Explanipedia

Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing Open

Omar H. Maarouf, Mayuko Uehara, Vivek Kasinath, Zhabiz Solhjou, Naima Banouni , et al. · 2025

Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells Open

Deepak Bhere, Sung Hugh Choi, Pim van de Donk, David Hope, Kiki Gortzak , et al. · 2025

Characterization of CD41+ cells in the lymph node Open

Li Dai, Mayuko Uehara, Xiaofei Li, Brenna A. LaBarre, Naima Banouni , et al. · 2022

Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stro…

RETRACTED ARTICLE: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells Open

Deepak Bhere, Sung Hugh Choi, Pim van de Donk, David Hope, Kiki Gortzak , et al. · 2022

Cellular therapies offer a promising therapeutic strategy for the highly malignant brain tumor, glioblastoma (GBM). However, their clinical translation is limited by the lack of effective target identification and stringent testing in pre-…

Characterization of Leptin Receptor+ Stromal Cells in Lymph Node Open

Liwei Jiang, Mine Yilmaz, Mayuko Uehara, Cecília B. Cavazzoni, Vivek Kasinath , et al. · 2022

Lymph node (LN)-resident stromal cells play an essential role in the proper functioning of LNs. The stromal compartment of the LN undergoes significant compensatory changes to produce a milieu amenable for regulation of the immune response…

ACTH treatment promotes murine cardiac allograft acceptance Open

Jing Zhao, Liwei Jiang, Mayuko Uehara, Naima Banouni, Basmah S. Al Dulaijan , et al. · 2021

Heart transplantation is the optimal therapy for patients with end-stage heart disease, but its long-term outcome remains inadequate. Recent studies have highlighted the importance of the melanocortin receptors (MCRs) in inflammation, but …

Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy Open

Liwei Jiang, Yi‐Jun Wang, Jing Zhao, Mayuko Uehara, Qingming Hou , et al. · 2020

Cellular Mechanisms of Rejection of Optic and Sciatic Nerve Transplants: An Observational Study Open

Merve Yonar, Mayuko Uehara, Naima Banouni, Vivek Kasinath, Xiaofei Li , et al. · 2020

Background. Organ transplantation is a standard therapeutic strategy for irreversible organ damage, but the utility of nerve transplantation remains generally unexplored, despite its potential benefit to a large patient population. Here, w…

Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation Open

Xiaofei Li, Jing Zhao, Vivek Kasinath, Mayuko Uehara, Liwei Jiang , et al. · 2020

Although the immune response within draining lymph nodes (DLNs) has been studied for decades, how their stromal compartment contributes to this process remains to be fully explored. Here, we show that donor mast cells were prominent activa…

Nanodelivery of Mycophenolate Mofetil to the Organ Improves Transplant Vasculopathy Open

Mayuko Uehara, Baharak Bahmani, Liwei Jiang, Sungwook Jung, Naima Banouni , et al. · 2019

Inflammation occurring within the transplanted organ from the time of harvest is an important stimulus of early alloimmune reactivity and promotes chronic allograft rejection. Chronic immune-mediated injury remains the primary obstacle to …

Immune heterogeneity of head and tail pancreatic lymph nodes in non-obese diabetic mice Open

Xiaofei Li, Asher Bean, Mayuko Uehara, Naima Banouni, Moufida Ben Nasr , et al. · 2019

The pancreatic lymph node is critical to the pathogenesis of autoimmune diabetes, as it constitutes the initial site for the priming of autoreactive T cells. In this study, we compared the histopathology of the head pancreatic lymph node (…

Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival Open

Mayuko Uehara, Xiaofei Li, Amir Sheikhi, Nooshin Zandi, Brian W. Walker , et al. · 2019

A primary goal in the management of burn wounds is early wound closure. The use of skin allografts represents a lifesaving strategy for severe burn patients, but their ultimate rejection limits their potential efficacy and utility. IL-6 is…

Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery Open

Baharak Bahmani, Mayuko Uehara, Farideh Ordikhani, Xiaofei Li, Liwei Jiang , et al. · 2018

Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival Open

Baharak Bahmani, Mayuko Uehara, Liwei Jiang, Farideh Ordikhani, Naima Banouni , et al. · 2018

The targeted delivery of therapeutic drugs to lymph nodes (LNs) provides an unprecedented opportunity to improve the outcomes of transplantation and immune-mediated diseases. The high endothelial venule is a specialized segment of LN vascu…

Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing Open

Omar H. Maarouf, Mayuko Uehara, Vivek Kasinath, Zhabiz Solhjou, Naima Banouni , et al. · 2018

The contribution of the kidney-draining lymph node (KLN) to the pathogenesis of ischemia-reperfusion injury (IRI) of the kidney and its subsequent recovery has not been explored in depth. In addition, the mechanism by which repetitive IRI …

Ischemia augments alloimmune injury through IL-6-driven CD4+ alloreactivity Open

Mayuko Uehara, Zhabiz Solhjou, Naima Banouni, Vivek Kasinath, Ye Xiaqun , et al. · 2018

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ Open

Mayuko Uehara, Martina M. McGrath, Shunsuke Ohori, Zhabiz Solhjou, Naima Banouni , et al. · 2017

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