Naheed Amir
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View article: α-Bisabolol, a Dietary Bioactive Terpene Attenuates Oxidative Stress and Inflammation in Colonic Mucosa of Acetic Acid-Induced Colitis in Rats
α-Bisabolol, a Dietary Bioactive Terpene Attenuates Oxidative Stress and Inflammation in Colonic Mucosa of Acetic Acid-Induced Colitis in Rats Open
Inflammatory bowel diseases (IBDs), such as ulcerative colitis, and Crohn’s disease are chronic idiopathic inflammatory diseases of the gastrointestinal system involving interaction between genetic and environmental factors mediating the o…
View article: Withania coagulans fruit extract antiulcerogenic effect: comparative study with lansoprazole and ranitidine in rats
Withania coagulans fruit extract antiulcerogenic effect: comparative study with lansoprazole and ranitidine in rats Open
Background Peptic ulcer disease (PUD) arises from an imbalance between harmful factors like gastric acid and pepsin, and the protective mechanisms of the gastrointestinal lining, particularly the mucus–bicarbonate barrier. Standard treatme…
View article: Novel Thiazolidinedione and Rhodanine Derivatives Regulate Glucose Metabolism, Improve Insulin Sensitivity, and Activate the Peroxisome Proliferator-Activated γ Receptor
Novel Thiazolidinedione and Rhodanine Derivatives Regulate Glucose Metabolism, Improve Insulin Sensitivity, and Activate the Peroxisome Proliferator-Activated γ Receptor Open
Sixteen novel thiazolidinedione (TZD) and rhodanine (RD) derivatives were designed and synthesized by introducing a pyrimidine moiety at different sites of pioglitazone's structure. The effects of synthesized compounds on regulating glucos…
View article: Effects of long-term dehydration on stress markers, blood parameters, and tissue morphology in the dromedary camel (Camelus dromedarius)
Effects of long-term dehydration on stress markers, blood parameters, and tissue morphology in the dromedary camel (Camelus dromedarius) Open
Introduction Dromedary camels robustly withstand dehydration, and the rough desert environment but the adaptation mechanisms are not well understood. One of these mechanisms is that the dromedary camel increases its body temperature to red…
View article: Stereological Evidence of Non-Selective Hippocampal Neurodegeneration, IGF-1 Depletion, and Behavioral Deficit following Short Term Bilateral Adrenalectomy in Wistar Rats
Stereological Evidence of Non-Selective Hippocampal Neurodegeneration, IGF-1 Depletion, and Behavioral Deficit following Short Term Bilateral Adrenalectomy in Wistar Rats Open
The development of animal models to study cell death in the brain is a delicate task. One of the models, that was discovered in the late eighties, is the induction of neurodegeneration through glucocorticoid withdrawal by adrenalectomy in …
View article: Lycopodium Mitigates Oxidative Stress and Inflammation in the Colonic Mucosa of Acetic Acid-Induced Colitis in Rats
Lycopodium Mitigates Oxidative Stress and Inflammation in the Colonic Mucosa of Acetic Acid-Induced Colitis in Rats Open
Inflammatory bowel diseases (IBDs) such as ulcerative colitis (UC) and Crohn’s disease (CD) are diseases of the gastrointestinal system involving genetic and environmental factors attributed to oxidative stress and inflammation. Targeting …
View article: Stereological Evidence of Non-Selective Hippocampal Neurodegeneration, Growth Factors Depletion, and Behavioral Deficit Following Short-Term Bilateral Adrenalectomy in Wistar Rats 
Stereological Evidence of Non-Selective Hippocampal Neurodegeneration, Growth Factors Depletion, and Behavioral Deficit Following Short-Term Bilateral Adrenalectomy in Wistar Rats Open
In the current study we investigated the impact of short-term adrenalectomy on hippocampal neurons of Wistar rats. In addition, the underlying mechanism(s) of degeneration in these neurons was investigated by measuring the levels of insuli…
View article: Effects of Long-Term Dehydration on Growth Factors, Oxidative Stress and Neuroinflammation in the Hippocampus of the Arabian Camel (Camelus dromedarius)
Effects of Long-Term Dehydration on Growth Factors, Oxidative Stress and Neuroinflammation in the Hippocampus of the Arabian Camel (Camelus dromedarius) Open
The Camels can tolerate loss of water corresponding to 30% of their body weight,
View article: Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model
Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model Open
Physiological Glucocorticoids are important regulators of the immune system. Pharmacological GCs are in widespread use to treat inflammatory diseases. Adrenalectomy (ADX) has been shown to exacerbate renal injury through inflammation and o…
View article: Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier
Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier Open
This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8. The prepared pyrimidine GLP-1 agonist used for the treatment of diabetes type…
View article: Targeting PPAR<i>γ</i> Receptor Using New Phosphazene Derivative Containing Thiazolidinedione: Design, Synthesis, and Glucose Uptake
Targeting PPAR<i>γ</i> Receptor Using New Phosphazene Derivative Containing Thiazolidinedione: Design, Synthesis, and Glucose Uptake Open
The peroxisome proliferator activator receptor-γ (PPAR-γ) remained the most effective target for management of diabetes mellitus. The present work endeavors rational designing new PPAR-γ agonist bearing cyclotriphosphazene and thiazolidine…
View article: Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha-Methylhistamine in C57BL/6 Mice
Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha-Methylhistamine in C57BL/6 Mice Open
The role of histamine H3 receptors (H3Rs) in the regulation of gastroprotection and production of prostaglandin E2 (PGE2) as well as somatostatin remains contradictory. Therefore, the effects of the H3R antagonist/inverse agonist M39 on in…
View article: Menthol inhibits oxidative stress and inflammation in acetic acid-induced colitis in rat colonic mucosa.
Menthol inhibits oxidative stress and inflammation in acetic acid-induced colitis in rat colonic mucosa. Open
Inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease are characterized by chronic inflammation of the gastrointestinal system. There is no permanent cure from IBD except constant medication or surgery to keep th…
View article: Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis
Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis Open
Cytochrome P450 1A2 (CYP1A2) is one of the CYP450 mixed-function oxidase system that is of clinical importance due to the large number of drug interactions associated with its induction and inhibition. In addition, significant inter-indivi…
View article: Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy
Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy Open
Our study showed an early increase in the pro-inflammatory cytokines followed by neurodegeneration and activation of glial cells as well as oxidative stress. Taking these findings together it could be speculated that the early inflammatory…
View article: Hippocampal Neuroinflammation, Neurodegeneration, Gliosis in Wistar rats Following Adrenal Gland Removal.
Hippocampal Neuroinflammation, Neurodegeneration, Gliosis in Wistar rats Following Adrenal Gland Removal. Open
Event Abstract Back to Event Hippocampal Neuroinflammation, Neurodegeneration, Gliosis in Wistar rats Following Adrenal Gland Removal. Naserddine Hamadi1, 2, Abdu Adem1*, Fatima Khelifi-touhami2, Azim Ullah Shamsulislam Sheikh1, Naheed Ami…