Cyf Ramos‐Colon
YOU?
Author Swipe
View article: Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism Open
In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiate…
View article: Structure–Activity Relationships of [des-Arg<sup>7</sup>]Dynorphin A Analogues at the κ Opioid Receptor
Structure–Activity Relationships of [des-Arg<sup>7</sup>]Dynorphin A Analogues at the κ Opioid Receptor Open
Dynorphin A (Dyn A) is an endogenous ligand for the opioid receptors with preference for the κ opioid receptor (KOR), and its structure-activity relationship (SAR) has been extensively studied at the KOR to develop selective potent agonist…
View article: Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain
Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain Open
Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown tha…
View article: Various modifications of the amphipathic dynorphin <scp>A</scp> pharmacophore for rat brain bradykinin receptors
Various modifications of the amphipathic dynorphin <span>A</span> pharmacophore for rat brain bradykinin receptors Open
As a unique endogenous opioid ligand, dynorphin A shows paradoxical neuroexcitatory effects at bradykinin receptors, and the effects are known to be amplified by the upregulation of dynorphin A under chronic pain and inflammatory condition…