Naining Wang
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View article: The function of GPCRs in different bone cells
The function of GPCRs in different bone cells Open
G protein-coupled receptors (GPCRs) are recognized as critical therapeutic targets in bone disorders, owing to their multifaceted regulatory roles across diverse bone cell lineages. This review systematically catalogs GPCR expression and f…
View article: RUNX2 Phase Separation Mediates Long‐Range Regulation Between Osteoporosis‐Susceptibility Variant and <i>XCR1</i> to Promote Osteoblast Differentiation
RUNX2 Phase Separation Mediates Long‐Range Regulation Between Osteoporosis‐Susceptibility Variant and <i>XCR1</i> to Promote Osteoblast Differentiation Open
GWASs have identified many loci associated with osteoporosis, but the underlying genetic regulatory mechanisms and the potential drug target need to be explored. Here, a new regulatory mechanism is found that a GWAS intergenic SNP (rs46831…
View article: Steroid lifting method during endoscopic submucosal dissection: A novel strategy for stricture prevention
Steroid lifting method during endoscopic submucosal dissection: A novel strategy for stricture prevention Open
A 73‐year‐old male patient was referred to us with a long Barrett's esophagus (BE). He had a history of pulmonary embolism under anticoagulant therapy. Esophagogastroduodenoscopy showed a C8M9 BE with no macroscopic lesions. Random biopsie…
View article: Complete resection of a circumferential distal duodenum lesion by endoscopic submucosal dissection
Complete resection of a circumferential distal duodenum lesion by endoscopic submucosal dissection Open
A 71-year-old woman with a lesion extending around the entire luminal circumference along a 10-cm length of the distal duodenum was referred to us at Karolinska University Hospital. Esophagogastroduodenoscopy (EGD) revealed an irregular, h…
View article: Traction-assisted endoscopic submucosal dissection of a duodenal gastrointestinal stromal tumor
Traction-assisted endoscopic submucosal dissection of a duodenal gastrointestinal stromal tumor Open
A 70-year-old woman with a gastric adenocarcinoma and a subepithelial lesion in the distal descending duodenum ([Fig. 1]) was referred to us. On endoscopic ultrasound (EUS), a 15-mm hypoechoic, regular, and homogeneous lesion engaging the …
View article: Wide-field endoscopic submucosal dissection for the treatment of Barrett’s esophagus neoplasia
Wide-field endoscopic submucosal dissection for the treatment of Barrett’s esophagus neoplasia Open
Background and study aims Implementation of endoscopic submucosal dissection (ESD) for the treatment of Barrett’s esophagus neoplasia (BEN) has been hampered by high rates of positive margins and complications. Dissection with wider margin…
View article: Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption
Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption Open
Matrix Gla protein (MGP) is an extracellular protein responsible for inhibiting mineralization. MGP inhibits osteoblast mineralization and bone formation by regulating the deposition of bone matrix. However, Mgp-/- mice display an osteopen…
View article: An allele-specific functional SNP associated with two autoimmune diseases modulates<i>IRF5</i>expression by long-range chromatin loop formation
An allele-specific functional SNP associated with two autoimmune diseases modulates<i>IRF5</i>expression by long-range chromatin loop formation Open
Both Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc) are autoimmune diseases sharing similar genetic backgrounds. Genome-wide association studies (GWASs) have constantly disclosed numerous genetic variants conferring to bot…