Naglaa M. Hassan
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View article: Ertugliflozin, a SGLT-2 Inhibitor, Guards Against Thioacetamide-induced Liver Fibrosis: The Nrf2/HO-1 and TLR4/ TGF-β1 Pathways
Ertugliflozin, a SGLT-2 Inhibitor, Guards Against Thioacetamide-induced Liver Fibrosis: The Nrf2/HO-1 and TLR4/ TGF-β1 Pathways Open
Hepatic fibrogenesis is considered an epidemic health problem since it can lead to several insults that can be fatal. Ertugliflozin (Ertu), an inhibitor of the sodium-glucose cotransporter-2 (SGLT2), is one of the most recent anti-diabetic…
View article: Contribution of TP53 and MDM4 Genetic Polymorphisms as a Risk Factor in Non-Hodgkin Lymphoma in Adult Egyptian Patients
Contribution of TP53 and MDM4 Genetic Polymorphisms as a Risk Factor in Non-Hodgkin Lymphoma in Adult Egyptian Patients Open
Background: Non-Hodgkin Lymphoma (NHL) is an increasingly prevalent hematological malignancy in Egypt, highlighting the need for a better understanding of its genetic risk factors. The TP53 and MDM4 genes play critical roles in cellular ho…
View article: Isolation, molecular identification and in vitro screening of Talaromyces purpurogenus for the first report as lemon soft- rot causal agent in Egypt
Isolation, molecular identification and in vitro screening of Talaromyces purpurogenus for the first report as lemon soft- rot causal agent in Egypt Open
lemon (Citrus limon L.) is one of the fruit crops that is most widely cultivated worldwide. Seven isolates of Penicillium sp were isolated from infected lemon fruits with soft rot pathogen collected from different lemon farm's grown under …
View article: Prognostic impact of inhibitors of DNA binding proteins1 and inhibitors of DNA binding proteins4 genes expression on adult Egyptian patients with acute myeloid leukemia
Prognostic impact of inhibitors of DNA binding proteins1 and inhibitors of DNA binding proteins4 genes expression on adult Egyptian patients with acute myeloid leukemia Open
Background Acute myeloid leukemia (AML) pathogenesis and treatment are currently being better understood at an accelerated rate. Determining genetic and epigenetic changes that can identify patients who are at risk of poor outcomes is ther…
View article: PTCSC3, XIST, GAS5, UCA1, and HIFAL: Five lncRNAs Emerging as Potential Prognostic Players in Egyptian Adult Acute Myeloid Leukemia (AML) Patients
PTCSC3, XIST, GAS5, UCA1, and HIFAL: Five lncRNAs Emerging as Potential Prognostic Players in Egyptian Adult Acute Myeloid Leukemia (AML) Patients Open
Background and Aims So far, long noncoding RNAs (lncRNAs) signatures in acute myeloid leukemia (AML) are poorly understood. The present study aims to explore the prognostic significance of eleven cancer-related lncRNAs in bone marrow (BM) …
View article: Bone marrow microRNA-34a is a good indicator for response to treatment in acute myeloid leukemia
Bone marrow microRNA-34a is a good indicator for response to treatment in acute myeloid leukemia Open
miR-34a could be a beneficial diagnostic biomarker for AML patients. In addition, it serves as a good indicator for response to therapy, which could possibly identify patients who are refractory to treatment with 100% sensitivity and 75% s…
View article: Clinical features, laboratory characteristics, and outcome of ETP and TCRA/D aberrations in pediatric patients with T-acute lymphoblastic leukemia
Clinical features, laboratory characteristics, and outcome of ETP and TCRA/D aberrations in pediatric patients with T-acute lymphoblastic leukemia Open
Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few accepted prognostic factors that limit the efficiency of therapy. The aim of the current study was to assess the clinical and laboratory features o…
View article: Clinical and Molecular Characteristics of Patients with Mixed Phenotype Acute Leukemia
Clinical and Molecular Characteristics of Patients with Mixed Phenotype Acute Leukemia Open
MPAL is a complex entity with heterogeneous features. BCR::ABL1 is a common abnormality. BMT is associated with better OS.
View article: The expression level of ARF and p53 in AML patients, and their relation to patients' outcome
The expression level of ARF and p53 in AML patients, and their relation to patients' outcome Open
Background Acute myeloid leukemia (AML) is a cancer of hematopoietic progenitors characterized by gene mutations. The most popular deregulations are mutation and altered expression in the p53 gene, which is considered the guardian of the g…
View article: Evaluation of the HOXA9 and MEIS1 genes as a potential biomarker in adult acute myeloid leukemia
Evaluation of the HOXA9 and MEIS1 genes as a potential biomarker in adult acute myeloid leukemia Open
Background Acute myeloid leukemia (AML) is a heterogeneous disorder encompassing a set of hematopoietic tumors that develop when the myeloid precursor cells undergo disproportionate clonal proliferation. Homeobox A 9 ( HOXA9 ) is a pioneer…
View article: The study of long noncoding RNA SNHG5 and PANDAR genes expression in newly diagnosed egyptian adult acute myeloid leukemia patients
The study of long noncoding RNA SNHG5 and PANDAR genes expression in newly diagnosed egyptian adult acute myeloid leukemia patients Open
BACKGROUND: Due to their impact on crucial steps in hematopoiesis, long noncoding RNAs (lncRNAs) deregulation potentially accelerates the growth and development of blood cancers like acute myeloid leukemia (AML). The study aimed to look in…
View article: The prognostic role of C-KIT, TET1 and TET2 gene expression in Acute Myeloid Leukemia
The prognostic role of C-KIT, TET1 and TET2 gene expression in Acute Myeloid Leukemia Open
Aim was to assess the role of C-KIT , TET1 and TET2 expression in the diagnosis and prognosis of acute myeloblastic leukemia (AML). Methods The expression levels of C-KIT, TET1 and TET2 were assessed in the bone marrow (BM) aspirate of 152…
View article: Cancer Stem Cells as a Prognostic Biomarker and Therapeutic Target Using Curcumin/ Piperine Extract for Multiple Myeloma
Cancer Stem Cells as a Prognostic Biomarker and Therapeutic Target Using Curcumin/ Piperine Extract for Multiple Myeloma Open
MMCSCs in the bone marrow of MM-pCR patients can be utilized as a prognostic tool to predict recurrent multiple myeloma incidence. Also, the therapeutic potential of C/P extract as a prospective anti-MM drug targeting MMCSCs.
View article: Evaluation of CBP, CEBPA and DNMT3A genes in Diagnosis and Prognosis of Acute Myeloid Leukemia.
Evaluation of CBP, CEBPA and DNMT3A genes in Diagnosis and Prognosis of Acute Myeloid Leukemia. Open
Background : CBP , CEBPA and DNMT3A are tumor suppressor genes whose dysfunction has been reported in hematologic malignancies. Acute myeloid leukemia is the most common type of white cell neoplasm among adults. Our aim is to assess the ex…
View article: Significance of CD200 expression in patients with acute myeloid leukemia and its correlation with other prognostic markers
Significance of CD200 expression in patients with acute myeloid leukemia and its correlation with other prognostic markers Open
Background and Objectives: Acute myeloid leukemia (AML) known as cancer of blood and bone marrow is regarded as the commonest acute leukemia in adult patients.characterized by uncontrolled proliferation of hematopoietic progenitor cells wi…
View article: Impact of HOXB4 and PRDM16 Gene Expressions on Prognosis and Treatment Response in Acute Myeloid Leukemia Patients
Impact of HOXB4 and PRDM16 Gene Expressions on Prognosis and Treatment Response in Acute Myeloid Leukemia Patients Open
Further larger study should be conducted to verify that high PRDM16 and low HOXB4 gene expressions could be used as a poor prognostic predictor for AML. The correlation between PRDM16 and HOXB4 gene expressions and FLT3-ITD and NPM1 exon 1…
View article: Evaluating the Role of Cytokine Receptor-like Factor 2 and Janus Kinase 2 in Adult Acute Lymphoblastic Leukemia
Evaluating the Role of Cytokine Receptor-like Factor 2 and Janus Kinase 2 in Adult Acute Lymphoblastic Leukemia Open
AIM: The aim of the present study was to assess the diagnostic, prognostic, and predictive roles of the cytokine receptor-like factor 2 (CRLF2) and the Janus Kinase 2 (JAK2) genes expression in adult acute lymphoblastic leukemia (ALL) pati…
View article: The Prevalence and Prognostic Impacts of Nucleophosmin Mutations in Adult Patients with De Novo Acute Myeloid Leukemia
The Prevalence and Prognostic Impacts of Nucleophosmin Mutations in Adult Patients with De Novo Acute Myeloid Leukemia Open
BACKGROUND: Acute myeloid leukemia (AML) is known as cancer of the blood and bone marrow (BM) and is regarded as the commonest acute leukemia in adult patients. AIM: In this study, the aim to investigate the nucleophosmin mutations and the…
View article: RUNX1 gene expression in Egyptian acute myeloid leukemia patients: may it have therapeutic implications?
RUNX1 gene expression in Egyptian acute myeloid leukemia patients: may it have therapeutic implications? Open
Background Acute myeloid leukemia represents the highest percentage of all adult acute leukemia variants. Runt-related transcription factor1 ( RUNX1 ), a transcription factor with a known tumor suppressor function, was recently reported as…
View article: Micro-RNA Biogenesis Genes (AGO1 and GEMIN4) Single Nucleotide Variants of Bad Prognosis and Poor Therapeutic Response in Egyptian Chronic Myeloid Leukemia Patients: Case–control Study
Micro-RNA Biogenesis Genes (AGO1 and GEMIN4) Single Nucleotide Variants of Bad Prognosis and Poor Therapeutic Response in Egyptian Chronic Myeloid Leukemia Patients: Case–control Study Open
BACKGROUND: Chronic myeloid leukemia (CML) is one of the most common hematological tumors. Gene candidate studies cleared the association of single genetic variants (SNVs) to the risk and progression in CML. MicroRNA biogenesis genes disru…
View article: Fibroblast Growth Factor Receptor 4 Gly388Arg Gene Polymorphism and Non-Hodgkin Lymphoma Susceptibility and Prognosis in Egyptian population: Case–control Study
Fibroblast Growth Factor Receptor 4 Gly388Arg Gene Polymorphism and Non-Hodgkin Lymphoma Susceptibility and Prognosis in Egyptian population: Case–control Study Open
BACKGROUND: Angiogenesis is a multistep process having an essential role in the growth and progression of various tumors including hematolymphoid malignancies. Basic fibroblast growth factor (bFGF) is one of angiogenic growth factors which…
View article: Evaluation of prognostic variables in chronic lymphocytic leukemia and association with disease stage
Evaluation of prognostic variables in chronic lymphocytic leukemia and association with disease stage Open
The aim of the present study was to investigate different biological prognostic markers to identify high-risk patients with chronic lymphocytic leukemia (CLL) with a higher tumor burden, in order to ensure appropriate management. A total o…
View article: RUNX3 gene expression confers an independent Overall survival advantage in non-M3 adult acute myeloid leukemia patients in Egypt.
RUNX3 gene expression confers an independent Overall survival advantage in non-M3 adult acute myeloid leukemia patients in Egypt. Open
Pretreatment bone marrow samples from 46 newly diagnosed acute myeloid leukemia (AML) patients were analyzed by qRT-PCR. The aim of the present study was to evaluate mRNA expression of RUNX1,2 and 3 along with the hedgehog ligands Indian h…
View article: Clinical impact of early minimal residual disease detection at day 15 in precursor B-childhood acute lymphoblastic leukemia: an Egyptian experience
Clinical impact of early minimal residual disease detection at day 15 in precursor B-childhood acute lymphoblastic leukemia: an Egyptian experience Open
Background Chromosomal abnormalities in childhood acute lymphoblastic leukemia (ALL) are well-established prognostic markers and useful tools for minimal residual disease (MRD) assessment. This study aimed to stratify high-risk precursor B…
View article: <i>ITGA4</i> Gene Methylation Status in Chronic Lymphocytic Leukemia
<i>ITGA4</i> Gene Methylation Status in Chronic Lymphocytic Leukemia Open
Hypermethylation at ITGA4 gene CpG sites (1,2,3) is a characteristic feature in CLL.