Nadish Goyal
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View article: INSPECTR assay protocol for sensitive SARS-CoV-2 enabled by rolling circle amplification
INSPECTR assay protocol for sensitive SARS-CoV-2 enabled by rolling circle amplification Open
This protocol defines the process for executing an INSPECTR assay to sensitively detect SARS-CoV-2 gRNA in a fully ambient temperature workflow. INSPECTR (for internal splint-pairing expression-cassette translation reaction), leverages the…
View article: Role of N-terminal domain of RAD54 in Branch Migration of Holliday Junctions
Role of N-terminal domain of RAD54 in Branch Migration of Holliday Junctions Open
Homologous recombination plays an important role in repairing the most harmful types of DNA damage, including DNA double-strand breaks and interstrand cross-links, in promoting faithful chromosome segregation during meiosis, and in telomer…
View article: Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors Open
RAD52 is a member of the homologous recombination (HR) pathway that is important for maintenance of genome integrity. While single RAD52 mutations show no significant phenotype in mammals, their combination with mutations in genes that cau…