Explanipedia

Novel fat-taste enhancers modulate functional connectivity of the reward system following sustained activation of gustatory pathways in mice Open

Lidia Cabeza, Lucas Jantzen, C Houdayer, Émmanuel Haffen, Aziz Hichami , et al. · 2025

Humans and rodents exhibit an innate preference for dietary fat, and dysfunction of lingual fat-taste receptors CD36 and GPR120 in obesity suggests that impaired oro-sensory lipid detection may contribute to its development. Rodent models …

Sweet and Fat Taste Perception: Impact on Dietary Intake in Diabetic Pregnant Women—A Cross-Sectional Observational Study Open

Inchirah Karmous, Rym Ben Othman, Ismail Dergaa, Halil İ̇brahim Ceylan, C. Bey , et al. · 2025

Background: Taste changes are common during pregnancy and can have a significant impact on dietary habits. Objective: This study aimed to investigate the influence of the perception of sweet and fat taste on diet in pregnant diabetic women…

Natural bioactive compounds and their mechanisms of action in the management of obesity: a narrative review Open

Hassiba Benbaibeche, Ali Zineddine Boumehira, Naim Akhtar Khan · 2025

Obesity is a burning public health problem that affects both children and adult population all over the world. The incidence of obesity will increase in the coming years due to the urbanization of societies, which has led to unbalanced foo…

Celastrol Improves Preference for a Fatty Acid, and Taste Bud and Systemic Inflammation in Diet-Induced Obese Mice Open

M. Benmouna, Chahid Benammar, Amira Sayed Khan, Fatima Zohra Djeziri, Aziz Hichami , et al. · 2025

Background: Obesity is associated with the altered gustatory perception of dietary fatty acids. Celastrol, a triterpene, has been demonstrated to exert anti-obesity effects in rodents. We assessed the role of Celastrol in the modulation of…

Cardiometabolic Markers in Algerian Obese Subjects with and Without Type 2 Diabetes: Adipocytokine Imbalance as a Risk Factor Open

Hassiba Benbaibeche, Abdenour Bounihi, Hamza Saidi, Elhadj-Ahmed Koceir, Naim Akhtar Khan · 2025

Background/Objectives: An increase in body fat is linked to abnormalities in energy metabolism. We aimed at determining cardiometabolic risk in Algerian participants with obesity alone and with or without type 2 diabetes. The study measure…

Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments Open

Shuang Hao, Brian Güthrie, Soo-Kyung Kim, Sergej Balanda, Jan Kubíček , et al. · 2024

Distinct binding hotspots for natural and synthetic agonists of FFA4 from in silico approaches** Open

Guillaume Patient, Corentin Bedart, Naim Akhtar Khan, Nicolas Renault, Amaury Farce · 2024

FFA4 has gained interest in recent years since its deorphanization in 2005 and the characterization of the Free Fatty Acids receptors family for their therapeutic potential in metabolic disorders. The expression of FFA4 (also known as GPR1…

A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia Open

Pierre‐Marie Boutanquoi, Amira Sayed Khan, Lidia Cabeza, Lucas Jantzen, Thomas Gautier , et al. · 2024

Dietary linoleic acid supplementation protects against obesity-induced microglial reactivity in mice Open

Lucas Jantzen, Stéphanie Dumontoy, Bahrie Ramadan, C Houdayer, Émmanuel Haffen , et al. · 2024

We investigated whether linoleic acid (LA) supplementation could modulate emotional behavior and microglia-related neuroinflammation. For that, male mice of C57BL/6J genetic background fed either a high-fat diet (HFD) or a standard diet (S…

Immunomodulatory and antitumoral potentials of polyphenol-rich Salsola tetrandra leaf extract Open

Sarra Dakhlaoui, Emna Chaabani, Abdelhafidh Nani, Wided Ksouri-Megdiche, Riadh Ksouri , et al. · 2024

This study explored the influence of Salsola tetrandra leaf polyphenol-rich extract (STLPRE) on RAW 264.7 macrophage polarization and its potential antitumoral effects on transplanted mouse melanoma cells (B16). The phenolic contents and a…

Steviol Rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments Open

Shuang Hao, Brian Güthrie, Soo-Kyung Kim, Sergej Balanda, Jan Kubíček , et al. · 2024

Sucrose provide sweetness and energy when it binds to both the Venus fly trap domains (VFD) of heterodimeric sweet taste receptor (T1R2/T1R3),1 while non-caloric sweeteners (Sucralose, Aspartame, Neotame, Saccharin, Acesulfame-K (Ace-K), S…

Linoleic acid supplementation reverses microglial response to diet induced-obesity at hypothalamic, cortical and subcortical level in mice Open

Lucas Jantzen, Stéphanie Dumontoy, Bahrie Ramadan, C Houdayer, Émmanuel Haffen , et al. · 2023

Obesity is a major risk factor for neuropsychiatric alterations. Fatty regimes lead to systemic and cerebral inflammation, the latest acting through lipotoxicity on hypothalamic structures controlling energy homeostasis. Since literature p…

In Vitro Functional Characterization of Type-I Taste Bud Cells as Monocytes/Macrophages-like Which Secrete Proinflammatory Cytokines Open

Aziz Hichami, Hamza Saidi, Amira Sayed Khan, Pernelle Degbeni, Naim Akhtar Khan · 2023

The sense of taste determines the choice of nutrients and food intake and, consequently, influences feeding behaviors. The taste papillae are primarily composed of three types of taste bud cells (TBC), i.e., type I, type II, and type III. …

Loss of Sour Taste Is the Striking Feature among Four Basic Taste Qualities in Tunisian COVID-19 Patients Open

Inchirah Karmous, Amira Sayed Khan, I. Sahnoun, Rym Ben Othman, Houda Ben Jemaa , et al. · 2023

Background: Taste disorders (TDs) have been reported to be very common in patients suffering from coronavirus disease 2019 (COVID-19), which is caused by the SARS-CoV-2 virus. In most of the hitherto conducted studies, a gustatory assessme…

New Insights Into the Anticancer Effects of <i>p</i>-Coumaric Acid: Focus on Colorectal Cancer Open

Wafâa Tehami, Abdelhafid Nani, Naim Akhtar Khan, Aziz Hichami · 2023

Colorectal cancer is considered the second most deadly cancer in the world. Studies have indicated that diet can prevent the risk of developing colorectal cancer. Recently, there has been an increasing interest in polyphenols due to their …

Novel Fat Taste Receptor Agonists Curtail Progressive Weight Gain in Obese Male Mice Open

Amira Sayed Khan, Aziz Hichami, Babar Murtaza, Marie‐Laure Louillat‐Habermeyer, Christophe Ramseyer , et al. · 2022

Association between polymorphisms and hypermethylation of CD36 gene in obese and obese diabetic Senegalese females Open

Maïmouna Touré, Aziz Hichami, Amira Sayed, Muhtadi Suliman, Abdoulaye Samb , et al. · 2022

Background Obesity and related metabolic disorders are associated with genetic and epigenetic alterations. In this study, we have examined the association between polymorphisms and hypermethylation of the CD36 gene promoter with obesity in…

Editorial: Free Fatty Acids as Signaling Molecules: Role of Free Fatty Acid Receptors and CD36 Open

Carlos Puebla, Eugenia Morselli, Naim Akhtar Khan, Mauricio A. Retamal · 2022

EDITORIAL article Front. Physiol., 16 March 2022Sec. Membrane Physiology and Membrane Biophysics https://doi.org/10.3389/fphys.2022.862458

Taste of Fat and Obesity: Different Hypotheses and Our Point of View Open

Laurent Brondel, Didier Quilliot, Thomas Mouillot, Naim Akhtar Khan, Philip Bastable , et al. · 2022

Obesity results from a temporary or prolonged positive energy balance due to an alteration in the homeostatic feedback of energy balance. Food, with its discriminative and hedonic qualities, is a key element of reward-based energy intake. …

Tongue Leptin Decreases Oro-Sensory Perception of Dietary Fatty Acids Open

Hameed Ullah, Amira Sayed Khan, Babar Murtaza, Aziz Hichami, Naim Akhtar Khan · 2021

Leptin, an anorectic hormone, regulates food intake, energy expenditure and body weight. We assessed the implication of tongue leptin in the modulation of oro-sensory detection of dietary fatty acids in mice. The RT-PCR analysis showed tha…

Incidence of Measles in Breastfed Infants versus Non-Breastfed Infants Open

Naim Akhtar Khan, Zabit Khan, Naim Khan Zadran · 2021

Breast-feeding protects newborn infants against numerous infectious conditions and sicknesses, and can also affect the results of vaccination. The main purpose of this research is to assess breastfeeding defends against CM and find the cha…

Un nouvel acteur dans la perception gustative des lipides alimentaires : le canal calcique TRPC3 Open

Amira Sayed Khan, Aziz Hichami, Naim Akhtar Khan · 2021

International audience

Management of Childhood Obesity—Time to Shift from Generalized to Personalized Intervention Strategies Open

Mohamad Motevalli, Clemens Drenowatz, Derrick Tanous, Naim Akhtar Khan, Katharina Wirnitzer · 2021

As a major public health concern, childhood obesity is a multifaceted and multilevel metabolic disorder influenced by genetic and behavioral aspects. While genetic risk factors contribute to and interact with the onset and development of e…

Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms Open

Abdelhafid Nani, Babar Murtaza, Amira Sayed Khan, Naim Akhtar Khan, Aziz Hichami · 2021

Nutrition transition can be defined as shifts in food habits, and it is characterized by high-fat (chiefly saturated animal fat), hypercaloric and salty food consumption at the expense of dietary fibers, minerals and vitamins. Western diet…

Study of epidemiological, clinical and evolutionary characteristics of a population of patients hospitalized for COVID-19 in Morocco Open

Jaâfar Heikel, Hasnae Benkirane, Fadoua Ballouk, Amina Bouziani, Fatima Zahra Laamırı , et al. · 2021

The outbreak of COVID-19 still represents a real risk for the increased death rate for the whole of human kind. In this context, the present research work aims at describing evolutionary data in a population of hospitalized COVID-19 positi…

Nutritional properties and plausible benefits of Pearl millet (Pennisetum glaucum) on bone metabolism and osteoimmunology : a mini-review Open

Abdelhafid Nani, Meriem Belarbi, Naim Akhtar Khan, Aziz Hichami · 2020

Bone is a hard connective tissue that undergoes a systematic renewal. This highly dynamic organ is made up of four different types of cells, however, bone formation is commonly attributed to osteoblasts and bone resorption to osteoclasts. …