wall and hold promise as a new class of highly spe…
View article: Immunoglobulin Attenuates Streptokinase-Mediated Virulence inStreptococcus dysgalactiae Subspeciesequisimilis Necrotizing Fasciitis
Immunoglobulin Attenuates Streptokinase-Mediated Virulence inStreptococcus dysgalactiae Subspeciesequisimilis Necrotizing Fasciitis Open
Background Necrotizing fasciitis (NF) retains a very high mortality rate despite prompt and adequate antibiotic treatment and surgical debridement. Necrotizing fasciitis has recently been associated withStreptococcus dysgalactiae subspecie…
View article: Interferon α–Enhanced Clearance of Group A Streptococcus Despite Neutropenia
Interferon α–Enhanced Clearance of Group A Streptococcus Despite Neutropenia Open
These findings help to explain the rather discrepant facts of neutropenia but preserved antibacterial immune defenses in patients treated with IFN-α.