Nasser Hadal Alotaibi
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View article: Correction: Bukhari et al. Covalent Organic Frameworks (COFs) as Multi-Target Multifunctional Frameworks. Polymers 2023, 15, 267
Correction: Bukhari et al. Covalent Organic Frameworks (COFs) as Multi-Target Multifunctional Frameworks. Polymers 2023, 15, 267 Open
In the original publication [...]
View article: From Flower to Medicine: Green-Synthesized Silver Nanoparticles as Promising Antibacterial Agents
From Flower to Medicine: Green-Synthesized Silver Nanoparticles as Promising Antibacterial Agents Open
Background: Breast cancer and chronic bacterial infections are pressing global health issues, and traditional treatments are often hampered by resistance and adverse side effects. This study sought to create silver nanoparticles (AgNPs) th…
View article: Appraisal of healthcare students and professionals’ knowledge and intention to educate the public regarding monkeypox (Mpox)
Appraisal of healthcare students and professionals’ knowledge and intention to educate the public regarding monkeypox (Mpox) Open
Background In light of the increasing prevalence of monkeypox (Mpox) infections worldwide, it is critical to assess the level of awareness regarding the disease and its transmission among healthcare students and professionals. Understandin…
View article: Preventing and management of mouth ulcers caused by orthodontic
Preventing and management of mouth ulcers caused by orthodontic Open
Orthodontic-induced mouth ulcers are a common complication arising from mechanical irritation and increased plaque accumulation during treatment. These painful lesions significantly impact the comfort and compliance of patients undergoing …
View article: Addressing Medical Trauma in Nursing Practice: A Trauma-Informed Care Approach: A Review Study
Addressing Medical Trauma in Nursing Practice: A Trauma-Informed Care Approach: A Review Study Open
Background: Medical trauma, a psychophysiological response to distressing healthcare experiences, stands as a common yet usually neglected health problem. Seriously ill patients, cancer patients, or patients who need an invasive procedure …
View article: Adult Simultaneous Cochlear Implantation: Local Anesthesia
Adult Simultaneous Cochlear Implantation: Local Anesthesia Open
Purpose: Cochlear implant (CI) surgery is conventionally done under general anesthesia (GA). However, many patients are unable to undergo GA due to various reasons, raising the need for an alternative safe option. CI under local anesthesia…
View article: High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract
High Antiparasitic and Antimicrobial Performance of Biosynthesized NiO Nanoparticles via Wasted Olive Leaf Extract Open
Nanoparticles of NiO-olive outperformed nanoparticles of NiO-pure and olive leaf extract in both antiparasitic and antimicrobial tests. These findings imply that NiO-olive may be widely used as an eco-friendly and effective antiparasitic a…
View article: Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies Open
NSAIDs represent a mainstay in pain and inflammation suppression, and their actions are mainly based on inhibiting COX-1 and COX-2 enzymes. Due to the adverse effects of these drugs, especially on the stomach and heart, scientists efforts …
View article: Evaluation of Utilization and Satisfaction of Patients towards Pharmaceutical Services in Hospitals: A Descriptive Study from Al-Jouf Region of Saudi Arabia
Evaluation of Utilization and Satisfaction of Patients towards Pharmaceutical Services in Hospitals: A Descriptive Study from Al-Jouf Region of Saudi Arabia Open
Background: It is essential to measure pharmaceutical services in order to identify areas of weakness and implement corrective measures. This study aimed to measure the utilization of pharmaceutical services in hospitals in Al-Jouf region …
View article: Local and Systemic side effects of COVID-19 Vaccines
Local and Systemic side effects of COVID-19 Vaccines Open
Background: To increase the public's acceptance of the vaccine, knowledge of its side effects is crucial. Thus, the purpose of this study was to identify side effects in the Saudi population following vaccinations with Pfizer BioNTech and …
View article: Erythropoietin Protective Role Against Methotrexate Testicular Adverse Effects
Erythropoietin Protective Role Against Methotrexate Testicular Adverse Effects Open
Background: The adverse effects of cytotoxic medications like methotrexate, particularly reproductive damage reported in the numerous experimental studies, limit their effectiveness as anticancer therapies. The current study's objectives w…
View article: Synthesis and performance of ultrafiltration membranes incorporated with different oxide nanomaterials: experiments and modeling
Synthesis and performance of ultrafiltration membranes incorporated with different oxide nanomaterials: experiments and modeling Open
In membrane filtration technology, membrane fouling is the primary obstacle to optimizing efficiency and results in a short membrane lifetime and high operating costs. By incorporating nanomaterials into the membrane synthesis process, a m…
View article: Evaluation of Outreach of Community Pharmacists in Public Health Services in Al-Jouf Region of Saudi Arabia: Findings and Implications
Evaluation of Outreach of Community Pharmacists in Public Health Services in Al-Jouf Region of Saudi Arabia: Findings and Implications Open
Background: Diversifying the conventional role of community pharmacists from dispensing to involvement in public health services could help in optimized patient care and ultimately good health practices. The current study aimed to ascertai…
View article: Biochemical association of regulatory variant of KLF14 genotype in the pathogenesis of cardiodiabetic patients
Biochemical association of regulatory variant of KLF14 genotype in the pathogenesis of cardiodiabetic patients Open
Background and purpose The study focuses on examining the relationship between a single nucleotide polymorphism (SNP) in KLF14 rs4731702 and risk of type 2 diabetes mellitus (T2DM) and dyslipidemia in different ethnic populations. The purp…
View article: Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment [Retraction]
Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment [Retraction] Open
[This retracts the article DOI: 10.2147/IJN.S254763.].
View article: Synthesis, Characterization, and Biological Evaluation of Meldrum’s Acid Derivatives: Dual Activity and Molecular Docking Study
Synthesis, Characterization, and Biological Evaluation of Meldrum’s Acid Derivatives: Dual Activity and Molecular Docking Study Open
In the presented study, eight novel Meldrum’s acid derivatives containing various vanillic groups were synthesized. Vanillidene Meldrum’s acid compounds were tested against different cancer cell lines and microbes. Out of nine, three showe…
View article: Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor
Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor Open
Myocardial infarction (MI) is a cardiovascular disease that occurs due to the blockage of the coronary artery. Subsequently, cardiac muscles receive a lower oxygen supply, which leads to the death of cardiac muscles. The etiology of MI is …
View article: The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, <i>in vitro</i> , and <i>in silico</i> mechanistic investigations
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, <i>in vitro</i> , and <i>in silico</i> mechanistic investigations Open
Treatment options for the management of breast cancer are still inadequate. This inadequacy is attributed to the lack of effective targeted medications, often resulting in the recurrence of metastatic disorders. Cumulative evidence suggest…
View article: Integrating laboratory findings into pharmacological pain management and nursing care plans
Integrating laboratory findings into pharmacological pain management and nursing care plans Open
Background: Effective pain management remains a cornerstone of modern healthcare, encompassing both pharmacological interventions and nursing care strategies. Advances in laboratory diagnostics have revolutionized personalized medicine, of…
View article: Covalent Organic Frameworks (COFs) as Multi-Target Multifunctional Frameworks
Covalent Organic Frameworks (COFs) as Multi-Target Multifunctional Frameworks Open
Covalent organic frameworks (COFs), synthesized from organic monomers, are porous crystalline polymers. Monomers get attached through strong covalent bonds to form 2D and 3D structures. The adjustable pore size, high stability (chemical an…
View article: Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction
Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction Open
The arylidene indolin-2-ones showed significant dual biological activity against MCF-T cancer cell lines and Candida species. The most promising molecule for further investigation contains an m -aminophenyl fragment.
View article: Surveillance of Side Effects after Two Doses of COVID-19 Vaccines among Patients with Comorbid Conditions: A Sub-Cohort Analysis from Saudi Arabia
Surveillance of Side Effects after Two Doses of COVID-19 Vaccines among Patients with Comorbid Conditions: A Sub-Cohort Analysis from Saudi Arabia Open
Background: Individuals with underlying chronic illnesses have demonstrated considerable hesitancy towards COVID-19 vaccines. These concerns are primarily attributed to their concerns over the safety profile. Real-world data on the safety …
View article: Effect of Pirfenidone on Risk of Pulmonary Fibrosis in COVID-19 Patients Experiencing Cytokine Storm
Effect of Pirfenidone on Risk of Pulmonary Fibrosis in COVID-19 Patients Experiencing Cytokine Storm Open
Objectives: Severe stages of COVID-19 infection have been associated with the excessive discharge of pro-inflammatory mediators such as cytokines, resulting in lung deterioration, which progresses rapidly to lung fibrosis leading to acute …
View article: Barriers and facilitators of childhood COVID-19 vaccination among parents: A systematic review
Barriers and facilitators of childhood COVID-19 vaccination among parents: A systematic review Open
Background The acceptance of vaccination against COVID-19 among parents of young children plays a significant role in controlling the current pandemic. A wide range of factors that influence vaccine hesitancy in adults has been reported wo…
View article: Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews
Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews Open
The COVID-19 associated acute kidney injury (CAKI) has emerged as a potential intricacy during the management of patients. Navigating the rapidly growing body of scientific literature on CAKI is challenging, and ongoing critical appraisal …
View article: Evaluation of Conspiracy Beliefs, Vaccine Hesitancy, and Willingness to Pay towards COVID-19 Vaccines in Six Countries from Asian and African Regions: A Large Multinational Analysis
Evaluation of Conspiracy Beliefs, Vaccine Hesitancy, and Willingness to Pay towards COVID-19 Vaccines in Six Countries from Asian and African Regions: A Large Multinational Analysis Open
Vaccination protects people from serious illness and associated complications. Conspiracy theories and misinformation on vaccines have been rampant during the COVID-19 pandemic and are considered significant drivers of vaccine hesitancy. S…
View article: Estimation of Psychological Impairment and Coping Strategies during COVID-19 Pandemic among University Students in Saudi Arabia: A Large Regional Analysis
Estimation of Psychological Impairment and Coping Strategies during COVID-19 Pandemic among University Students in Saudi Arabia: A Large Regional Analysis Open
Background: The COVID-19 pandemic and associated restrictive measures have substantially affected educational processes around the globe, resulting in psychological distress among students. The mental health of students in higher education…
View article: Evaluation of knowledge and barriers of influenza vaccine uptake among university students in Saudi Arabia; a cross-sectional analysis
Evaluation of knowledge and barriers of influenza vaccine uptake among university students in Saudi Arabia; a cross-sectional analysis Open
Background Influenza vaccine hesitancy is a significant threat to global maneuvers for reducing the burden of seasonal and pandemic influenza. This study estimated the vaccine uptake, barriers, and willingness for influenza vaccines among …
View article: Evaluation of Impact of a Pharmacist-Led Educational Campaign on Disease Knowledge, Practices and Medication Adherence for Type-2 Diabetic Patients: A Prospective Pre- and Post-Analysis
Evaluation of Impact of a Pharmacist-Led Educational Campaign on Disease Knowledge, Practices and Medication Adherence for Type-2 Diabetic Patients: A Prospective Pre- and Post-Analysis Open
Type 2 Diabetes mellitus is a major public health concern with an alarming global growth rate. According to the World Health Organization (WHO), Saudi Arabia ranks seventh in the world and second in the Middle East for the largest estimate…
View article: Relationship between the use of drugs and changes in body weight among patients: A systematic review and meta-analysis
Relationship between the use of drugs and changes in body weight among patients: A systematic review and meta-analysis Open
Purpose: To investigate the impact of drugs on the body weight of patients.Methods: All the randomized controlled trials that evaluated the impact of medications on the body weight of patients were searched in various databases. Studies qu…