Nagaraju Bashetti
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View article: First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease
First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease Open
Background The G protein‐coupled receptor GPR39 is heavily associated with the pathogenesis of neurologic disorders, including Alzheimer’s disease (AD) and related dementia (ADRD). Its dysregulation of zinc 2+ (Zn 2+ ) processes triggers m…
View article: First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease
First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease Open
Background The G protein‐coupled receptor GPR39 is heavily associated with the pathogenesis of neurologic disorders, including Alzheimer’s disease (AD) and related dementia (ADRD). Its dysregulation of zinc 2+ (Zn2+) processes triggers met…
View article: Exploring Microtubule Dynamics in Alzheimer's Disease: Longitudinal Assessment Using [<sup>11</sup>C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models
Exploring Microtubule Dynamics in Alzheimer's Disease: Longitudinal Assessment Using [<sup>11</sup>C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models Open
Background Brains affected by Alzheimer's disease (AD) exhibit senile plaques containing amyloid beta (Aβ) peptides and neurofibrillary tangles, formed when tau becomes hyperphosphorylated and disengages from microtubules (MTs). Early inst…
View article: Exploring Microtubule Dynamics in Alzheimer’s Disease: Longitudinal Assessment Using [11C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models
Exploring Microtubule Dynamics in Alzheimer’s Disease: Longitudinal Assessment Using [11C]MPC‐6827 PET Imaging in APP/PS1 and PS301S Mouse Models Open
Background Brains affected by Alzheimer’s disease (AD) exhibit senile plaques containing amyloid beta (Aß) peptides and neurofibrillary tangles, formed when tau becomes hyperphosphorylated and disengages from microtubules (MTs). Early inst…
View article: Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [<sup>11</sup>C]MPC‐6827 PET imaging in rodent models of Alzheimer's‐related pathology
Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [<sup>11</sup>C]MPC‐6827 PET imaging in rodent models of Alzheimer's‐related pathology Open
INTRODUCTION Microtubule (MT) stability is crucial for proper neuronal function. Understanding MT dysregulation is critical for connecting amyloid beta (Aβ) and tau‐based degenerative events and early changes in presymptomatic Alzheimer's …
View article: First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations
First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations Open
G-protein-coupled receptor 119 (GPR119) has emerged as a promising target for treating type 2 diabetes mellitus. Activating GPR119 improves glucose homeostasis, while suppressing appetite and weight gain. Measuring GPR119 levels in vivo co…
View article: Preliminary biological evaluations of first brain‐penetrant GPR119‐based radiotracer in rodents and non‐human primates
Preliminary biological evaluations of first brain‐penetrant GPR119‐based radiotracer in rodents and non‐human primates Open
Background G‐protein‐coupled receptors (GPCRs) plays a key role in regulating glucose metabolism. While GPR119 (an important GPCR) agonists have shown potential for improving neurologic and cognitive function in patients with AD and type2 …
View article: [18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates
[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates Open
Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging is recognized as the standard tool for cancer imaging, there are no clinically-…