Naiem T. Issa
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View article: Current Topical Treatment Approaches for Managing Acne Associated with Janus Kinase Inhibitors
Current Topical Treatment Approaches for Managing Acne Associated with Janus Kinase Inhibitors Open
Introduction: Acne is increasingly recognized as an adverse event associated with JAKi (“JAKne”), with 2 meta-analyses demonstrating increased acne risk with JAKi. Initially developed for autoimmune/inflammatory conditions, JAKi indication…
View article: Anchored Matching-Adjusted Indirect Comparison of the Long-Term Maintenance of Efficacy of Tralokinumab and Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis
Anchored Matching-Adjusted Indirect Comparison of the Long-Term Maintenance of Efficacy of Tralokinumab and Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis Open
Comparable maintenance of efficacy was observed between tralokinumab and lebrikizumab after 52 weeks of treatment among patients meeting response criteria at week 16.
View article: The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release
The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release Open
View article: Structural Insights: What Makes Some PDE4 Inhibitors More Effective in Inflammatory Dermatoses.
Structural Insights: What Makes Some PDE4 Inhibitors More Effective in Inflammatory Dermatoses. Open
Psoriasis, seborrheic dermatitis, and atopic dermatitis are chronic inflammatory skin diseases affecting millions of people in the United States and worldwide across the human lifespan. The immune pathways underlying the pathogenesis of th…
View article: The Epidemiology of Atopic Dermatitis among Adults and Adolescents with Alopecia Areata in the United States
The Epidemiology of Atopic Dermatitis among Adults and Adolescents with Alopecia Areata in the United States Open
This study evaluated the prevalence, incidence, and relative risk of comorbid atopic dermatitis (AD) among patients with alopecia areata (AA) using data from the Merative MarketScan Research Databases. Eligible patients had ≥1 inpatient or…
View article: Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling
Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling Open
View article: Bimekizumab Maintenance of Response at Every Visit Over 4 Years in Patients with Psoriasis Achieving Clear Skin at Week 16: Results from Four Phase 3 Trials
Bimekizumab Maintenance of Response at Every Visit Over 4 Years in Patients with Psoriasis Achieving Clear Skin at Week 16: Results from Four Phase 3 Trials Open
Introduction: Achieving and maintaining skin clearance is key for patients with psoriasis.1,2 However, loss of disease control over time is often seen with biologics; therefore, evaluating whether high efficacy levels are maintained at eve…
View article: A Review of Glucagon-like Peptide-1 in Dermatology.
A Review of Glucagon-like Peptide-1 in Dermatology. Open
The literature suggests anti-inflammatory effects of GLP-1RAs may provide direct benefit in the treatment of dermatologic conditions independent of glucose control in addition to indirect improvement via modulation of blood glucose and wei…
View article: Recommendations to Improve Outcomes in Acne and Acne Sequelae: A Focus on Trifarotene and Other Retinoids
Recommendations to Improve Outcomes in Acne and Acne Sequelae: A Focus on Trifarotene and Other Retinoids Open
View article: Achievement of Optimal Treatment Targets with Oral Janus Kinase Inhibition in Elderly Patients with Atopic Dermatitis: A Real-world, Multicenter, Retrospective Study.
Achievement of Optimal Treatment Targets with Oral Janus Kinase Inhibition in Elderly Patients with Atopic Dermatitis: A Real-world, Multicenter, Retrospective Study. Open
We demonstrate the ability to achieve optimal treatment targets and safety of selective JAKi-1 inhibitors in elderly patients with AD.
View article: Investigating Efficacy of Atopic Dermatitis Systemic Therapeutics After Discontinuation Part I: Biologics.
Investigating Efficacy of Atopic Dermatitis Systemic Therapeutics After Discontinuation Part I: Biologics. Open
The variability in eligibility criteria, treatment durations, and withdrawal periods across trials presents a major challenge in assessing biologics for AD, complicating the comparison of their sustained responses in the absence of head-to…
View article: Real-World Use of Tapinarof Cream 1% Once Daily in Patients with Seborrheic Dermatitis: A Case Series.
Real-World Use of Tapinarof Cream 1% Once Daily in Patients with Seborrheic Dermatitis: A Case Series. Open
Seborrheic dermatitis (SD) is an inflammatory skin disease with multifactorial etiology, involving genetic and environmental factors. Many conventional therapies for SD (ie, topical antifungals, topical corticosteroids) are associated with…
View article: Use of Midodrine for Intraoperative Hemostasis in Cutaneous and Percutaneous Surgery
Use of Midodrine for Intraoperative Hemostasis in Cutaneous and Percutaneous Surgery Open
View article: Long-Term Maintenance of Optimal Treatment Targets for Skin and Itch Outcomes With Upadacitinib in Moderate-to-Severe Atopic Dermatitis: 140-Week Results From the Phase 3 Measure Up 1 and 2 Studies
Long-Term Maintenance of Optimal Treatment Targets for Skin and Itch Outcomes With Upadacitinib in Moderate-to-Severe Atopic Dermatitis: 140-Week Results From the Phase 3 Measure Up 1 and 2 Studies Open
Introduction: Despite undergoing prolonged systemic therapy, many patients with moderate-to-severe atopic dermatitis (AD) do not achieve optimal targets for skin and itch outcomes as defined by Aiming High in Eczema/AD (AHEAD) recommendati…
View article: Deucravacitinib in Plaque Psoriasis: Maintenance of Response Over 4 Years in the Phase 3 POETYK PSO-1, PSO-2, and LTE Trials
Deucravacitinib in Plaque Psoriasis: Maintenance of Response Over 4 Years in the Phase 3 POETYK PSO-1, PSO-2, and LTE Trials Open
Introduction: Deucravacitinib, an oral, selective, allosteric TYK2 inhibitor, was superior to placebo and apremilast in two global, phase 3 trials (POETYK PSO-1 and PSO-2) in moderate to severe plaque psoriasis. At Week 52, patients could …
View article: Hypertrophic Lichen Planus Due to Koebnerization After Percutaneous Vascular Procedure
Hypertrophic Lichen Planus Due to Koebnerization After Percutaneous Vascular Procedure Open
View article: Antiseptic and Antibiotic Stewardship in Dermatologic Surgery: Is Benzoyl Peroxide the Solution?
Antiseptic and Antibiotic Stewardship in Dermatologic Surgery: Is Benzoyl Peroxide the Solution? Open
Benzoyl peroxide may be a used as an antiseptic in dermatologic surgery of sebaceous areas to prevent post-operative infections, with a low likelihood of causing microbial resistance.
View article: INDIVIDUAL ARTICLE: Update on Combined Topical Products for Treating Acne: Leaping From Dyads
INDIVIDUAL ARTICLE: Update on Combined Topical Products for Treating Acne: Leaping From Dyads Open
Antibiotic resistance and treatment adherence remain significant challenges for acne treatment. Advances in topical formulations have ushered in an era of fixed combination topical therapeutics that are well-tolerated and more efficacious.…
View article: Treatment of oral lichen planus using deucravacitinib
Treatment of oral lichen planus using deucravacitinib Open
View article: Report of novel treatment of segmental vitiligo using combined microneedling and topical ruxolitinib
Report of novel treatment of segmental vitiligo using combined microneedling and topical ruxolitinib Open
Vitiligo is a chronic disease which manifests as patchy loss of skin pigmentation. It can be classified into two main types: segmental and nonsegmental. The condition can result in significant negative psychosocial effects, especially in s…
View article: FULL SUPPLEMENT: Brodalumab: Five Years of Real-World Safety and Efficiency
FULL SUPPLEMENT: Brodalumab: Five Years of Real-World Safety and Efficiency Open
Psoriasis remains a highly prevalent condition in the United States and worldwide. Preclinical research has been triumphant in elucidating the critical immunological pathways involved in psoriasis. There has been an evolution in biologics …
View article: Beard Alopecia: An Updated and Comprehensive Review of Etiologies, Presentation and Treatment
Beard Alopecia: An Updated and Comprehensive Review of Etiologies, Presentation and Treatment Open
Facial hair is an important social and psychologic aspect of clinical appearance for men. The purpose of this review is to provide a comprehensive overview of the causes of alopecia of the beard including the prevalence, pathophysiology, c…
View article: Platelet rich plasma combination therapies for treatment of androgenetic alopecia: A systematic review
Platelet rich plasma combination therapies for treatment of androgenetic alopecia: A systematic review Open
Androgenetic alopecia (AGA) is the most common cause of alopecia in males and females. Minoxidil and finasteride are the only FDA-approved treatments for AGA. New treatments including Platelet Rich Plasma (PRP) and microneedling have shown…
View article: First Use of Tapinarof Monotherapy for Seborrhoeic Dermatitis: A Case Report
First Use of Tapinarof Monotherapy for Seborrhoeic Dermatitis: A Case Report Open
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View article: Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs
Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs Open
Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women. Traditionally, topical minoxidil and oral finasteride have been the standard of care yielding mixed results. New treatments such as Low-Level Laser Therapy…
View article: Low-Level Light Therapy and Minoxidil Combination Treatment in Androgenetic Alopecia: A Review of the Literature
Low-Level Light Therapy and Minoxidil Combination Treatment in Androgenetic Alopecia: A Review of the Literature Open
Introduction: We analyzed randomized clinical trials (RCTs) evaluating the efficacy of combined therapy with low-level light therapy (LLLT) and topical minoxidil for treatment of androgenetic alopecia (AGA). Methods: A literature search wi…
View article: ES-Screen: A Novel Electrostatics-Driven Method for Drug Discovery Virtual Screening
ES-Screen: A Novel Electrostatics-Driven Method for Drug Discovery Virtual Screening Open
Electrostatic interactions drive biomolecular interactions and associations. Computational modeling of electrostatics in biomolecular systems, such as protein-ligand, protein–protein, and protein-DNA, has provided atomistic insights into t…
View article: A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer
A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer Open
Environmental chemical (EC) exposures and our interactions with them has significantly increased in the recent decades. Toxicity associated biological characterization of these chemicals is challenging and inefficient, even with available …
View article: JAAD Case Reports Article List
JAAD Case Reports Article List Open
View article: Trichoscopy for the Hair Transplant Surgeon—Assessing for Mimickers of Androgenetic Alopecia and Preoperative Evaluation of Donor Site Area
Trichoscopy for the Hair Transplant Surgeon—Assessing for Mimickers of Androgenetic Alopecia and Preoperative Evaluation of Donor Site Area Open
Preoperative diagnostic confidence and donor site assessment are important for all hair transplant surgery patients. While the majority of patients seek hair transplantation for male or female pattern hair loss (androgenetic alopecia [AGA]…