Nahéma Issa
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View article: Response to “high-flow nasal cannula and intubation risk in severe PjP: methodological and clinical perspectives”
Response to “high-flow nasal cannula and intubation risk in severe PjP: methodological and clinical perspectives” Open
View article: Social Precariousness and the Outcome of Critical Illnesses in People with HIV: A Multicenter Cohort Study
Social Precariousness and the Outcome of Critical Illnesses in People with HIV: A Multicenter Cohort Study Open
Background Social precariousness hinders access to the cascade of care in people with HIV (PHIV). Its impact on the clinical presentation and outcome of critical illnesses in this patient population is unknown. Methods We included all PHIV…
View article: COVID-19 convalescent plasma for B-cell depleted patients: a systematic review and individual patient data meta-analysis
COVID-19 convalescent plasma for B-cell depleted patients: a systematic review and individual patient data meta-analysis Open
COVID-19 convalescent plasma (CCP) obtained from recently recovered people is safe and effective against SARS-CoV-2. Currently available CCP is a “hybrid” product with antibodies from individuals who had both infection and vaccination (vac…
View article: Endogenous endophthalmitis complicating infective endocarditis: a multicentre case-matched control cohort
Endogenous endophthalmitis complicating infective endocarditis: a multicentre case-matched control cohort Open
Aims Endogenous endophthalmitis (EE) is a rarely reported complication of infective endocarditis (IE). In an international series, we sought to determine the clinical and microbiological profile, treatment, and outcome of patients presenti…
View article: Respiratory management of critically ill pneumocystis pneumonia patients: a multicenter retrospective study
Respiratory management of critically ill pneumocystis pneumonia patients: a multicenter retrospective study Open
Background Pneumocystis jirovecii pneumonia (PjP) is a rising cause of acute respiratory failure in immunocompromised patients, often requiring Intensive Care Unit (ICU) admission. However, optimal ventilatory strategies remain unclear. Me…
View article: Critical care illness in allogeneic hematopoietic stem-cell transplantation recipients with chronic graft versus host disease
Critical care illness in allogeneic hematopoietic stem-cell transplantation recipients with chronic graft versus host disease Open
View article: Immune checkpoint inhibitor-associated myocarditis: a novel risk score
Immune checkpoint inhibitor-associated myocarditis: a novel risk score Open
Background and Aims Immune checkpoint inhibitors (ICI) are associated with life-threatening myocarditis but milder presentations are increasingly recognized. The same autoimmune process that causes ICI myocarditis can manifest concurrent g…
View article: Convalescent plasma treatment of B-cell depleted patients with COVID-19: systematic review and individual participant data meta-analysis
Convalescent plasma treatment of B-cell depleted patients with COVID-19: systematic review and individual participant data meta-analysis Open
Background COVID-19 convalescent plasma (CCP) is obtained from people recently recovered from COVID-19 and contains viral-neutralizing antibodies. Because such treatment is safe and effective against SARS-CoV-2, the US Food and Drug Admini…
View article: Design and Installation of a Solar and Wind Hybrid System in Kano State, Nigeria
Design and Installation of a Solar and Wind Hybrid System in Kano State, Nigeria Open
This project aims to design and install a hybrid power system that combines two renewable energy sources, namely solar and wind energy, to produce reliable and sustainable electricity. Three solar panels and a wind turbine were installed i…
View article: Prognosis of liver abscess in the intensive care unit (POLAIR), a multicentre observational study
Prognosis of liver abscess in the intensive care unit (POLAIR), a multicentre observational study Open
This multicentre study illustrates the severity of LA in French intensive care units and identifies organ dysfunction (SOFA score) and portal vein thrombosis as major risk factors for mortality. Prospective studies are needed to improve ma…
View article: Immune Checkpoint Inhibitor Myocarditis and Left Ventricular Systolic Dysfunction
Immune Checkpoint Inhibitor Myocarditis and Left Ventricular Systolic Dysfunction Open
Dyspnea, time from ICI initiation, a history of heart failure, and prior cardiotoxic therapy may be predictors of an initial LVEF <50% in patients with ICI-M.
View article: Real-world evidence of dalbavancin effectiveness as consolidation therapy in infective endocarditis due to Enterococcus spp.
Real-world evidence of dalbavancin effectiveness as consolidation therapy in infective endocarditis due to Enterococcus spp. Open
DBV appears to be highly effective, safe, and cost-effective as consolidation therapy in patients with IE caused by Enterococcus spp., with minimal adverse events.
View article: Antibiotic therapy and prophylaxis of infective endocarditis – A SPILF-AEPEI position statement on the ESC 2023 guidelines
Antibiotic therapy and prophylaxis of infective endocarditis – A SPILF-AEPEI position statement on the ESC 2023 guidelines Open
View article: Clinical characteristics and outcomes of immunocompromised critically ill patients with cytomegalovirus end-organ disease: a multicenter retrospective cohort study
Clinical characteristics and outcomes of immunocompromised critically ill patients with cytomegalovirus end-organ disease: a multicenter retrospective cohort study Open
Background Cytomegalovirus (CMV) infection in patients with cellular immune deficiencies is associated with significant morbidity and mortality. However, data on CMV end-organ disease (CMV-EOD) in critically ill, immunocompromised patients…
View article: Safety of immune checkpoint inhibitor rechallenge after severe immune-related adverse events: a retrospective analysis
Safety of immune checkpoint inhibitor rechallenge after severe immune-related adverse events: a retrospective analysis Open
Immune checkpoint inhibitors (ICIs) present clinicians with the challenge of managing immune-related adverse events (irAEs), which can range from mild to severe due to immune system activation 1 . While guidelines recommend discontinuing I…
View article: Predictors and Risk Score for Immune Checkpoint-Inhibitor-Associated Myocarditis Severity
Predictors and Risk Score for Immune Checkpoint-Inhibitor-Associated Myocarditis Severity Open
Background: Immune-checkpoint inhibitors (ICI) are associated with life-threatening myocarditis but milder presentations are increasingly recognized. The same autoimmune process that causes ICI-myocarditis can manifest concurrent generaliz…
View article: Convalescent plasma transfusion for immunocompromised viremic patients with COVID‐19: A retrospective multicenter study
Convalescent plasma transfusion for immunocompromised viremic patients with COVID‐19: A retrospective multicenter study Open
This study aims to assess the safety, virological, and clinical outcomes of convalescent plasma transfusion (CPT) in immunocompromised patients hospitalized for coronavirus disease 2019 (COVID‐19). We conducted a retrospective multicenter …
View article: Correction: Clinical spectrum and prognostic impact of cancer in critically ill patients with HIV: a multicentre cohort study
Correction: Clinical spectrum and prognostic impact of cancer in critically ill patients with HIV: a multicentre cohort study Open
View article: Critically Ill Patients with Visceral <i>Nocardia</i> Infection, France and Belgium, 2004–2023
Critically Ill Patients with Visceral <i>Nocardia</i> Infection, France and Belgium, 2004–2023 Open
We studied 50 patients with invasive nocardiosis treated during 2004-2023 in intensive care centers in France and Belgium. Most (65%) died in the intensive care unit or in the year after admission. Nocardia infections should be included in…
View article: Multicenter Retrospective Study of Invasive Fusariosis in Intensive Care Units, France
Multicenter Retrospective Study of Invasive Fusariosis in Intensive Care Units, France Open
Invasive fusariosis can be life-threatening, especially in immunocompromised patients who require intensive care unit (ICU) admission. We conducted a multicenter retrospective study to describe clinical and biologic characteristics, patien…
View article: Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease
Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease Open
View article: Publisher Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis
Publisher Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis Open
View article: Author Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis
Author Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis Open
View article: Outcomes of targeted treatment in immunocompromised patients with asymptomatic or mild COVID-19: a retrospective study
Outcomes of targeted treatment in immunocompromised patients with asymptomatic or mild COVID-19: a retrospective study Open
The aim of this study was to describe the outcomes of targeted COVID-19 treatments in immunocompromised patients with asymptomatic or mild COVID-19 during the period of expansion of the different Omicron subvariants in France. A retrospect…
View article: Clinical spectrum and prognostic impact of cancer in critically ill patients with HIV: a multicentre cohort study
Clinical spectrum and prognostic impact of cancer in critically ill patients with HIV: a multicentre cohort study Open
View article: Prognosis of immune checkpoint inhibitors-induced myocarditis: a case series
Prognosis of immune checkpoint inhibitors-induced myocarditis: a case series Open
Background Immune checkpoint inhibitors (ICI) have transformed cancer treatment over the last decade. Alongside this therapeutic improvement, a new variety of side effects has emerged, called immune-related adverse events (irAEs), potentia…
View article: Necrotizing soft tissue infections in critically ill neutropenic patients: a French multicentre retrospective cohort study
Necrotizing soft tissue infections in critically ill neutropenic patients: a French multicentre retrospective cohort study Open
Background Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections. Few data are available regarding neutropenic patients with NSTIs. Our objectives were to describe the characteristics and management of n…
View article: Outcomes in Critically-Ill Allogeneic Hematopoietic Stem-Cell Transplantation Recipients: A Groupe De Recherche Respiratoire En ReAnimation Onco-HeMatologique (GRRR-OH) Study
Outcomes in Critically-Ill Allogeneic Hematopoietic Stem-Cell Transplantation Recipients: A Groupe De Recherche Respiratoire En ReAnimation Onco-HeMatologique (GRRR-OH) Study Open
View article: Interest of a Commercialized Pneumocystis jirovecii Quantitative PCR to Discriminate Colonization from Pneumocystis Pneumonia according to the Revised EORTC/MSGERC Criteria
Interest of a Commercialized Pneumocystis jirovecii Quantitative PCR to Discriminate Colonization from Pneumocystis Pneumonia according to the Revised EORTC/MSGERC Criteria Open
Quantitative PCR (qPCR) is highly sensitive to diagnose Pneumocystis jirovecii (Pj) pneumonia (PCP). However, differentiating PCP and colonization remains difficult. This study aimed to establish the performances of the commercialized qPCR…
View article: A Multiplex PCR and DNA-Sequencing Workflow on Serum for the Diagnosis and Species Identification for Invasive Aspergillosis and Mucormycosis
A Multiplex PCR and DNA-Sequencing Workflow on Serum for the Diagnosis and Species Identification for Invasive Aspergillosis and Mucormycosis Open
There has been significant increase in the use of molecular tools for the diagnosis of invasive aspergillosis (IA) and mucormycosis. However, their range of detection may be too limited as species diversity and coinfections are increasing.