Naglaa Elabd
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View article: Intestinal ultrasound as non-invasive method in assessment of ulcerative colitis activity
Intestinal ultrasound as non-invasive method in assessment of ulcerative colitis activity Open
View article: Role of Serum B-type Natriuretic Peptide, Cardiac Troponin I and Creatine kinase monophosphate levels in early detection of Cardiac dysfunction in COVID-19 infected patients
Role of Serum B-type Natriuretic Peptide, Cardiac Troponin I and Creatine kinase monophosphate levels in early detection of Cardiac dysfunction in COVID-19 infected patients Open
View article: Insights into correlations between H. pylori infection and chronic hepatitis C disease progression: A Comparative study in the Egyptian population
Insights into correlations between H. pylori infection and chronic hepatitis C disease progression: A Comparative study in the Egyptian population Open
Background: Accumulating evidence implicated H. pylori infection in the disease progression of patients with chronic liver. Highly virulent H. pylori mediate proinflammatory cytokines and ensuing inflammatory alterations. We aimed to asses…
View article: Promotive role of MBNL3 and PXN genes expressions with lncRNA PXN-AS1-L on gastric cancer
Promotive role of MBNL3 and PXN genes expressions with lncRNA PXN-AS1-L on gastric cancer Open
MBNL3, PXN, and lncRNA PXN-AS1-L expression levels can diagnose and predict gastric cancer and discriminate between metastatic and non-metastatic patients. The expression level of MBNL3 and lncRNA PXN-AS1-L can predict gastric cancer morta…
View article: Circulating miR-485-5p as a potential diagnostic and prognostic biomarker for HCV-related hepatocellular carcinoma
Circulating miR-485-5p as a potential diagnostic and prognostic biomarker for HCV-related hepatocellular carcinoma Open
View article: Frequency of spontaneous bacterial peritonitis among cirrhotic ascitic patients and predictors for its outcome in Menoufia University Hospitals
Frequency of spontaneous bacterial peritonitis among cirrhotic ascitic patients and predictors for its outcome in Menoufia University Hospitals Open
Background: Cirrhosis often leads to spontaneous bacterial peritonitis (SBP) development, a condition with a poor prognosis warranting liver transplantation. This study aimed to identify SBP frequency among cirrhotic patients with ascites …
View article: Bile level of cytokeratin 7 as a diagnostic marker for cholangiocarcinoma: a case-control study in Egyptian patients
Bile level of cytokeratin 7 as a diagnostic marker for cholangiocarcinoma: a case-control study in Egyptian patients Open
Background Cholangiocarcinoma (CCA) is an aggressive malignancy with a poor prognosis of less than 20% five-year survival rate. Early diagnosis is typically challenging due to asymptomatic characteristics at the earliest stages of the dise…
View article: Metabolic profiling during COVID-19 infection in humans: Identification of potential biomarkers for occurrence, severity and outcomes using machine learning
Metabolic profiling during COVID-19 infection in humans: Identification of potential biomarkers for occurrence, severity and outcomes using machine learning Open
Background After its emergence in China, the coronavirus SARS-CoV-2 has swept the world, leading to global health crises with millions of deaths. COVID-19 clinical manifestations differ in severity, ranging from mild symptoms to severe dis…
View article: FURIN, IFNL4, and TLR2 gene polymorphisms in relation to COVID-19 severity: a case–control study in Egyptian patients
FURIN, IFNL4, and TLR2 gene polymorphisms in relation to COVID-19 severity: a case–control study in Egyptian patients Open
Background and Aim A wide range of clinical manifestations and outcomes, including liver injury, have been reported in COVID-19 patients. We investigated the association of three substantial gene polymorphisms ( FURIN , IFNL4 , and TLR2 ) …
View article: Cytokines profile and their related genotypes in COVID-19: Correlation with disease severity and outcome in Egyptian patients
Cytokines profile and their related genotypes in COVID-19: Correlation with disease severity and outcome in Egyptian patients Open
Background and Aims: COVID-19-related pulmonary inflammation is linked to elevated plasma levels of a group of proinflammatory cytokines. We aim to identify the association between IL-6 rs1800795, IL-17 rs2275913, and IL-37 rs3811046 gene …
View article: Type 2 Diabetes Mellitus and Non-Metastatic Colorectal Cancer: A Retrospective Study on Survival and Toxicity Profiles
Type 2 Diabetes Mellitus and Non-Metastatic Colorectal Cancer: A Retrospective Study on Survival and Toxicity Profiles Open
T2DM is considered a risk factor for poor survival among CRC patients. Treatment related toxicity is not affected by the presence or absence of diabetes, yet neuropathy needs further studies for diabetic patients receiving oxaliplatin.
View article: Insights into the Correlation between Toll‐Like Receptor 2 Polymorphism and HBV‐Related Disease Progression and Occurrence of Hepatocellular Carcinoma: A Case‐Control Study in Egyptian Patients
Insights into the Correlation between Toll‐Like Receptor 2 Polymorphism and HBV‐Related Disease Progression and Occurrence of Hepatocellular Carcinoma: A Case‐Control Study in Egyptian Patients Open
Background and Aim . Hepatitis B virus (HBV) infection causes a variety of clinical manifestations, including liver cirrhosis and hepatocellular carcinoma (HCC). Toll‐like receptors (TLRs) have crucial functions in immune and inflammatory …
View article: Role of Mac-2-binding protein glycosylation isomer in assessment of liver fibrosis in patients with chronic hepatitis C virus receiving direct-acting antiviral agents
Role of Mac-2-binding protein glycosylation isomer in assessment of liver fibrosis in patients with chronic hepatitis C virus receiving direct-acting antiviral agents Open
We aimed to investigate the clinical usefulness of Mac-2-binding protein glycosylation isomer (M2BPGi) in liver fibrosis assessment within patients with chronic hepatitis C virus (HCV) at baseline and after direct-acting antiviral agent th…
View article: Impact of long-term eradication of chronic Hepatitis C infection using the direct-acting antiviral treatment on liver fibrosis parameters in Egyptian patients
Impact of long-term eradication of chronic Hepatitis C infection using the direct-acting antiviral treatment on liver fibrosis parameters in Egyptian patients Open
Background: Hepatitis C virus (HCV) treatment aims to halt the progression of fibrosis and reducing its complications.HCV-treatment has been enhanced by the development of all-oral DAAs with good efficacy and a reasonable side effect.Aims:…
View article: Risk of Surgery in Patients with Liver Cirrhosis
Risk of Surgery in Patients with Liver Cirrhosis Open
Background and aim: Chronic liver disease patients often undergo surgery for indications other than liver transplantation and may face increased perioperative risk due to surgical and anesthesia-related complications.The current study's ob…
View article: Study Cardiac Dysfunction as an Early Predictor of Esophageal Varices in Patients with Liver Cirrhosis
Study Cardiac Dysfunction as an Early Predictor of Esophageal Varices in Patients with Liver Cirrhosis Open
Background and aim: Due to the increased mortality and danger of bleeding, the presence of esophageal varices (EV) caused by portal hypertension is a serious concern in cirrhotic patients.60-80% of newly diagnosed cirrhotic patients have E…
View article: Long Non-Coding RNAs ASB16-AS1 and AFAP1-AS1: Diagnostic, Prognostic Impact and Survival Analysis in Colorectal Cancer
Long Non-Coding RNAs ASB16-AS1 and AFAP1-AS1: Diagnostic, Prognostic Impact and Survival Analysis in Colorectal Cancer Open
We propose the utilization of lncRNA ASB16-AS1 and lncRNA AFAP1-AS1 as biomarkers in diagnosis and prognosis estimation for CRC patients. Moreover, their value in early CRC patients may affect the assortment of target therapy and treatment…
View article: Toll- like receptor 2 polymorphism and IL-6 profile in relation to disease progression in chronic HBV infection: a case control study in Egyptian patients
Toll- like receptor 2 polymorphism and IL-6 profile in relation to disease progression in chronic HBV infection: a case control study in Egyptian patients Open
View article: Gut Microbiota Characteristics in Ulcerative Colitis and other Gastrointestinal Diseases
Gut Microbiota Characteristics in Ulcerative Colitis and other Gastrointestinal Diseases Open
such a causal relationship where improvement of the disease process, after gut microbiota modulation, is a strong indicator of gut microbiota role in the pathogenesis of this disease.
View article: Role of serum Adiponectin level in assessment of obese patients with Barrett's esophagus
Role of serum Adiponectin level in assessment of obese patients with Barrett's esophagus Open
Background: Obesity especially visceral obesity is an important independent risk factor for the development of gastro-esophageal reflux disease (GERD) and, Barrett's esophagus (BE).Aim: In this work, we aimed to evaluate serum adiponectin …
View article: Role of Serum Ascites Albumin Gradient (SAAG) and Portal Vein Congestion Index as Non-Invasive Methods for Prediction of Esophageal Varices in Cirrhotic Patients
Role of Serum Ascites Albumin Gradient (SAAG) and Portal Vein Congestion Index as Non-Invasive Methods for Prediction of Esophageal Varices in Cirrhotic Patients Open
Background and aim: Majority of cirrhotic patients develop varices, the rate of variceal bleeding is 10-30% yearly with death rate from bleeding is 17-57%.esophagogastroduodenoscopy (EGD) is an invasive and unpleasant technique carrying ra…
View article: B-type natriuretic peptide (BNP) in HCV-positive Egyptian patients: the impact of HCV eradication on plasma BNP levels
B-type natriuretic peptide (BNP) in HCV-positive Egyptian patients: the impact of HCV eradication on plasma BNP levels Open
Background Chronic hepatitis C virus (HCV) infection represents a major health-related burden in Egypt. HCV is considered as a major cardiovascular risk factor. BNP (B-type natriuretic peptide) has been determined as a credible diagnostic …
View article: Down regulation of miR-30a-5p and miR-182–5p in gastric cancer: Clinical impact and survival analysis
Down regulation of miR-30a-5p and miR-182–5p in gastric cancer: Clinical impact and survival analysis Open
View article: Hepatitis C core antigen: a simple predictive marker for treatment response to the new direct-acting antiviral drugs in chronic HCV Egyptian patients
Hepatitis C core antigen: a simple predictive marker for treatment response to the new direct-acting antiviral drugs in chronic HCV Egyptian patients Open
View article: Evaluation of MicroRNA-122 as a Biomarker for Chronic Hepatitis C Infection and as a Predictor for Treatment Response to Direct-Acting Antivirals
Evaluation of MicroRNA-122 as a Biomarker for Chronic Hepatitis C Infection and as a Predictor for Treatment Response to Direct-Acting Antivirals Open
The results demonstrated the possible function of microRNA-122 as an indicative tool for distinguishing chronic HCV patients from controls and in the assessment of the therapeutic reaction to DAAs.
View article: Differential expression of long noncoding RNAin hepatocellular carcinoma on top of chronic HCVand HBV infections
Differential expression of long noncoding RNAin hepatocellular carcinoma on top of chronic HCVand HBV infections Open
The differential expression of lncRNAs (ANRIL, hPVT1 and aHIF) might be of major worth in predicting the occurrence of HCC in cirrhotic patients related to chronic viral hepatitis and could be beneficial in the early management.
View article: Association Between the ACE (I/D) Gene Polymorphism and Hepatocellular Carcinoma Risk in Egyptian HCV Patients
Association Between the ACE (I/D) Gene Polymorphism and Hepatocellular Carcinoma Risk in Egyptian HCV Patients Open
Background: Hepatocellular carcinoma is one of the most fatal malignancies worldwide and is related to many risk factors. Chronic HCV is associated with a 20–30-fold increased risk for HCC. Angiotensin-converting enzyme (ACE) is overexpres…
View article: The Gamma-glutamyl Transpeptidase to Platelet Ratio (GPR) Predict Significant Liver Fibrosis and Cirrhosis in Chronic Egyptian HCV Patients
The Gamma-glutamyl Transpeptidase to Platelet Ratio (GPR) Predict Significant Liver Fibrosis and Cirrhosis in Chronic Egyptian HCV Patients Open
Background and aim: Non-invasive parameters of liver fibrosis are being widely incorporated and adopted in clinical practice, of them, 2 ratios APRI and FIB-4 were proposed and applied.The gamma-glutamyl transferase -toplatelet ratio (GPR)…
View article: The Diagnostic role of Soluble (sAxl) Level in Patients with Hepatocellular Carcinoma compared to Alpha-fetoprotein
The Diagnostic role of Soluble (sAxl) Level in Patients with Hepatocellular Carcinoma compared to Alpha-fetoprotein Open
Background and Aim: Hepatocellular carcinoma deemed for the plurality of primary liver cancers.Malignancy of the liver is the fourth most popular etiology of cancer mortality worldwide.The high mortality of HCC cases is linked to the delay…
View article: Study of the Relation between Endothelial Nitric Oxide Synthase G894T Gene Variants and Occurrence of Type II Hepatorenal Syndrome
Study of the Relation between Endothelial Nitric Oxide Synthase G894T Gene Variants and Occurrence of Type II Hepatorenal Syndrome Open
Background and study aim:The progress of hepatorenal syndrome (HRS) in hepatic patients is not yet understood.Nitric oxide level, through its impact on haemodynamic circulation, may be engaged in the progress of the disease.Our study expec…