Nadine Schaefer
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View article: Electroconvulsive therapy reduces suicidality and all-cause mortality in refractory depression: A systematic review and meta-analysis of neurostimulation studies
Electroconvulsive therapy reduces suicidality and all-cause mortality in refractory depression: A systematic review and meta-analysis of neurostimulation studies Open
Depressive disorders are among the most common psychiatric disorders worldwide and associated with half of all suicides. There is robust evidence indicating that both electroconvulsive therapy (ECT) and repetitive transcranial magnetic sti…
View article: Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs Open
Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modifications in their chemical structure, e.g. insertion of a carboxamide moiety as a linker, which can potentially lead to al…
View article: Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration
Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration Open
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not u…
View article: Are the postmortem concentration changes of the synthetic cannabinoid cumyl-5F-P7AICA and its N-pentanoic acid metabolite dependent on the environmental conditions? – A systematic study following pulmonary administration to pigs
Are the postmortem concentration changes of the synthetic cannabinoid cumyl-5F-P7AICA and its N-pentanoic acid metabolite dependent on the environmental conditions? – A systematic study following pulmonary administration to pigs Open
The number of fatal cases involving synthetic cannabinoids (SCs) is increasing. However, interpretation of postmortem (PM) toxicological findings is challenging, due to unknown PM intervals and possible redistribution processes or instabil…
View article: Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs? Open
Many fatal intoxications have been reported in connection with the consumption of newer, highly potent synthetic cannabinoids. Yet, a possible postmortem redistribution (PMR) might complicate reliable interpretation of analytical results. …
View article: ‘Flying high?’—Jump from a height in a ‘Spice’ high?: A case report on the synthetic cannabinoid 5F‐MDMB‐P7AICA
‘Flying high?’—Jump from a height in a ‘Spice’ high?: A case report on the synthetic cannabinoid 5F‐MDMB‐P7AICA Open
Regarding the high potency of synthetic cannabinoids (SC), many intoxications and fatal cases are reported in literature. Here, we report on a fatality with 5F‐MDMB‐P7AICA contributing to the occurrence of death. A 31‐year‐old man died 10 …
View article: Are the <i>N</i>‐demethylated metabolites of U‐47700 more active than their parent compound? In vitro μ‐opioid receptor activation of <i>N</i>‐desmethyl‐U‐47700 and <i>N</i>,<i>N</i>‐bisdesmethyl‐U‐47700
Are the <i>N</i>‐demethylated metabolites of U‐47700 more active than their parent compound? In vitro μ‐opioid receptor activation of <i>N</i>‐desmethyl‐U‐47700 and <i>N</i>,<i>N</i>‐bisdesmethyl‐U‐47700 Open
Studies on the tissue distribution of the new synthetic opioid U‐47700 and its main metabolite N ‐desmethyl‐U‐47700 revealed about sixfold higher metabolite concentrations in pig brain as compared with the parent compound. To better assess…
View article: Comparison of <i>in vitro</i> and <i>in vivo</i> models for the elucidation of metabolic patterns of 7‐azaindole‐derived synthetic cannabinoids exemplified using cumyl‐5F‐P7AICA
Comparison of <i>in vitro</i> and <i>in vivo</i> models for the elucidation of metabolic patterns of 7‐azaindole‐derived synthetic cannabinoids exemplified using cumyl‐5F‐P7AICA Open
Due to the dynamic market involving synthetic cannabinoids (SCs), the determination of analytical targets is challenging in clinical and forensic toxicology. SCs usually undergo extensive metabolism, and therefore their main metabolites mu…
View article: Exploring the potential of using undergraduates’ knowledge, skills and experience in research methods as a proxy for capturing learning gain
Exploring the potential of using undergraduates’ knowledge, skills and experience in research methods as a proxy for capturing learning gain Open
Learning gain is a politicised concept within contemporary HE, and as such has been aligned with agendas of teaching excellence and learning outcomes but the extent to which it captures actual learning has yet to be clarified. Here, we rep…
View article: Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and Δ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs
Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and Δ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs Open
The parent compounds could be detected in every analyzed specimen with the exception of THC that was not present in dura and vitreous humor. Moderate concentrations were present in brain, the site of biological effect. Metabolite concentra…
View article: Multimodal MR imaging of acute and subacute experimental traumatic brain injury: Time course and correlation with cerebral energy metabolites
Multimodal MR imaging of acute and subacute experimental traumatic brain injury: Time course and correlation with cerebral energy metabolites Open
Background Traumatic brain injury (TBI) is one of the leading causes of death and permanent disability world-wide. The predominant cause of death after TBI is brain edema which can be quantified by non-invasive diffusion-weighted magnetic …