Nadia Sachewsky
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View article: Cell therapy with human interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection
Cell therapy with human interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection Open
View article: Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses
Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses Open
Interleukin-10 (IL-10)-producing group 2 innate lymphoid cells (ILC210) regulate inflammatory immune responses, yet their therapeutic potential remains largely unexplored. Here, we demonstrate that cell therapy with human ILC2
View article: Ectopic Expression of Neurod1 Is Sufficient for Functional Recovery following a Sensory–Motor Cortical Stroke
Ectopic Expression of Neurod1 Is Sufficient for Functional Recovery following a Sensory–Motor Cortical Stroke Open
Stroke is the leading cause of adult disability worldwide. The majority of stroke survivors are left with devastating functional impairments for which few treatment options exist. Recently, a number of studies have used ectopic expression …
View article: Cell therapy with IL-10-producing group 2 innate lymphoid cells suppresses Graft-versus-Host disease
Cell therapy with IL-10-producing group 2 innate lymphoid cells suppresses Graft-versus-Host disease Open
IL-10 producing group 2 innate lymphoid cells (ILC2 10 ) have immunoregulatory functions, and limit harmful immune responses across various tissues. Despite their crucial roles in maintaining immune homeostasis, the cell therapy potential …
View article: Direct reprogramming of astrocytes to neurons leads to functional recovery after stroke
Direct reprogramming of astrocytes to neurons leads to functional recovery after stroke Open
Stroke is the leading cause of adult disability with few treatment options for stroke survivors. Astrocyte reprogramming to neurons enables the targeted in vivo generation of new cells at the site of injury and represents a novel approach …
View article: Lineage tracing reveals the hierarchical relationship between neural stem cell populations in the mouse forebrain
Lineage tracing reveals the hierarchical relationship between neural stem cell populations in the mouse forebrain Open
Since the original isolation of neural stem cells (NSCs) in the adult mammalian brain, further work has revealed a heterogeneity in the NSC pool. Our previous work characterized a distinct, Oct4 expressing, NSC population in the periventri…
View article: Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord
Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord Open
The adult mammalian forebrain comprises two distinct populations of neural stem cells (NSCs): rare, Oct4 positive, primitive NSCs (pNSCs) and definitive NSC (dNSC) which are more abundant and express GFAP. The pNSCs are upstream of the dNS…
View article: Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke
Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke Open