Nadja Lehwald
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View article: Management of intrahepatic cholangiocarcinoma in a patient with Caroli's disease: a case report and literature review
Management of intrahepatic cholangiocarcinoma in a patient with Caroli's disease: a case report and literature review Open
Caroli's disease is a rare congenital disorder characterized by cystic dilatations of the intrahepatic bile ducts, often leading to recurrent bacterial cholangitis, biliary lithiasis, and cirrhosis. In 7%–16% of cases, it progresses to int…
View article: Predictive factors of 90-day mortality after curative hepatic resection for hepatocellular carcinoma: a western single-center observational study
Predictive factors of 90-day mortality after curative hepatic resection for hepatocellular carcinoma: a western single-center observational study Open
Purpose The aim of this study was to identify predictive risk factors associated with 90-day mortality after hepatic resection (HR) in hepatocellular carcinoma (HCC). Methods All patients undergoing elective resection for HCC from a single…
View article: Wnt/β-catenin signaling activation promotes lipogenesis in the steatotic liver via physical mTOR interaction
Wnt/β-catenin signaling activation promotes lipogenesis in the steatotic liver via physical mTOR interaction Open
Background and aims Wnt/β-catenin signaling plays an important role in regulating hepatic metabolism. This study is to explore the molecular mechanisms underlying the potential crosstalk between Wnt/β-catenin and mTOR signaling in hepatic …
View article: Optimizing Growth of the Future Liver Remnant and Making In-Situ Liver Transsection Safe—A Standardized Approach to ISLT or ALPPS
Optimizing Growth of the Future Liver Remnant and Making In-Situ Liver Transsection Safe—A Standardized Approach to ISLT or ALPPS Open
In-situ splitting of the liver before extended resection has gained broad attention. This two-step procedure requires several measures to make an effective and safe procedure. Although the procedure is performed in many institutions, there…
View article: Quality of Life in Patients with Pancreatic Cancer before and during the COVID-19 Pandemic
Quality of Life in Patients with Pancreatic Cancer before and during the COVID-19 Pandemic Open
Background: Coronavirus disease 19 (COVID-19) substantially affects cancer patients due to adverse outcomes and disruptions in cancer care. Recent studies have indicated the additional stress and anxiety burden arising from the pandemic an…
View article: Vertical traction device prevents abdominal wall retraction and facilitates early primary fascial closure of septic and non-septic open abdomen
Vertical traction device prevents abdominal wall retraction and facilitates early primary fascial closure of septic and non-septic open abdomen Open
Purpose One of the major challenges in the management of patients with septic and non-septic open abdomen (OA) is to control abdominal wall retraction. The aim of this study was to evaluate the impact of a novel vertical traction device (V…
View article: Peridural Anesthesia and Cancer-Related Survival after Surgery for Pancreatic Cancer—A Retrospective Cohort Study
Peridural Anesthesia and Cancer-Related Survival after Surgery for Pancreatic Cancer—A Retrospective Cohort Study Open
Background: In patients with prostatic and breast cancer the application of peridural anesthesia (PDA) showed a beneficial effect on prognosis. This was explained by reduced requirements for general anesthetics and perioperative opioids as…
View article: Liver resection and ablation for squamous cell carcinoma liver metastases.
Liver resection and ablation for squamous cell carcinoma liver metastases. Open
BACKGROUND: Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after l…
View article: Liver resection and ablation for squamous cell carcinoma liver metastases
Liver resection and ablation for squamous cell carcinoma liver metastases Open
Background Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after li…
View article: Site of Relapse of Ductal Adenocarcinoma of the Pancreas Affects Survival after Multimodal Therapy
Site of Relapse of Ductal Adenocarcinoma of the Pancreas Affects Survival after Multimodal Therapy Open
Background: Ductal adenocarcinoma of the pancreas (PDAC) remains one of the most lethal malignancies. To date, no guidelines exists for isolated resectable metachronous disease. It is still unknown, which patients may benefit from relapse …
View article: Platelets Boost Recruitment of CD133+ Bone Marrow Stem Cells to Endothelium and the Rodent Liver—The Role of P-Selectin/PSGL-1 Interactions
Platelets Boost Recruitment of CD133+ Bone Marrow Stem Cells to Endothelium and the Rodent Liver—The Role of P-Selectin/PSGL-1 Interactions Open
We previously demonstrated that clinical administration of mobilized CD133+ bone marrow stem cells (BMSC) accelerates hepatic regeneration. Here, we investigated the potential of platelets to modulate CD133+BMSC homing to hepatic endotheli…
View article: Radical Surgery of Synchronous Oligometastatic Liver Lesions of the Ductal Adenocarcinoma of the Pancreas Results in Prolonged Survival
Radical Surgery of Synchronous Oligometastatic Liver Lesions of the Ductal Adenocarcinoma of the Pancreas Results in Prolonged Survival Open
Background The ductal adenocarcinoma of the pancreas (PDAC) remains one of the most lethal malignancies. The role of surgery for circumscribed synchronous hepatic lesions of PDAC remains controversial. Thus, the aim of our study was to com…
View article: Site of Relapse of the Ductal Adenocarcinoma of the Pancreas affects Survival after Multimodal Therapy
Site of Relapse of the Ductal Adenocarcinoma of the Pancreas affects Survival after Multimodal Therapy Open
Background The ductal adenocarcinoma of the pancreas (PDAC) remains one of the most lethal malignancies. To date, no guidelines exists for isolated resectable metachronous disease. It is still unclear, which patients may benefit from relap…
View article: Negative Pressure Wound Therapy vs Conventional Wound Treatment in Subcutaneous Abdominal Wound Healing Impairment
Negative Pressure Wound Therapy vs Conventional Wound Treatment in Subcutaneous Abdominal Wound Healing Impairment Open
ClinicalTrials.gov Identifier: NCT01528033.
View article: In situ split plus portal vein ligation (ISLT) – a salvage procedure following inefficient portal vein embolization to gain adequate future liver remnant volume prior to extended liver resection
In situ split plus portal vein ligation (ISLT) – a salvage procedure following inefficient portal vein embolization to gain adequate future liver remnant volume prior to extended liver resection Open
Background Right extended liver resection is frequently required to achieve tumor-free margins. Portal venous embolization (PVE) of the prospective resected hepatic segments for conditioning segments II/III does not always induce adequate …
View article: Dorsal Track Control (DTC): A Modified Surgical Technique for Atraumatic Handling of the Distal Esophagus in Esophagojejunostomy
Dorsal Track Control (DTC): A Modified Surgical Technique for Atraumatic Handling of the Distal Esophagus in Esophagojejunostomy Open
Surgical therapy for adenocarcinoma of the esophagogastric junction II requires distal esophagectomy, in which a transhiatal management of the lower esophagus is critical. The 'dorsal track control' (DTC) maneuver presented here facilitate…