Nadja Hellmann
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View article: Membrane binding of a cyanobacterial <scp>ESCRT</scp> ‐ <scp>III</scp> protein crucially involves the helix <i>α</i> 1‐3 hairpin conserved in all superfamily members
Membrane binding of a cyanobacterial <span>ESCRT</span> ‐ <span>III</span> protein crucially involves the helix <i>α</i> 1‐3 hairpin conserved in all superfamily members Open
IM30, the inner membrane‐associated protein of 30 kDa (also known as Vipp1) is essential for thylakoid membrane biogenesis and/or maintenance in chloroplasts and cyanobacteria. IM30 and its bacterial homolog PspA belong to the ESCRT‐III su…
View article: The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions
The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions Open
The phage shock protein A (PspA), a bacterial member of the endosomal sorting complexes required for transport (ESCRT)-III superfamily, forms rod-shaped helical assemblies that internalize membrane tubules. The N-terminal helix α0 of PspA …
View article: The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions
The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions Open
The phage shock protein A (PspA), a bacterial member of the ESCRT-III superfamily, forms rod-shaped helical assemblies that internalize membrane tubules. The N-terminal helix α0 of PspA (and other ESCRT-III members) has been suggested to a…
View article: Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies
Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies Open
Vesicle-inducing protein in plastids 1 (Vipp1) is critical for thylakoid membrane biogenesis and maintenance. Although Vipp1 has recently been identified as a member of the endosomal sorting complexes required for transport III superfamily…
View article: Structural basis for GTPase activity and conformational changes of the bacterial dynamin-like protein SynDLP
Structural basis for GTPase activity and conformational changes of the bacterial dynamin-like protein SynDLP Open
SynDLP, a dynamin-like protein (DLP) encoded in the cyanobacterium Synechocystis sp. PCC 6803, has recently been identified to be structurally highly similar to eukaryotic dynamins. To elucidate structural changes during guanosine triphosp…
View article: Hydrophobic mismatch and sequence specificity compete when transmembrane helix-helix interactions are measured with the TOXCAT assay
Hydrophobic mismatch and sequence specificity compete when transmembrane helix-helix interactions are measured with the TOXCAT assay Open
Genetic assays capable of measuring the propensity of transmembrane helices to oligomerize within the cytoplasmic membrane of the bacterium E. coli are frequently used when sequence-specificity in transmembrane helix-helix interactions is …
View article: CLiB – a novel cardiolipin-binder isolated <i>via</i> data-driven and <i>in vitro</i> screening
CLiB – a novel cardiolipin-binder isolated <i>via</i> data-driven and <i>in vitro</i> screening Open
CLiB, a cardiolipin-binding molecules, affects respiration of cardiolipin-containing bacteria as well as of mitochondria.
View article: Binding and/or hydrolysis of purine‐based nucleotides is not required for IM30 ring formation
Binding and/or hydrolysis of purine‐based nucleotides is not required for IM30 ring formation Open
IM30, the inner membrane‐associated protein of 30 kDa, is conserved in cyanobacteria and chloroplasts. Although its exact physiological function is still mysterious, IM30 is clearly essential for thylakoid membrane biogenesis and/or dynami…
View article: The Bacteriostatic Activity of 2-Phenylethanol Derivatives Correlates with Membrane Binding Affinity
The Bacteriostatic Activity of 2-Phenylethanol Derivatives Correlates with Membrane Binding Affinity Open
The hydrophobic tails of aliphatic primary alcohols do insert into the hydrophobic core of a lipid bilayer. Thereby, they disrupt hydrophobic interactions between the lipid molecules, resulting in a decreased lipid order, i.e., an increase…
View article: Mg<sup>2+</sup>-binding shifts the IM30 activity from membrane protection to membrane destabilization
Mg<sup>2+</sup>-binding shifts the IM30 activity from membrane protection to membrane destabilization Open
The inner membrane-associated protein of 30 kDa (IM30) is essential in chloroplasts and cyanobacteria. The spatio-temporal cellular localization of the protein appears to be highly dynamic and triggered by internal as well as external stim…
View article: IM30 IDPs form a membrane protective carpet upon super-complex disassembly
IM30 IDPs form a membrane protective carpet upon super-complex disassembly Open
Members of the phage shock protein A (PspA) family, including the inner membrane-associated protein of 30 kDa (IM30), are suggested to stabilize stressed cellular membranes. Furthermore, IM30 is essential in thylakoid membrane-containing c…
View article: Proton Leakage Is Sensed by IM30 and Activates IM30-Triggered Membrane Fusion
Proton Leakage Is Sensed by IM30 and Activates IM30-Triggered Membrane Fusion Open
The inner membrane-associated protein of 30 kDa (IM30) is crucial for the development and maintenance of the thylakoid membrane system in chloroplasts and cyanobacteria. While its exact physiological function still is under debate, it has …
View article: Odd haemoglobins in odd-toed ungulates: Impact of selected haemoglobin characteristics of the white rhinoceros (Ceratotherium simum) on the monitoring of the arterial oxygen saturation of haemoglobin
Odd haemoglobins in odd-toed ungulates: Impact of selected haemoglobin characteristics of the white rhinoceros (Ceratotherium simum) on the monitoring of the arterial oxygen saturation of haemoglobin Open
Our data enables the development of a rhinoceros-specific blood gas analysis algorithm, which allows for species-specific calculation of SaO2 levels in anaesthetized animals. The inconspicuous absorbance spectra do not contribute to the sy…
View article: Mg2+ binding triggers rearrangement of the IM30 ring structure, resulting in augmented exposure of hydrophobic surfaces competent for membrane binding
Mg2+ binding triggers rearrangement of the IM30 ring structure, resulting in augmented exposure of hydrophobic surfaces competent for membrane binding Open
The "inner membrane-associated protein of 30 kDa" (IM30), also known as "vesicle-inducing protein in plastids 1" (Vipp1), is found in the majority of photosynthetic organisms that use oxygen as an energy source, and its occurrence appears …
View article: Additional file 4: of Diversity, evolution, and function of myriapod hemocyanins
Additional file 4: of Diversity, evolution, and function of myriapod hemocyanins Open
Data S1. Nucleotide sequences of the Hc and PPO cDNAs and gene identified in this study. (ZIP 81 kb)
View article: P2X-Receptor Antagonists Inhibit the Interaction of S. aureus Hemolysin A with Membranes
P2X-Receptor Antagonists Inhibit the Interaction of S. aureus Hemolysin A with Membranes Open
The pore forming hemolysin A, Hla, is a major virulence factor of Staphylococcus aureus. Apparently, 1–2 pore(s) per cell suffice(s) to cause cell death. Accumulated experimental evidence points towards a major role of ATP-gated purinergic…
View article: Repair of a Bacterial Small β-Barrel Toxin Pore Depends on Channel Width
Repair of a Bacterial Small β-Barrel Toxin Pore Depends on Channel Width Open
Membrane repair emerges as an innate defense protecting target cells against bacterial pore-forming toxins. Here, we report the first paradigm of Ca 2+ -dependent repair following attack by a small β-pore-forming toxin, namely, plasmid-enc…
View article: Target Nanoparticles for Therapy - SANS and DLS of Drug Carrier Liposomes and Polymer Nanoparticles
Target Nanoparticles for Therapy - SANS and DLS of Drug Carrier Liposomes and Polymer Nanoparticles Open
T arget Nano-Pharmaceutics shall improve therapy and diagnosis of severe diseases, e.g. cancer, by individual targeting of drug-loaded nano-pharmaceuticals towards cancer cells, and drug uptake receptors in other diseases. Specific ligands…
View article: Entrapment and characterization of functional allosteric conformers of hemocyanin in sol–gel matrices
Entrapment and characterization of functional allosteric conformers of hemocyanin in sol–gel matrices Open
Entrapment of hemocyanin in sol–gel stabilizes conformations scarcely populated in solution, allowing for their structural and functional analysis.
View article: Extraordinary stability of hemocyanins from L. polyphemus and E. californicum studied using infrared spectroscopy from 294 to 20 K
Extraordinary stability of hemocyanins from L. polyphemus and E. californicum studied using infrared spectroscopy from 294 to 20 K Open
Infrared spectroscopic evidence of a high stability towards exposure to sub-zero temperatures for hemocyanins from the arthropods Limulus polyphemus and Eurypelma californicum.