Nahla Ayoub
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View article: Botulinum Toxin Therapy: A Comprehensive Review on Clinical and Pharmacological Insights
Botulinum Toxin Therapy: A Comprehensive Review on Clinical and Pharmacological Insights Open
Background: Botulinum toxin (BoNT), produced by Clostridium botulinum, has transitioned from being a lethal neurotoxin to a versatile therapeutic agent. Its ability to inhibit neurotransmitter release by targeting Soluble N-ethylmaleimide-…
View article: Abnormalities in Blood Parameters in Athletes Taking Anabolic Androgenic Steroidal Agents; an Observational Clinical Study
Abnormalities in Blood Parameters in Athletes Taking Anabolic Androgenic Steroidal Agents; an Observational Clinical Study Open
The unsupervised use of AAS alone or in combination with other hormones and/or supplements may lead to adverse effects. Further studies with larger samples are needed to draw significant conclusions about the safety of using AAS.
View article: A cross-sectional study comparing the use of e-cigarettes and traditional tobacco cigarettes among young Makkah people
A cross-sectional study comparing the use of e-cigarettes and traditional tobacco cigarettes among young Makkah people Open
Background and Aims: Tobacco smoking has a significant role in health deterioration worldwide. The study was conducted to estimate the prevalence and awareness of smoking among young Makkah people. Methods: A cross-sectional study was cond…
View article: Knowledge, attitude and practice among mothers on the relationship between honey and botulism in Saudi Arabian infants: a cross-section study
Knowledge, attitude and practice among mothers on the relationship between honey and botulism in Saudi Arabian infants: a cross-section study Open
The study revealed that mothers from Hail city have relatively low knowledge of IB and that they hold favourable perceptions of using honey as a food supplement and feeding honey to their infants before 12 months. Considering the high prev…
View article: Computer-Assisted HPLC Method Development Using DryLab for Determination of Major Phenolic Components in Corchorus olitorius and Vitis vinifera by using HPLC-PDA-ESI-TOF- MSn
Computer-Assisted HPLC Method Development Using DryLab for Determination of Major Phenolic Components in Corchorus olitorius and Vitis vinifera by using HPLC-PDA-ESI-TOF- MSn Open
Computer–assisted HPLC method development is a tool that uses Design-ofExperiment techniques to optimize HPLC methods with minimal time and cost, especially for complex mixtures like natural extracts. Corchorus olitorius and Vitis vinifera…
View article: Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia
Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia Open
Methanol poisoning is a challenging issue due to its inducing acute multiple organ failures, and especially due to a lack of preparedness, available antidotes, and management protocols. The current study presents six cases of methanol pois…
View article: Risk of Polypharmacy and Its Outcome in Terms of Drug Interaction in an Elderly Population: A Retrospective Cross-Sectional Study
Risk of Polypharmacy and Its Outcome in Terms of Drug Interaction in an Elderly Population: A Retrospective Cross-Sectional Study Open
The simultaneous use of multiple drugs—termed ‘polypharmacy’—is often required to manage multiple physiological and biological changes and the interplay between chronic disorders that are expected to increase in association with ageing. Ho…
View article: Polypharmacy among patients with hypertension attending primary healthcare centres
Polypharmacy among patients with hypertension attending primary healthcare centres Open
Introduction: Saudi Arabia has several hypertensive patients who require close attention and specialised care for their medications. Polypharmacy is one of the reasons for the failure of patient compliance with antihypertensive medications…
View article: Patterns of acute poisoning for children during outbreak of Corona virus in Makkah region Saudi Arabia
Patterns of acute poisoning for children during outbreak of Corona virus in Makkah region Saudi Arabia Open
Background Poisoning occurs when a person is exposed to an external substance at a too high dose for them. It is possible for young children to be exposed to chemicals. Lungs, the heart, CNS, the digestive tract, and kidneys can be poisone…
View article: Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study
Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study Open
(1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibi…
View article: Over-the-Counter Medication Use among Parents in Saudi Arabia
Over-the-Counter Medication Use among Parents in Saudi Arabia Open
Introduction: Self-medication is a growing public health concern worldwide. Studies have shown a gap between best practice and the current practice of using over-the-counter (OTC) medications. Despite being a well-recognised problem in Sau…
View article: The use of the nutritional supplements during the covid-19 outbreak in Saudi Arabia: A cross-sectional study
The use of the nutritional supplements during the covid-19 outbreak in Saudi Arabia: A cross-sectional study Open
BACKGROUND: COVID-19 causes moderate to severe illness and is spreading globally. During a pandemic, vitamins and minerals are vital to health. Therefore, the prevalence and epidemiology of supplement use in Saudi Arabia during the COVID-1…
View article: Reported Cases of Alcohol Consumption and Poisoning for the Years 2015 to 2022 in Hail, Saudi Arabia
Reported Cases of Alcohol Consumption and Poisoning for the Years 2015 to 2022 in Hail, Saudi Arabia Open
This study aimed to determine the pattern of alcohol consumption and its poisoning among the Saudi population in the city of Hail, KSA. Data from a retrospective cohort were collected qualitatively at King Khalid Hospital (KKH) and Hail Ge…
View article: Efficacy and Safety of Empagliflozin in Type 2 Diabetes Mellitus Saudi Patients as Add-On to Antidiabetic Therapy: A Prospective, Open-Label, Observational Study
Efficacy and Safety of Empagliflozin in Type 2 Diabetes Mellitus Saudi Patients as Add-On to Antidiabetic Therapy: A Prospective, Open-Label, Observational Study Open
The Saudi Food and Drug Authority (SFDA) approved sodium-glucose cotransporter-2 (SGLT2) inhibitors in 2018. The efficacy and safety of empagliflozin (EMPA) have been confirmed in the U.S., Europe, and Japan for patients with type 2 diabet…
View article: Medication Adherence among Patients with Chronic Diseases in Saudi Arabia
Medication Adherence among Patients with Chronic Diseases in Saudi Arabia Open
Introduction: The management of chronic illnesses commonly includes a long-term pharmacological approach. Although these medications effectively control disease, their full benefits are often not realized because approximately 50% of patie…
View article: Patterns of Caffeine Consumption in Western Province of Saudi Arabia
Patterns of Caffeine Consumption in Western Province of Saudi Arabia Open
Pharmacognosy Research,2022,14,3,269-275.DOI:10.5530/pres.14.3.39Published:July 2022Type:Original ArticleAuthors:Reem A Radwan, Hassan H Alwafi, Yosra Z Alhindi, Alaa H Falemban, Shakeel A Ansari, Asim M Alshanberi, Nahla A Ayoub, and Safa…
View article: Knowledge, Attitude, and Practice of Bee Venom Acupuncture Therapy on Rheumatoid Arthritis Among Patients in Saudi Arabia
Knowledge, Attitude, and Practice of Bee Venom Acupuncture Therapy on Rheumatoid Arthritis Among Patients in Saudi Arabia Open
Shahd E Sharaf,1,2 Safaa Alsanosi,1 Abdullah R Alzahrani,1,2 Saeed S Al-Ghamdi,1,2 Sharaf E Sharaf,2– 4 Nahla Ayoub1,2 1Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 2Saudi To…
View article: GC/MS Profiling and Ex Vivo Antibacterial Activity of Salvadora persica (Siwak) against Enterococcus faecalis as Intracanal Medicament
GC/MS Profiling and Ex Vivo Antibacterial Activity of Salvadora persica (Siwak) against Enterococcus faecalis as Intracanal Medicament Open
Introduction. Salvadora persica L. (S. persica, Siwak) has been used for many centuries as oral hygiene tools, particularly in Saudi Arabia. This study aimed to assess the effectiveness of S. persica petroleum ether extract (SPE) as an int…
View article: HPLC/MSn Profiling and Healing Activity of a Muco-Adhesive Formula of Salvadora persica against Acetic Acid-Induced Oral Ulcer in Rats
HPLC/MSn Profiling and Healing Activity of a Muco-Adhesive Formula of Salvadora persica against Acetic Acid-Induced Oral Ulcer in Rats Open
Salvadora persica L. (S. persica, Siwak) is an ethnic plant that is widely used for improving oral hygiene. This study aimed to provide a phytochemical profiling of S. persica ethyl acetate fraction (SPEAF) and to evaluate the healing acti…
View article: Drug Therapies Affecting Renal Function: An Overview
Drug Therapies Affecting Renal Function: An Overview Open
Undesirable side effects of medication are inevitable. Due to the role of the kidneys in clearance and filtration, the renal system faces a unique situation when it comes to the side effects of drugs. It has an important role for different…
View article: The Effectiveness of Salavadora Persica (Siwak) Petroleum Ether Extract As An Intracanal Medicament Used in Endodontic Therapy: An In Vitro Study
The Effectiveness of Salavadora Persica (Siwak) Petroleum Ether Extract As An Intracanal Medicament Used in Endodontic Therapy: An In Vitro Study Open
Background: Salvadora persica L . (Siwak) of the family Salvadoraceae has been used for many centuries as oral hygiene tools, particularly in Saudi Arabia. The current study aimed at developing a new root canal medicament based on the extr…
View article: Anti-inflammatory and antimicrobial activities of the successive extracts of the aerial parts of <i /><i>Rumex pictus </i><i />Forssk. growing in Egypt<b />
Anti-inflammatory and antimicrobial activities of the successive extracts of the aerial parts of <i><i>Rumex pictus </i><i>Forssk. growing in Egypt<b> Open
Introduction: Rumex spp. have been used in folk medicine either as food or as medicine for the treatment of several diseases including constipation, fever, inflammation, bacterial and fungal infections. This study aimed to evaluate the ant…
View article: Aldose reductase inhibitor form Cassia glauca: A comparative study of cytotoxic activity with Ag nanoparticles (NPs) and molecular docking evaluation
Aldose reductase inhibitor form Cassia glauca: A comparative study of cytotoxic activity with Ag nanoparticles (NPs) and molecular docking evaluation Open
UPLC-MS/MS profiling of Cassia glauca leaves extract revealed the identification of 10 flavonoids. Kaempferol 3-O-β-D-rutinoside was isolated and studied for its cytotoxic activity. It showed high cytotoxic effects against MCF-7 (IC50 of 4…
View article: Chemical Constituents and Biological Activities of Cassia Genus: Review
Chemical Constituents and Biological Activities of Cassia Genus: Review Open
A review of chemical constituents and pharmacological activities of genus Cassia, Family Leguminosae has been presented. There are about 600 species of this genus distributed all around the world. Many of these species are still not invest…
View article: Biological and phytochemical review on the genus Coccoloba (Polygonaceae)
Biological and phytochemical review on the genus Coccoloba (Polygonaceae) Open
Polygonaceae is one of the largest medicinal plant families, vastly distributed worldwide, containing around 1,200 species from 48 genera. Most of the species are located in the northern temperate region, while the other species are alloca…
View article: ISOLATION OF BIOACTIVE COMPOUNDS FROM CENTAUREA AEGYPTIACA
ISOLATION OF BIOACTIVE COMPOUNDS FROM CENTAUREA AEGYPTIACA Open
Objective: In a previous study, Centaurea aegyptiaca ethanol and ethyl acetate extracts showed potent cytotoxic effects against laryngeal (HEP2) and hepatic (HEPG2) carcinoma cell lines. Additionally, two novel compounds were isolated and …
View article: Hepatoprotective activity of aerial parts of Erythrina crista-galli
Hepatoprotective activity of aerial parts of Erythrina crista-galli Open
Hepatoprotective activity was measured for Erythrina crista-galli extract as well as fractions. Fractions II and III have shown a remarkable protective effect against CCl4-induced hepatocyte injury. This was evidenced by their ability to s…