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View article: ACUTE TOXICITY STUDIES OF Cirsium wallichii DC. AND Galium rotundifolium L. COLLECTED FROM THE HIGHLANDS OF KUMAUN HIMALAYAS (INDIA)
ACUTE TOXICITY STUDIES OF Cirsium wallichii DC. AND Galium rotundifolium L. COLLECTED FROM THE HIGHLANDS OF KUMAUN HIMALAYAS (INDIA) Open
A study was conducted to assess the acute toxicity profile of Galium rotundifolium and Cirsium wallichii used @ 2000 mg kg-1 body weight. These plants, traditionally used in Uttarakhand (India) for liver health, were evaluated for immediat…
View article: Invagination of Giant Unilamellar Vesicles upon Membrane Mixing with Native Vesicles
Invagination of Giant Unilamellar Vesicles upon Membrane Mixing with Native Vesicles Open
We demonstrate rapid membrane mixing between GUVs of pure lipid compositions and membrane vesicles (MVs) isolated from the plasma membrane of Vero cells, resulting in the transfer of native lipids and proteins to the GUVs. The steps involv…
View article: Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles
Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles Open
View article: Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles
Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles Open
Fluorescence lifetime imaging microscopy (FLIM) is a popular modality to create additional contrast in fluorescence images. By carefully analyzing pixel-based nanosecond lifetime patterns, FLIM allows studying complex molecular populations…
View article: Attachment of Virus to Host Cell Surface upon Specific Binding to Membrane Receptors and Attachment Factors
Attachment of Virus to Host Cell Surface upon Specific Binding to Membrane Receptors and Attachment Factors Open
Viruses are spherical particles of size 50–500 nm. The genome (DNA or RNA) of viruses is typically encapsulated by a protein shell, known as, capsid which is further coated by a protein-rich lipid bilayer for enveloped viruses. Most non-en…
View article: Effect of Imidacloprid and Chloropyrifos Toxicity on Earthworm Amynthas alexandri Under Laboratory Conditions
Effect of Imidacloprid and Chloropyrifos Toxicity on Earthworm Amynthas alexandri Under Laboratory Conditions Open
Aim: To highlight the impact of commonly used insecticides on earthworms as they represent the largest fraction of soil biomass. Earthworms were exposed to different concentrations of insecticides using a contact filter paper test method. …
View article: Membrane attachment and fusion of HIV-1, influenza A, and SARS-CoV-2: resolving the mechanisms with biophysical methods
Membrane attachment and fusion of HIV-1, influenza A, and SARS-CoV-2: resolving the mechanisms with biophysical methods Open
View article: Factors Affecting Honey Bee Population in Western Himalaya of Uttarakhand: An Observational Study
Factors Affecting Honey Bee Population in Western Himalaya of Uttarakhand: An Observational Study Open
Insect pollinators, especially honey bees, are an essential biotic factor in the reproductive success of plants that rely on insects for pollination. Their extinction would endanger food production and sustainable biodiversity. Climate cha…
View article: Two-dimensional Gel Analysis of Total Seed Protein of Horse Gram (Macrotyloma uniflorum) for Identification of their Proteomic Diversity
Two-dimensional Gel Analysis of Total Seed Protein of Horse Gram (Macrotyloma uniflorum) for Identification of their Proteomic Diversity Open
Horse gram (Macrotyloma uniflorum) is a popular pulse in the Kumaun region of Uttarakhand, locally known as Gahat dal and Kulti. An experiment was conducted with 5 horse gram cultivars having different grain colors. Total seed protein was …
View article: Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site
Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site Open
A longstanding question exists on the impact of the HIV-1 integration site on viral gene expression. This unsolved question has significant implications for the search toward an HIV-1 cure, as eradication strategies set up to reactivate an…
View article: Dissimilar Deformation of Fluid- and Gel-Phase Liposomes upon Multivalent Interaction with Cell Membrane Mimics Revealed Using Dual-Wavelength Surface Plasmon Resonance
Dissimilar Deformation of Fluid- and Gel-Phase Liposomes upon Multivalent Interaction with Cell Membrane Mimics Revealed Using Dual-Wavelength Surface Plasmon Resonance Open
The mechanical properties of biological nanoparticles play a crucial role in their interaction with the cellular membrane, in particular for cellular uptake. This has significant implications for the design of pharmaceutical carrier partic…
View article: Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context
Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context Open
View article: Experimental Evidence of Chloride‐Induced Trap Passivation in Lead Halide Perovskites through Single Particle Blinking Studies
Experimental Evidence of Chloride‐Induced Trap Passivation in Lead Halide Perovskites through Single Particle Blinking Studies Open
Research into organic–inorganic lead halide perovskites as photoactive material in solar cells and other electro‐optical devices has made immense progress in recent years. However, efficiency losses resulting from deep traps associated wit…
View article: Impurity-induced nematic–isotropic transition of liquid crystals
Impurity-induced nematic–isotropic transition of liquid crystals Open
Complex fluids made of liquid crystals and small molecules, surfactants, nanoparticles, or 1D/2D nanomaterials show novel and interesting features, making them suitable materials for various applications starting from optoelectronics to bi…
View article: A vaccine combination of lipid nanoparticles and a cholera toxin adjuvant derivative greatly improves lung protection against influenza virus infection
A vaccine combination of lipid nanoparticles and a cholera toxin adjuvant derivative greatly improves lung protection against influenza virus infection Open
View article: Entropy-driven impurity-induced nematic-isotropic transition of liquid\n crystals
Entropy-driven impurity-induced nematic-isotropic transition of liquid\n crystals Open
Phase behavior of liquid crystals is of long-standing interest due to\nnumerous applications, with one of the key issues being how the presence of\nimpurities affects the liquid crystalline order. Here we study the\norientational order of …
View article: Entropy-driven impurity-induced nematic-isotropic transition of liquid crystals
Entropy-driven impurity-induced nematic-isotropic transition of liquid crystals Open
Phase behavior of liquid crystals is of long-standing interest due to numerous applications, with one of the key issues being how the presence of impurities affects the liquid crystalline order. Here we study the orientational order of 4-c…
View article: Viscoelastic Properties of Polyelectrolyte Multilayers Swollen with Ionic Liquid Solutions
Viscoelastic Properties of Polyelectrolyte Multilayers Swollen with Ionic Liquid Solutions Open
Polyelectrolyte multilayers (PEM) obtained by layer-by-layer assembly can be doped with ionic liquid (IL) via the swelling of the films with IL solutions. In order to examine the mechanical properties of IL-containing PEM, we implement a K…
View article: Two-Phase Change in Thickness and Viscoelasticity of Polyelectrolyte\n Multilayers Swollen with Ionic Liquid Solution
Two-Phase Change in Thickness and Viscoelasticity of Polyelectrolyte\n Multilayers Swollen with Ionic Liquid Solution Open
Polyelectrolyte multilayers (PEM) in combination with good electrolyte\nsolvents, e.g., ionic liquids (ILs) are potential candidates for the new\ngeneration of electrochemical separators. Swelling PEM with aqueous IL\nsolutions is one way …
View article: Two-Phase Change in Thickness and Viscoelasticity of Polyelectrolyte Multilayers Swollen with Ionic Liquid Solution
Two-Phase Change in Thickness and Viscoelasticity of Polyelectrolyte Multilayers Swollen with Ionic Liquid Solution Open
Polyelectrolyte multilayers (PEM) in combination with good electrolyte solvents, e.g., ionic liquids (ILs) are potential candidates for the new generation of electrochemical separators. Swelling PEM with aqueous IL solutions is one way to …
View article: Single Viruses on the Fluorescence Microscope: Imaging Molecular Mobility, Interactions and Structure Sheds New Light on Viral Replication
Single Viruses on the Fluorescence Microscope: Imaging Molecular Mobility, Interactions and Structure Sheds New Light on Viral Replication Open
Viruses are simple agents exhibiting complex reproductive mechanisms. Decades of research have provided crucial basic insights, antiviral medication and moderately successful gene therapy trials. The most infectious viral particle is, howe…
View article: A Study on sleep quality index of male and female swimmers of Delhi (A comparative study)
A Study on sleep quality index of male and female swimmers of Delhi (A comparative study) Open
The investigator after a thorough study on the subject matter was motivated to undertake a study entitled “A Study on Sleep Quality Index of Male and Female Swimmers of Delhi. The objective of the Study was to compare between male and fema…
View article: Optimization of lipodisk properties by modification of the extent and density of the PEG corona
Optimization of lipodisk properties by modification of the extent and density of the PEG corona Open