NaHye Lee
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View article: Comparing the efficacy of combined versus single immune cell adaptive therapy targeting colorectal cancer
Comparing the efficacy of combined versus single immune cell adaptive therapy targeting colorectal cancer Open
Purpose: Colorectal cancer (CRC) is the most frequent cancer with limited therapeutic achievements. Recently, adoptive cellular immunotherapy has been developed as an antitumor therapy. However, its efficacy has not been tested in CRC. Thi…
View article: The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages
The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages Open
Significance Expression and function of odorant receptors (ORs) are being increasingly reported in nonolfactory sites. However, ORs that can be targeted by drugs to treat diseases remain poorly identified. Here, we hypothesized that the ma…
View article: Interhemispheric asymmetry of c‐Fos expression in glomeruli and the olfactory tubercle following repeated odor stimulation
Interhemispheric asymmetry of c‐Fos expression in glomeruli and the olfactory tubercle following repeated odor stimulation Open
Odor adaptation allows the olfactory system to regulate sensitivity to different stimulus intensities, which is essential for preventing saturation of the cell‐transducing machinery and maintaining high sensitivity to persistent and repeti…
View article: A pathogen‐derived metabolite induces microglial activation via odorant receptors
A pathogen‐derived metabolite induces microglial activation via odorant receptors Open
Microglia (MG), the principal neuroimmune sentinels in the brain, continuously sense changes in their environment and respond to invading pathogens, toxins, and cellular debris, thereby affecting neuroinflammation. Microbial pathogens prod…
View article: MRPrimer: a MapReduce-based method for the thorough design of valid and ranked primers for PCR
MRPrimer: a MapReduce-based method for the thorough design of valid and ranked primers for PCR Open
Primer design is a fundamental technique that is widely used for polymerase chain reaction (PCR). Although many methods have been proposed for primer design, they require a great deal of manual effort to generate feasible and valid primers…
View article: Olfactory Marker Protein Expression Is an Indicator of Olfactory Receptor-Associated Events in Non-Olfactory Tissues
Olfactory Marker Protein Expression Is an Indicator of Olfactory Receptor-Associated Events in Non-Olfactory Tissues Open
Olfactory receptor (OR)-associated events are mediated by well-conserved components in the olfactory epithelium, including olfactory G-protein (Golf), adenylate cyclase III (ACIII), and olfactory marker protein (OMP). The expression of ORs…