Naili Liu
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View article: Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism
Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism Open
Growth hormone (GH) signaling through STAT5B is a central regulator of hepatic metabolism, yet the functional consequences of disease-associated STAT5B variants remain poorly understood. Here, we analyzed mice carrying STAT5B Y665F (gain-o…
View article: P2Y<sub>14</sub> Receptor Antagonists: Piperidine Bioisosteres and Mutagenesis-Supported Molecular Modeling
P2Y<sub>14</sub> Receptor Antagonists: Piperidine Bioisosteres and Mutagenesis-Supported Molecular Modeling Open
The human P2Y14 receptor (hP2Y14R) has emerged as a promising target for inflammation and pain treatment, but its zwitterionic antagonists have low bioavailability. We extended the naphthalene-based antagonist series' structure-activity re…
View article: Virtual Machine Placement in Edge Computing Based on Multi-Objective Reinforcement Learning
Virtual Machine Placement in Edge Computing Based on Multi-Objective Reinforcement Learning Open
With the popularization of internet of things (IoT), the energy consumption of mobile edge computing (MEC) servers is also on the rise. Some important IoT applications, such as autonomous driving, smart manufacturing, and smart wearables, …
View article: Beyond day and night: The importance of ultradian rhythms in mouse physiology
Beyond day and night: The importance of ultradian rhythms in mouse physiology Open
Our circadian world shapes much of metabolic physiology. In mice ∼40% of the light and ∼80% of the dark phase time is characterized by bouts of increased energy expenditure (EE). These ultradian bouts have a higher body temperature (Tb) an…
View article: A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice
A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice Open
Melanocortin 4 receptor (MC4R) mutations are the most common cause of human monogenic obesity and are associated with hyperphagia and increased linear growth. While MC4R is known to activate Gsα/cAMP signaling, a substantial proportion of …
View article: 2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A<sub>1</sub> Adenosine Receptor Positive Allosteric Modulators
2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A<sub>1</sub> Adenosine Receptor Positive Allosteric Modulators Open
A1 adenosine receptor (A1AR) agonists have cerebroprotective, cardioprotective, antinociceptive, and other pharmaceutical applications. We explored the structure-activity relationship of 5-arylethynyl aminothiophenes as A1AR positive allos…
View article: Loss of Otopetrin 1 affects thermoregulation during fasting in mice
Loss of Otopetrin 1 affects thermoregulation during fasting in mice Open
Objective Otopetrin 1 (OTOP1) is a proton channel that is highly expressed in brown adipose tissue. We examined the physiology of Otop1 -/- mice, which lack functional OTOP1. Methods Mice were studied by indirect calorimetry and telemetric…
View article: Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP
Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP Open
Neuropeptides may exert trophic effects during development, and then neurotransmitter roles in the developed nervous system. One way to associate peptide‐deficiency phenotypes with either role is first to assess potential phenotypes in so‐…
View article: Purinergic Signaling In Vivo Phenotypic Validation of Adenosine Receptor-Dependent Activity of Non-adenosine Drugs
Purinergic Signaling In Vivo Phenotypic Validation of Adenosine Receptor-Dependent Activity of Non-adenosine Drugs Open
Some non-adenosinergic drugs are reported to also act through adenosine receptors (ARs). We used mouse hypothermia, which can be induced by agonism at any of the four ARs, as an in vivo screen for adenosinergic effects. An AR contribution …
View article: Combining a β3 adrenergic receptor agonist with alpha‐lipoic acid reduces inflammation in male mice with diet‐induced obesity
Combining a β3 adrenergic receptor agonist with alpha‐lipoic acid reduces inflammation in male mice with diet‐induced obesity Open
Objectives Beta‐3 adrenergic receptors (β3‐AR) stimulate lipolysis and thermogenesis in white and brown adipose tissue (WAT and BAT). Obesity increases oxidative stress and inflammation that attenuate AT β3‐AR signaling. The objective of t…
View article: The contribution of the mouse tail to thermoregulation is modest
The contribution of the mouse tail to thermoregulation is modest Open
Understanding mouse thermal physiology informs the usefulness of mice as models of human disease. It is widely assumed that the mouse tail contributes greatly to heat loss (as it does in rat), but this has not been quantitated. We studied …
View article: Mouse Thermoregulation: Introducing the Concept of the Thermoneutral Point
Mouse Thermoregulation: Introducing the Concept of the Thermoneutral Point Open
Human and mouse thermal physiology differ due to dissimilar body sizes. Unexpectedly, in mice we found no ambient temperature zone where both metabolic rate and body temperature were constant. Body temperature began increasing once cold-in…
View article: CaMKII oxidation is a performance/disease trade-off in vertebrate evolution
CaMKII oxidation is a performance/disease trade-off in vertebrate evolution Open
Reactive oxygen species (ROS) contribute to health and disease. CaMKII is a widely expressed enzyme whose activation by oxidation of regulatory domain methionines (ox-CaMKII) contributes to cardiovascular disease, asthma, and cancer. Here …
View article: Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures
Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures Open
Background Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a less severe phen…
View article: Research and Application of Big Data in E-government
Research and Application of Big Data in E-government Open
The wide use of modern electronic information technology, represented by big data technology, has brought people into the era of big data. Big data is affecting our work, life, even economy and the development of the society. Nowadays, the…
View article: SAT-038 Physiology of Mice Lacking All Four Adenosine Receptors
SAT-038 Physiology of Mice Lacking All Four Adenosine Receptors Open
The importance of multiple adenosine receptors (AR) and the role of adenosine signaling in normal physiology, as opposed to danger/damage situations, are unclear. We generated mice (QKO) lacking all four AR, Adora1(-/-);Adora2a(-/-);Adora2…
View article: Physiology and effects of nucleosides in mice lacking all four adenosine receptors
Physiology and effects of nucleosides in mice lacking all four adenosine receptors Open
Adenosine is a constituent of many molecules of life; increased free extracellular adenosine indicates cell damage or metabolic stress. The importance of adenosine signaling in basal physiology, as opposed to adaptive responses to danger/d…
View article: Design and in Vivo Characterization of A<sub>1</sub> Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series
Design and in Vivo Characterization of A<sub>1</sub> Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series Open
(N)-Methanocarba ([3.1.0]bicyclohexyl) adenosines and corresponding ribosides were synthesized to identify novel A1 adenosine receptor (A1AR) agonists for CNS or peripheral applications. Human and mouse AR binding was determined to assess …
View article: Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors
Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors Open
Intraperitoneal administration of the melanocortin agonist melanotan II (MTII) to mice causes a profound, transient hypometabolism/hypothermia. It is preserved in mice lacking any one of melanocortin receptors 1, 3, 4, or 5, suggesting a m…