Naia Risager Wright
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View article: Emergence of phenotypically distinct subpopulations is a factor in adaptation of recombinant Saccharomyces cerevisiae under glucose-limited conditions
Emergence of phenotypically distinct subpopulations is a factor in adaptation of recombinant Saccharomyces cerevisiae under glucose-limited conditions Open
Cells cultured in a nutrient-limited environment can undergo adaptation, which confers improved fitness under long-term energy limitation. We have previously shown how a recombinant S. cerevisiae strain, producing a heterologous insulin pr…
View article: Emergence of Phenotypically Distinct Subpopulations Is a Factor in Adaptation of Recombinant Saccharomyces cerevisiae under Glucose-Limited Conditions
Emergence of Phenotypically Distinct Subpopulations Is a Factor in Adaptation of Recombinant Saccharomyces cerevisiae under Glucose-Limited Conditions Open
The yeast Saccharomyces cerevisiae is an attractive microbial host for industrial production and is used widely for manufacturing, e.g., pharmaceuticals. Chemostat cultivation mode is an efficient cultivation strategy for industrial produc…
Emergence of phenotypically distinct subpopulations is a factor in adaptation of recombinant <i>Saccharomyces cerevisiae</i> under glucose-limited conditions Open
Cells cultured in a nutrient-limited environment can undergo adaptation, which confers improved fitness under long-term energy limitation. We have previously shown how a recombinant S. cerevisiae strain, producing a heterologous insulin pr…
Single-Cell Technologies to Understand the Mechanisms of Cellular Adaptation in Chemostats Open
There is a growing interest in continuous manufacturing within the bioprocessing community. In this context, the chemostat process is an important unit operation. The current application of chemostat processes in industry is limited althou…
CRISPR interference of nucleotide biosynthesis improves production of a single‐domain antibody in <i>Escherichia coli</i> Open
Growth decoupling can be used to optimize the production of biochemicals and proteins in cell factories. Inhibition of excess biomass formation allows for carbon to be utilized efficiently for product formation instead of growth, resulting…
CRISPR interference of nucleotide biosynthesis improves production of a single-domain antibody Open
Growth decoupling can be used to optimize production of biochemicals and proteins in cell factories. Inhibition of excess biomass formation allows for carbon to be utilized efficiently for product formation instead of growth, resulting in …
Fluctuations in glucose availability prevent global proteome changes and physiological transition during prolonged chemostat cultivations of <i>Saccharomyces cerevisiae</i> Open
Chemostat cultivation mode imposes selective pressure on the cells, which may result in slow adaptation in the physiological state over time. We applied a two‐compartment scale‐down chemostat system imposing feast–famine conditions to char…