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View article: Landiolol and Organ Failure in Patients With Septic Shock
Landiolol and Organ Failure in Patients With Septic Shock Open
Importance Patients with septic shock undergo adrenergic stress, which affects cardiac, immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects of catecholamine exposure and has been associated with reduc…
View article: Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial
Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial Open
Introduction In 2013, a single-centre study reported the safe use of esmolol in patients with septic shock and tachycardia who required vasopressor therapy for more than 24 hours. Although not powered to detect a change in mortality, marke…
View article: Follow-on RifAximin for the Prevention of recurrence following standard treatment of Infection with<i>Clostridium Difficile</i>(RAPID): a randomised placebo controlled trial
Follow-on RifAximin for the Prevention of recurrence following standard treatment of Infection with<i>Clostridium Difficile</i>(RAPID): a randomised placebo controlled trial Open
Background Clostridium difficile infection (CDI) recurs after initial treatment in approximately one in four patients. A single-centre pilot study suggested that this could be reduced using ‘follow-on’ rifaximin treatment. We aimed to asse…
View article: Intramedullary nail fixation versus locking plate fixation for adults with a fracture of the distal tibia: the UK FixDT RCT
Intramedullary nail fixation versus locking plate fixation for adults with a fracture of the distal tibia: the UK FixDT RCT Open
Background The best treatment for fractures of the distal tibia remains controversial. Most of these fractures require surgical fixation, but the outcomes are unpredictable and complications are common. Objectives To assess disability, qua…